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  • 1
    Electronic Resource
    Electronic Resource
    Unusual variant of left paraduodenal hernia herniated into the mesocolic fossa leading to jejunal strangulation (1998)
    Springer
    Journal of gastroenterology 33 (1998), S. 734-738 
    Details
    ISSN: 1435-5922
    Keywords: Key words: internal hernia ; paraduodenal hernia ; mesocolic fossa ; computed tomography ; diagnostic imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Paraduodenal hernia is a rare condition in which the small bowel loops are herniated into an unusual fossa in the periduodenal area. We treated a patient with paraduodenal hernia diagnosed pre-operatively. A 28-year-old woman was admitted to our hospital because of intermittent abdominal pain. Abdominal ultrasonography revealed a large tumor adjacent to the pancreas. Provisional diagnosis made according to computed tomography (CT) findings was tumor of the pancreas tail. However, on a CT scan performed after the administration of diatrizoate meglumine/diatrizoate sodium (Gastrografin, Schering, Berlin, Germany) the mass was shown as a jejunum loop located between the stomach and the pancreas body. Subsequent laparotomy revealed that the jejunum loop was herniated into an unusually large mesocolic fossa and that the hernial orifice was covered by the adhesion between the transverse and descending colons. It seemed that the small intestine within the mesocolic fossa was strangulated by this adhesion. The patient's abdominal pain resolved postoperatively. These observations suggest that paraduodenal hernia should be suspected in patients with chronic, atypical abdominal pain, regardless of the findings for small bowel obstruction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350050164
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  • 2
    Electronic Resource
    Electronic Resource
    In vitro colony inhibition of carboplatin against stomach and lung cancer cell lines in comparison with cisplatin (1987)
    Springer
    Cancer chemotherapy and pharmacology 19 (1987), S. 197-200 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of carboplatin and cisplatin on colony formation in stomach and lung cancer cell lines were examined and compared. The colony-inhibitory activity of carboplatin against stomach and lung cancer cell lines was similar to that of cisplatin when one-tenth of the peak plasma concentration of each drug was used (r=0.80). One of the four stomach cancer cell lines was sensitive to carboplatin although all the stomach cancer cell lines were resistant to cisplatin. Of the three small cell lung cancer cell lines tested, two were sensitive to both carboplatin and cisplatin; and only one cell line (N857) was resistant to cisplatin; all the non-small cell cancer cell lines tested were resistant to both drugs. On the basis of these preliminary results, we suggest that carboplatin has potential therapeutic activity against stomach cancer and should be evaluated carefully from this aspect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252972
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  • 3
    Electronic Resource
    Electronic Resource
    In vitro antitumor activity of mitomycin C derivative (RM-49) and new anticancer antibiotics (FK973) against lung cancer cell lines determined by tetrazolium dye (MTT) assay (1988)
    Springer
    Cancer chemotherapy and pharmacology 22 (1988), S. 246-250 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven small- (SCLC) and four non-small-cell (NSCLC) lung cancer cell lines were used to examine the in vitro cytotoxicity of cytotoxic drugs such as (1aS-(1aα,8β,8aα,8bα))-8-((aminocarbonyl)oxy)methyl-4,8a-dimethoxy-1,1a,2,8,8a,8b-hexahydro-7-hydroxy-5-methyl-6-nitrosoazirino(2′,3′: 3,4)-pyrrolo-(1,2-a)indole (RM-49) and 11-acetyl-8-carboxymethyl-4-formyl-14oxa-1, 11-diazetetracyclo(7.4.1.02,7,010,12)tetradeca-2-4-6-trien-6,9-diyl-diacetate (FK973). In vitro cytotoxicities of RM-49 and FK973 were compared with those of mitomycin C (MMC), cisplatin (CDDP), carboplatin (CBDCA), etoposide (VP16), adriamycin (ADM) and vindesin (VDS). Drug sensitivity was determined using a tetrazolium (MTT)-based assay. Average IC50 values of these two drugs were not statistically different compared with that of MMC, although FK973 showed strong antitumor activity against SCLC cell lines such as LT3, N857, and H69 at the same concentration. The predicted peak plasma concentration (predicted PPC) calculated by the formula proposed by Scheithauer, log (predicted PPC) =-0.788+(0.755×log(LD50)), and relative antitumor activity, RAA (PPC/IC50), of RM-49 were higher than those of other drugs such as MMC, CDDP, CBDCA, and ADM against SCLC cell lines (P≦0.05), and those of FK973 were also higher than those of other drugs such as MMC, CDDP, CBDCA, and ADM against SCLC cell lines (P≦0.05). Based on these promising in vitro studies, the clinical trials of RM-49 and FK973 were warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273419
