ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Official methods of analysis
;
Method evaluation
;
Minocycline
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The liquid chromatographic methods laid out for the analysis of minocycline hydrochloride in the British Pharmacopoeia 1988, the United States Pharmacopeia XXII and the Pharmacopée Française 10 were examined. The major difference between these methods lies in the adjustment of the pH of the mobile phase. The analyst has to obtain the right pH of the mobile phase for his available column. This was found to be a less than easy task for the occasional analyst. Other disadvantages observed were poor solubility of the components of the mobile phase, reduced sensitivity due to UV absorbance by the mobile phase, rather high back pressure, the elution order for 9-minocycline depending on the brand of stationary phase, and above all, poor stability of the stationary phase.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02262248
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