ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
A mouse plasma substance carrying β2-microglobulin activity and lacking in H-2 alloantigenic activity was separated from the blood plasma of A/J strain female mice. The plasma substance had a molecular size of about 300,000–400,000 daltons and an electrophoretic mobility of α-globulin. The plasma substance was split by papain digestion to a fragment of about 50,000–60,000 daltons that still carried β2-microglobulin activity. The papain-split plasma substance was devoid of H-2 alloantigenic activities and Thy-1 and TL alloantigenic activities as well, but yet had a two-component structure that was similar to papainsolubilized H-2 molecules. It contained a 37,000-dalton component linked non-covalently to an 11,000-dalton component, i.e. mouse β2-microglobulin. This plasma substance appears to be different from Ss protein or Slp protein, both found in mouse serum.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1976.tb00563.x
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