ISSN:
1619-7089
Keywords:
Slant hole collimator
;
Gamma camera
;
Atraumatic rCBF measurement
;
133Xe
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The purpose of this study is to develop a useful gamma camera system for atraumatic rCBF measurement by the133Xe intravenous injection (i.v.) method. A super high sensitivity slant hole (SHS-SL) collimator was designed for this purpose. The gamma camera used with this collimator was able to move close to the patient's head and obtain satisfactory count rates (130 kcpm–178 kcpm in a hemisphere) with a low dosage (10 mCi) of133Xe. To validate this rCBF measurement system three studies were carried out: a comparative evaluation was performed against the flow values with the intracarotid133Xe injection (i.c.) method, reproducibility of flow values was assessed from two serial i.v. measurements, and flow values were compared with clinical severity of the patients. The comparative study showed good correlation in the hemispheric and regional values between the two methods;r values 0.98 and 0.64–0.93 for gray matter flow and 0.96 and 0.78–0.93 for initial slope index. In the reproducibility study, the variation coefficients in the hemispheric and regional values between the two serial measurements were 5.0% and 7.3%–14.2% for gray mater flow, 5.2% and 7.9%–12.9% for initial slope index. The reproducibility in this study was as good as those with the i.c. method reported previously. The hemispheric flow values from our gamma camera system correlated well with the clinical severity of cerebrovascular disease. These results show that the gamma camera system with the SHS-SL collimator is useful for atraumatic rCBF measurement.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00620475
Permalink