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  • 4
    Electronic Resource
    Electronic Resource
    The different effects of recombinant human tumor necrosis factor on rat fibrosarcoma sublines (1987)
    Springer
    Cancer immunology immunotherapy 24 (1987), S. 185-189 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antitumor effect of recombinant human tumor necrosis factor (rH-TNF) on two clones of rat fibrosarcoma with different metastatic potential to lymph nodes was examined. The colony formation of clone A, which has high metastatic potential, was completely inhibited by continuous exposure to rH-TNF at 50 U/ml. In contrast, colony formation of clone G, which has low metastatic potential, was not inhibited by high concentrations of rH-TNF (10,000 U/ml). The inhibitory effect of rH-TNF on colony formation by clone A was also observed with a 1-h exposure to rH-TNF. This effect was time and concentration dependent, as determined by the colony assay, 3H-thymidine uptake assay, and 51Cr-release assay. 3H-thymidine and 3H-uridine uptake per cell of clone A exposed to rH-TNF was not decreased. This suggests that the mechanisms of the antitumor effect of rH-TNF were not due to inhibition of DNA and RNA synthesis of tumor cells. In vivo growth and lymph node metastases of clone A inoculated i.p. to Donryu strain rats were completely suppressed by 14 consecutive i.p. injections of 105 or 106 U/kg per day of rH-TNF. On the other hand the growth of clone G was not influenced by rH-TNF administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205627
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  • 5
    Electronic Resource
    Electronic Resource
    Comparative study of the antitumor effect of two types of murine recombinant interferons, (β) and (γ), against B16-F10 melanoma (1988)
    Springer
    Cancer immunology immunotherapy 26 (1988), S. 109-113 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A comparative study of the antitumor effect of murine recombinant interferon(β) 〈Mu-rIFN(β)〉 and murine recombinant interferon(γ) 〈Mu-rIFN(γ)〉 on B16-F10 melanoma was conducted. Administration of Mu-rIFN(γ) i.p. into C57BL/6 mice on days 1 to 7 produced a higher suppressive effect than Mu-rIFN(β) both on the growth of s.c. implanted tumor and on the formation of artificial pulmonary metastasis. Pharmacokinetic study of Mu-rIFN(γ) demonstrated that high plasma levels were retained for a long time. In clonogenic assay, Mu-rIFN(γ) at 1000 units/ml showed about 80% inhibition of colonies of B16-F10 melanoma. However, Mu-rIFN(β) hardly inhibited the colonies, even at 1000 units/ml. Augmentation of natural killer (NK) cytotoxicity was much greater with Mu-rIFN(β) than Mu-rIFN(γ), whereas Mu-rIFN(γ) enhanced the cytotoxicity of peritoneal macrophages more strongly than Mu-rIFN(β). Injection of Mu-rIFN(γ) i.p. 1 day before tumor challenge also inhibited the formation of pulmonary metastasis of B16-F10 melanoma. However, pretreatment of mice with carrageenan significantly suppressed the inhibitory effect of Mu-rIFN(γ). From these results, it is suggested that the inhibitory effect of Mu-rIFN(γ) on the tumor growth and metastases of B16-F10 melanoma is mediated partly by direct antitumor effect and partly by the activation of macrophages, and that the augmentation of NK activity contributes mainly to the antitumor effect of Mu-rIFN(β).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205602
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  • 6
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of (glycolato-0,0′)-diammine platinum (II), a new platinum derivative, in comparison with cisplatin and carboplatin (1989)
    Springer
