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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 12 (1988), S. 635-640 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le but de cette étude était de comparer, chez le rat, la circulation sanguine et les réactions tissulaires après fermeture cutanée par agrafes métalliques d'une part, et par points séparés de nylon ou de soie, d'autre part. Le débit de la microcirculation a été mesuré dans chaque couche de peau, y compris au niveau de l'incision, pendant 6 jours. Les modifications macroscopiques ont été étudiées 2 heures après la fermeture et les modifications microscopiques 6 jours après. Le débit sanguin de la peau normale était plus élevé dans le corps papillaire du derme. Le débit sanguin des tissus fermés par agrafes a commencé à augmenter une heure après la fermeture et a continué pendant les 6 jours, ce qui suggère une régénération capillaire active. Le débit sanguin des tissus suturés avec du nylon a commencé à augmenter au 3ème jour, après une baisse importante initiale. Une tendance similaire s'est dessinée lorsque la plaie a été fermée avec de la soie, mais la baisse initiale était plus prononcée, et le débit sanguin n'avait pas atteint le niveau de départ au 6è jour. La cicatrisation était complète, la couleur de la peau normale, et la ligne de suture presque invisible au 6ème jour lorsque la plaie avait été fermée par agrafes. Lorsque la peau avait été fermée par des points de nylon, on voyait une anoxie tissulaire 2 heures après, mais au 6ème jour, l'aspect était semblable aux plaies fermées par des agrafes. Six jours après, les sites de passage de points de soie étaient oedématiés et sombres. Du point de vue histologique, il n'y avait pas d'hypertrophie de l'épiderme régénéré au niveau de la ligne de suture. Par contre, dans le groupe nylon, on a constaté une hypertrophie légère de l'épiderme, des cellules inflammatoires dans les tissus sous-cutanés et de l'oedème autour de la plaie. Le débit sanguin et la cicatrisation sont donc tout à fait satisfaisants en cas de fermeture par agrafes.
    Abstract: Resumen El propósito de este estudio fue comparar el flujo sanguíneo y la reacción tisular después del cierre de la herida quirúrgica con ganchos metálicos (staples) o con suturas interrumpidas de nylon o de seda. El flujo microsanguíneo fue medido en un período de 6 días en cada capa de la piel normal y en el lugar de la incisión. Los cambios macroscópicos en las incisiones cutáneas fueron valorados 2 horas después de completado el cierre, y a los 6 días se tomaron especímenes tisulares para examen histológico. Las mediciones de flujo sanguíneo en la piel normal demostraron un valor máximo en el stratum papillare del corium. El flujo sanguíneo en el tejido de la herida cerrada con ganchos metálicos aumentó de su valor de base a la hora y continuó el aumento a lo largo del período de 6 días, lo cual sugiere regeneración activa de nuevos capilares. El flujo sanguíneo en las ratas suturadas con nylon disminuyó en forma marcada a niveles inferiores a los de base, pero luego aumentó después de 3 días y 6 días. Similar patrón fue observado en las heridas cerradas con seda, aunque la disminución inicial fue mayor y el flujo no llegó a superar el nivel basal a los 6 días. El proceso de cicatrización apareció completo a los 6 días después del cierre con ganchos, con una piel de aspecto normal, y la incisión apenas visible. La herida cerrada con nylon exhibió anoxia de los tejidos a las 2 horas, pero a los 6 días su apariencia era similar a la de la herida cerrada con ganchos. A los 6 días del cierre, la herida suturada con seda apareció edematosa, de color oscuro, y apretada. Los hallazgos histológicos demostraron ausencia de hipertrofia de la epidermis generada en el sitio del cierre con ganchos. La herida cerrada con nylon demostró hipertrofia leve de la epidermis, la presencia de células inflamadas en los tejidos subcutáneos, y edema menor. Se llega a la conclusión de que el flujo sanguíneo y el proceso de cicatrización son óptimos cuando se utilizan ganchos metálicos para el cierre de la herida.
