ISSN:
1432-1831
Schlagwort(e):
Interferon-β
;
Newcastle disease virus
;
Antiviral action
;
Selectivity to HN gene expression
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Interferon-β (IFN-β) strongly inhibited the expression of the hemagglutinin-neuraminidase (HN) gene of Newcastle disease virus (NDV), a paramyxovirus, in HeLa cells under the conditions where it did not affect the expression of the four upstream genes encoding the nucleocapsid protein, phosphoprotein, membrane protein and fusion protein. Even the downstream gene, encoding the large protein as well as the genome replication, appeared to be less susceptible to IFN-β than the HN gene. This selective action of IFN-β did not appear to be attributable to its well characterized antiviral mechanisms such as acceleration of RNA decay and translation inhibition. No similar down-regulation of a particular gene expression was found with another paramyxovirus, Sendai virus, or with a rhabdovirus, vesicular stomatitis virus, or seems to have been reported previously with any negative-strand RNA viruses. This new effect of IFN-β thus suggests gene expression mechanism unique to NDV and may further lead to the discovery of a novel biochemical effect of IFN-β.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00216789
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