    Cancer chemotherapy and pharmacology 23 (1989), S. 243-246 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetics of (glycolato-0,0′)-diammine platinum (II) (254-S; NSC 375101D), one of the new platinum analogues, was examined in a phase I study of this drug and compared with that of cisplatin and carboplatin. All drugs were given in short-term (30-min) i.v. drip infusions; the doses of 254-S, cisplatin, and carboplatin were 100, 80, and 450 mg/m2, respectively. Platinum concentrations in whole plasma, plasma ultrafiltrate, and urine were determined by atomic absorption spectrometry. After the infusion, the plasma concentration of total platinum for the three agents decayed biphasically. Ultrafilterable platinum in plasma decreased in a biexponential mode after infusions of 254-S and carboplatin, whereas the free platinum of cisplatin showed a monoexponential disappearance. The peak plasma concentrations and AUC for free platinum were 5.31 μg/ml and 959 μg/min per ml for 254-S, 3.09 μg/ml and 208 μg/min per ml for cisplatin, and 19.90 μg/ml and 3446 μg/min per ml for carboplatin, respectively. The mean ratio of plasma ultrafilterable platinum to total platinum were calculated, and the results showed that the protein-binding abilities of 254-S and carboplatin were almost identical. More than 50% of the 254-S was excreted in the urine within the first 480 min after its administration. Thrombocytopenia was reported as a dose-limiting toxicity for both 254-S and carboplatin. This similarity in side effects may mainly be due to the comparable pharmacokinetic behavior of these two platinum compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451649
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  • 7
    Electronic Resource
    Electronic Resource
    Cytogenetic effect of carboplatin on human lymphocytes (1988)
    Springer
    Cancer chemotherapy and pharmacology 21 (1988), S. 203-207 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Carboplatin, a second generation cisplatin analogue, was tested for induction of sister chromatid exchange (SCE) as well as chromosomal aberrations in human lymphocytes in vitro and in vivo. A dose-dependent effect was observed for increased frequency of metaphases with SCE (r=0.984, P(0.001) as well as chromosomal aberrations (r=0.994, P(0.001), primarily chromatid gap or break, in vitro. SCE induction by carboplatin was less than that by cisplatin at the same concentration. When patients were treated with a single dose of carboplatin at a dose of 450 mg/m2, the frequency of SCE and chromatid type aberrations increased significantly. However, even when considering dose and peak plasma concentration in patients receiving carboplatin, it appears that the ability of carboplatin to induce SCE and chromosomal aberrations is weaker than that of cisplatin. SCE frequencies induced by carboplatin decreased with time going by, and in one patient who was tested 5 weeks after treatment, SCE frequency showed a decrease to the pretreatment level. It thus appears that carboplatin has an improved therapeutic index over the parent compound, cisplatin, because of its less mutagenic or carcinogenic hazard, in addition to the largely reduced incidence of untoward effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262770
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  • 8
    Electronic Resource
    Electronic Resource
    Immunohistochemical detection of anti-(±)-trans-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene-bound adduct in nuclei of cultured HeLa cells and mouse lung tissue (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 225-230 
    Details
    ISSN: 1432-1335
    Keywords: Benzo(a)pyrene ; Carcinogen-DNA binding ; Adduct antibody ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rabbit IgG against anti-BP-DE-modified calf thymus DNA was characterized and utilized for detection of adducts formed in cultured HeLa cells treated with anti-BP-DE or in lung tissues from mice given BP. Four weekly treatments with 1 mg of the modified (1.2% of total nucleotides) DNA were used to raise the rabbit antiserum, which even at 106-fold dilution clearly recognized adducts in an ELISA. The detection limit was 25 fmol of anti-BP-DE adduct with 103-fold diluted IgG fraction. The IgG did not cross-react with BP, BP tetraol, guanine, or 7-methyl-guanine, and only slightly with the syn form of BP-DE, (±)-4,5-dihydrobenzo(a)-pyrene-4,5-epoxide, aflatoxin B1, and N-methyl-N-nitrosourea-modified DNA. Although syn-BP-DE-modified DNA inhibited the reaction between IgG and