    Notes: Abstract The purpose of this study was to compare blood flow and tissue reaction in rats following wound closure with either staples or interrupted sutures using nylon pr silk. Microblood flow over a period of 6 days was measured in each layer of normal skin and at the incision site, Macroscopic changes in skin incisions were evaluated 2 hours after closure and 6 days after closure for histologic examination. Measurements of blood flow in normal skin showed the greatest amount of the stratum papillare of the corium. Blood flow in wound tissue closed with staples increased from baseline after 1 hour and continued over the 6-day period, suggesting active regeneration of new capillaries. Blood flow in rats sutured with nylon decreased markedly to below baseline value, but increased after 3 days and 6 days. A similar trend occurred in wounds closed with silk although the decrease was greater and blood flow did not increase above the baseline at 6 days. Wound healing was complete 6 days after closure with staples, skin color normal, the incision hardly discernible. The wound sutured with nylon showed anoxia of tissue after 2 hours, but at 6 days, appeared similar to the stapled wound. Six days after closure, the silk suture site was swollen, dark in color, and tight. Histologic findings revealed no hypertrophy of the regenerated epidermis at the stapled suture site. The nylon group showed slight hypertrophy of the epidermis, inflamed cells in the subcutaneous tissues, and slight edema at the wound site. It is my conclusion that blood flow and wound healing are most satisfactory when staples are used for wound closure.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 3 (1979), S. 215-220 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Nous avons dosé l'acide et la pepsine dans le suc gastrique et mesuré les concentrations de pepsine dans la muqueuse du corps gastrique chez 4 malades gastrectomisés pour hémorragie sur érosion gastrique aiguë (“ulcère de stress”) et chez 30 patients gastrectomisés pour ulcère gastrique ou duodénal chronique. Chez les malades atteints d'ulcère de stress, les concentrations de pepsine dans la muqueuse fundique sont nettement plus élevées que chez les patients atteints d'ulcère gastroduodénal chronique. De plus, dans l'ulcère de stress, les concentrations de pepsine dans le suc gastrique et la sécrétion acide sont nettement plus basses et les taux sanguins de corticostéroïdes sont plus élevés. Le rapport des concentrations en pepsine dans la muqueuse et dans le suc gastrique est donc plus élevé en cas d'ulcère de stress. Il est possible qu'une élévation brutale des taux de corticostéroïdes endogènes augmente la concentration intracellulaire de pepsine dans la muqueuse fundique, et ce phénomène joue peut-être un rôle dans la pathogénie de l'ulcère de stress.
    Notes: Abstract Measurements of acid and pepsin in gastric juice and the pepsin concentration in the fundic mucosa were performed in 4 patients who underwent partial gastrectomy for bleeding from acute gastric mucosal erosions (“stress ulcers”) and in 30 patients who underwent partial gastrectomy for chronic gastric or duodenal ulcers. The most striking finding was a significantly higher level of fundic mucosal pepsin in the patients with acute gastric erosions than the chronic ulcer patients. This finding was associated with a significantly lower concentration of pepsin in gastric juice, a low level of acid secretion, and the expected high plasma level of corticosteroids associated with stress. As a result, the ratio of gastric mucosal pepsin to gastric juice pepsin was significantly higher in patients with acute gastric erosions than in those with chronic ulcers. It is possible that a rapid increase in endogenous corticosteroid levels induces an increase in intracellular pepsin in the fundic mucosa, and that this sequence of events plays a role in the pathogenesis of stress ulcer.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Surgery today 10 (1980), S. 137-141 
    ISSN: 1436-2813
    Keywords: Barrett's esophagus ; adenocarcinoma of the esophagus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of signet ring cell carcinoma of the lower thoracic esophagus of Barrett type without association of hiatus hernia is reported. The patient is doing well more than five years after esophagectomy combined with esophagogastrostomy. On the base of histological findings of the operative material, this tumor appears to have originated from the gastric type of mucosa with parietal cells, accessory cells and chief cells as it is lining the segment of the esophagus directly distal to the tumor. The basic anomaly in this case is believed to be misdifferentiation of the embryonic columnar epithelium to a gastric fundic type instead of a normal squamous type.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1436-2813
    Keywords: fucosylated antigens ; murine monoclonal antibody ; colorectal carcer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A monoclonal antibody, YB-2, which has a novel epitope for fucosylated antigens and shows cross-reactivity with Y/Leb/H type 2 antigens, was used in an immunohisto-chemical study of human neoplastic and normal colorectal tissues. Of 64 colorectal cancers, 59 (92.2%) were stained by the YB-2 antibody; however, only 3 (12.0%) of 25 samples of normal colon mucosa and 13 (50.0%) of 26 adenomas expressed the antigens recognized by YB-2. Clinicopathologically, the YB-2-negative colon cancers were exclusively in Dukes stage A. These results indicate that the monoclonal antibody, YB-2, could detect cancer-associated antigens, and the degree of YB-2-reacted antigen expression might be correlated with the progression of colorectal carcinogenesis.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1436-2813
