ISSN:
1750-3841
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
The radiosensitizing activity of a series of naphthalene derivatives against Streptococcus faecalis and Escherichia coli was examined to determine the essential molecular substituents and configurations required for effective sensitization when the compounds and organisms were irradiated with Co60 gamma rays. In general, compounds with hydroxyl or amino groups in the ortho and para positions, such as 1-amino-2-naphthol and 4-amino-1-naphthol, were particularly effective sensitizers for S. faecalis irradiated in air or in anoxia. E. coli was particularly sensitive to 4-amino-1-naphthol and 5-amino-1-naphthol when irradiated in anoxia, and less sensitive in air. Both organisms displayed marked sensitivity when irradiated with iodoacetic acid in air and in anoxia. It was determined that the bacteria and chemicals must be irradiated together for maximal radiosensitization to take place, for it was possible to almost eliminate radiosensitization by washing the cell-chemical suspension prior to irradiation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2621.1964.tb01698.x
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