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  • 1
    Electronic Resource
    Electronic Resource
    Histaminergic H2 Action Protects Hippocampal CA1 Neurons by Prolonging the Onset of the Anoxic Depolarization in Gerbils (1996)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 67 (1996), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The central histaminergic action on ischemia-induced neuronal damage was examined by evaluating the histological outcome and the direct current (DC) potential shift in the hippocampal CA1 region in gerbils. An intracerebroventricular administration of histamine (10–100 nmol) improved the delayed ischemic damage in hippocampal CA1 pyramidal cells produced by 3 min of transient forebrain ischemia. A high dose (75 nmol) of mepyramine, an H1 antagonist, aggravated ischemia-induced neuronal damage, but not a low dose (0.75 nmol). Administration of cimetidine (4 nmol) and ranitidine (3 nmol), H2 antagonists, aggravated the neuronal damage. An injection of histamine (100 nmol) prolonged the onset time of the ischemia-induced sudden shift in the extracellular DC potential (anoxic depolarization; AD) to 133% of that in control animals. Administration of mepyramine (75 nmol) did not markedly change the AD, whereas injections of cimetidine (40 nmol) and ranitidine (3 nmol) reduced the onset latency to 47 and 45%, respectively. These findings suggest that the central H2 action serves to protect neurons by delaying the onset of AD in gerbils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1996.67062613.x
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  • 2
    Electronic Resource
    Electronic Resource
    Prostaglandin E1 improves hepatic encephalopathy produced by ischaemia-reperfusion liver injury in rats (2000)
    Springer
    Intensive care medicine 26 (2000), S. 1681-1684 
    Details
    ISSN: 1432-1238
    Keywords: Hepatic encephalopathy Liver ischaemia Passive avoidance Prostaglandin E1 Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: To investigate the action of prostaglandin E1 on hepatic encephalopathy. Design: Prospective, randomised, controlled animal study. Setting: University animal laboratory. Subjects: Male Wistar rats. Interventions: After passive avoidance learning, acute liver failure was induced by occlusion of the left portal vein and the hepatic artery for 90 min. Then memory retention was evaluated 48 h later. The effects of prostaglandin E1 on memory retention were examined in animals treated with the agent systemically (intravenous injections with prostaglandin E1 twice before and after surgery, 20 µg/kg each time) and animals treated with the agent topically (intracerebroventricular injection with prostaglandin E1, 0.1 µg/h for 48 h beginning at liver ischaemia). Measurements and results: Marked damage was found on plasma analysis in animals subjected to liver ischaemia, and the memory retention was also impaired. Intravenous administration of prostaglandin E1 improved both the liver injury and memory retention. However, intracerebroventricular administration of prostaglandin E1 alleviated neither. Conclusion: These findings show that prostaglandin E1 contributes to the amelioration of hepatic encephalopathy by improving liver function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340000690
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Nasotracheal intubation using fiberoptic bronchoscopy in infants and children (1989)
    Springer
    Journal of anesthesia 3 (1989), S. 103-104 
    Details
    ISSN: 1438-8359
    Keywords: Pediatric intubation ; Fiberoptic bronchoscopy ; Infant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054090030103
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Misplacement of an epidural catheter via intervertebral foramen is not rare (1995)
    Springer
    Journal of anesthesia 9 (1995), S. 209-209 
    Details
    ISSN: 1438-8359
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02479864
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    An analysis of flow volume curves during artificial ventilation (1993)
    Springer
    Journal of anesthesia 7 (1993), S. 120-123 
    Details
    ISSN: 1438-8359
    Keywords: Flow volume curve ; Artificial ventilation ; Monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Expiratory flow-volume curves during artificial ventilation (FV-av) were analyzed in 48 patients undergoing general anesthesia. They were divided into 4 groups according to preoperative respiratory disorders; obstructive type (group 1), restrictive type (group 2), small airway disease (group 3) and normal control (group 4). Expiratory flow rates and volumes during artificial ventilation were plotted on an X-Y recorder to calculate V¨50/V¨25, mean time constant ratio (MTCR), obstructive index (OI) and slope ratio (SR). FV-av values were compared among groups. FV-av values in groups 2 were significantly higher than those in group 4. The values in group 1 and those in group 3 were not significantly different from those in group 4. FV-av values may reflect restrictive respiratory dysfunctions but they are not sensitive enough to detect obstructive lung disease. (Ochi G, Kojo H, Yorozuya T, et al.: An analysis of flow volume curves during artificial ventilation. J Anesth 7: 120–123, 1993)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054030070120
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  • 6
    Electronic Resource
    Electronic Resource
    The patency of the airway via each upper airway orifice during general anesthesia (1995)
    Springer
    Journal of anesthesia 9 (1995), S. 15-16 
    Details
    ISSN: 1438-8359
    Keywords: Airway ; Mouth ; Nostril ; General anesthesia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The patency of the airway via each orifice was examined during general anesthesia in 112 patients by occluding other orifices in order to develop a method in which fiberoptic endotracheal intubation (FEI) and ventilation could be performed via different orifices. Ventilation was well maintained via the mouth in 61 (54.5%), via bilateral nostrils in 87 (77.7%), and via the unilateral right and left nostril in 67 (59.8%) and 73 (65.2%) patients, respectively. With the aid of an artificial airway, ventilation was well maintained via the mouth in 112 (100.0%), via bilateral nostrils in 111 (99.1%), and via the unilateral right and left nostril in 106 (94.6%) and 105 (93.8%) patients, respectively. Based on these findings, we developed a method in which FEI is performed via the nostril, while ventilation is performed with a mask applied over only the mouth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02482028
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    Paper (German National Licenses)
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