    Keywords: colon motility ; transverse colon transplant ; total gastrectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The motor activity of the isolated colon is under-stood less than that of any other part of the gastrointestinal viscus. Thus, the aim of the present study was to evaluate the motor activity of the interposed transverse colon following total gastrectomy through a study of 21 patients. Manometric studies were carried out with a 5-lumen, open-tipped catheter in the resting state, in response to dry swallows, and swallowing distilled water and a liquid meal. Contractile waves in the interposed colon grafts were divided into three types, namely, high-amplitude propagated contractions (HAPCs), low-amplitude propagated contractions (LAPCs), and low-amplitude nonpropagated contractions (LANPCs). No retrograde contractions were observed during the entire recording. Motor activity in the interposed colon increased to a greater extent after swallowing distilled water or liquid meals than during the resting period or after dry swallows; however, there was no significant difference between the effect of distilled water and liquid meals. The motor activity of the interposed colon was lower in patients with symptoms than in asymptomatic patients. These results suggest that the volume, rather than the composition, of the lumen contents is an important factor for inducing interposed colon graft contractions, and that contractions of the interposed colon can help to propel the contents of the colon into the duodenum and clear any duodenal juice if reflux should occur.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1436-2813
    Keywords: Key Words: colon motility ; transverse colon transplant ; total gastrectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Surgery today 3 (1973), S. 212-217 
    ISSN: 1436-2813
    Keywords: thyroid adenoma ; Hürthle cell change ; identical twins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recurrences occurring in twelve-year female identical twins 5 years after surgery for thyroid adenoma were reoperated. Both were shown to have Hürthle cell adenoma but one with a malignant potential. Microscopic study of these exceptional cases indicated that long-term follow-up is necessary before assuming benign nature of the tumor.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1435-5922
    Keywords: Key words: glucagon ; motility ; side effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Glucagon is commonly used during gastrointestinal examinations for the temporary inhibition of gastroduodenal movements. Three preparations of glucagon are now clinically available: those prepared by extraction from the pancreas (GL-P), by chemical synthesis (GL-S), and by genetic recombination (GL-G). The aim of this study was examine the mechanism of the inhibitory effect of glucagon on gastrointestinal motility and the cause of its side effects by comparing three glucagon preparations. In four conscious dogs, gastrointestinal contractions were monitored by means of chronically implanted force transducers. Each glucagon preparation (GL-P [15 μg/kg], GL-S [5, 15, 45 μg/kg], GL-G [15 μg/kg]), scopolamine butylbromide (0.4 mg/kg), or saline was administered intravenously 20 min after the termination of spontaneous phase III contractions, and blood samples were taken at 5- to 10-min intervals. Barium was administered into the stomach 10 min after the infusion of each drug. The arrival of a barium meal in the stomach immediately stimulated gastrointestinal contractions, and the barium meal was expelled into the duodenum and jejunum from the stomach. Intravenous injection of 15 μg GL-S first stimulated duodenal contractions that propagated to the jejunum, followed by strong inhibition of the barium-induced gastrointestinal contractions. This inhibitory effect of glucagon and the activity of the glucagon-induced duodenal contractions were dose-related. The inhibitory effects of GL-G and GL-S were stronger than that of GL-P. Blood glucose and plasma insulin concentrations were raised after intravenous injection of each glucagon preparation, but there was no difference among the three preparations and no dose relationship. The inhibitory effects of glucagon depend on the material purity and dose, and the inhibitory mechanism was independent of any effect on carbohydrate metabolism. Glucagon administration caused phase III-like contractions in the duodenum and jejunum, which may be responsible for the side effects of glucagon.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1436-2813
    Keywords: peptic ulcer ; gastric secretion ; serum cortisol ; gastrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Measurements of serum cortisol and gastrin along with gastric acid-pepsin secretion in the resting state were carried out in gastric and duodenal ulcer patients. Increased basal corticosteroid concentrations were observed in patients with duodenal ulcer and gastric ulcer. Higher concentrations of the hormone were observed in the former group (P〈0.05 for the latter). Fasting gastrin levels were significantly higher in gastric ulcer patients where gastric secretion is low than those in duodenal ulcer patients (P〈0.001). These results suggest that the effect of adrenal cortical hormone on lowering the threshold of oxyntic gland cell reactivity against gastrin is an important factor in duodenal ulcer etiology. Extra-antral control mechanism(s) of gastric acid-pepsin secretion should not be overlooked.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1436-2813
    Keywords: adenocarcinoma ; fecal incontinence ; abdominoperineal pull-through ; imperforate anus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An extremely rate case is presented here, of an adenocarcinoma at the site of a long-standing perineal wound, the presence of which was a result of a pull-through procedure for imperforate anus. Wide local excision of a huge mass, including the perineal skin and the distal rectosigmoid segment, was carried out en-bloc on a 35 year old male. This tumor may have been caused by the repeated trauma and frequent ulceration around the perineal wound as a result of poor hygiene due to a fecal incontinence.
    Type of Medium: Electronic Resource
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