anti-BP-DE adduct, the inhibition rate was low, not correlating with the numbers of modified bases. Essentially similar values for level of bound adducts in HeLa cells treated with anti-BP-DE were generated by both ELISA and associated radioactivity derived from anti-3H-BP-DE. Immunohistochemical detection of adduct formation was dependent on the amounts of anti-BP-DE added to the culture medium of HeLa cells. Similar positive binding was obtained in mouse lung alveolar cell nuclei after intragastric administration of BP. These observations indicate that the prepared IgG is highly specific for anti-BP-DE-modified DNA and that should prove useful for detection of adducts formed in tissue samples exposed to anti-BP-DE or BP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405826
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  • 9
    Electronic Resource
    Electronic Resource
    Prognostic factors in non-small cell lung cancer: multiregression analysis in the National Cancer Center Hospital (Japan) (1987)
    Springer
    Journal of cancer research and clinical oncology 113 (1987), S. 563-566 
    Details
    ISSN: 1432-1335
    Keywords: Non-small cell lung cancer ; Prognostic factors ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 190 patients with unresectable non-small cell lung cancer (NSCLC) were analyzed retrospectively using eight pretreatment and three treatment-related prognostic factors in terms of influence on survival. All the patients received chemotherapy with or without chest irradiation, according to the protocol of phase II or phase III trials of the National Cancer Center Hospital Tokyo between April 1980 and December 1985. The eight pretreatment factors selected were performance status, sex, stage, age, histology, and metastasis to brain, bone or, liver. Three treatment-related factors were radiation therapy to the primary site, response to chemotherapy, and treatment period, before or after clinical adminsitration of cis-diamminedichloroplatinum (II) (CDDP). Of the 190 patients, 71 (37.4%) were alive for more than 1 year, but only 17 patients (8.9%) survived 2 years after the initiation of chemotherapy. By univariate analysis, performance status 0–1, female, no metastasis to bone or liver, response to chemotherapy, and treatment period after CDDP were considered to be favorable prognostic factors. By multiregression analysis, performance status, sex, and treatment period after CDDP proved to be important factors for long-term survival. Consideration of these prognostic factors could enable the results of chemotherapy to be more accurately evaluated, and stratification of patients with advanced NSCLC based on performance status and sex before entry into a randomized controlled trial is recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390866
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  • 10
    Electronic Resource
    Electronic Resource
    Participation of poly(ADP-robose) polymerase in the drug sensitivity in human lung cancer cell lines (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 244-248 
    Details
    ISSN: 1432-1335
    Keywords: Poly(ADP-ribose) polymerase ; Drug resistance ; Lung cancer cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Poly(ADP-ribose) polymerase has been generally assumed to be involved in DNA repair. The level of the enzyme in various lung cancer cell lines was examined to determine if it is involved in drug resistance. Among nine cell lines of lung cancer tested, small-cell lung cancer lines, which showed higher sensitivity to cisplatin and etoposide, were unexpectedly found to contain significantly higher poly(ADP-ribose) polymerase activity than five non-small-cell lung cancer cell lines. This activity inversely correlated with IC50 values of lung cancer cell lines to etoposide, an inhibitor of topoisomerase II. The polymerase activity was also examined in several cisplatin-resistant variants of the cell lines. However, no difference was observed between parental and cisplatin-resistant cells. There was no significant relation between poly(ADP-ribose) polymerase activity and IC50 values for cisplatin and carboplatin. Although this enzyme was considered to play some role in the resistance to specific drugs, it might not be a critical factor in cisplatin-induced cytotoxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01208612
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