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  • 1
    Electronic Resource
    Electronic Resource
    Diamond-coated sonic tips are more efficient for open debridement of molar furcations (2000)
    Copenhagen : Munksgaard International Publishers
    Journal of clinical periodontology 27 (2000), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/aims: The aim of this study was to compare the efficacy of open debridement of class II and III furcations by a new diamond-coated sonic instrument tip (Sonicparo) with a conventional sonic insert (Sonicrecall) and hand instruments (Gracey curettes).Method: Open debridement was simulated using a manikin head and standardised plastic teeth. The efficacy of debridement was examined by 3 parameters: residual root surface marker, ‘tooth’ weight loss and time taken for debridement. The teeth used were 1st and 2nd upper and lower molars. Upper left and lower right molars were chosen to represent class II furcation involvements and upper right and lower left molars class III furcation involvements. Each tooth was debrided 4 times with each instrument for both class of furcations.Results: The results of this study showed significantly less residual marker area comparing Sonicparo with Gracey curettes (mean difference 2.52 mm2, p〈0.001). However, no significant differences in marker removal were observed between Sonicrecall inserts and the other instruments. Sonicparo inserts also took significantly less time to debride the furcation than Gracey curettes (mean difference 98.3 s, p〈0.001) or Sonicrecall instruments (mean difference 74.3 s, p〈0.001). However no significant differences were found between instruments concerning weight loss of the plastic teeth.Conclusions: It was concluded from this in-vitro study that the Sonicparo insert was a more efficient instrument for open molar furcation debridement than Sonicrecall and hand instruments (Gracey curettes) when considering both marker removal and debridement time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-051x.2000.027005302.x
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  • 2
    Electronic Resource
    Electronic Resource
    Characterisation of bioadhesives for periodontal and oral mucosal drug delivery (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 25 (1998), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. Whilst there is keen interest in developing improved drug delivery devices to the periodontal pocket and oral mucosa, there are few reports which have examined the physical properties of gels and semi-solid formulations which favour retention and bioadhesion in situ. Hydration and rheological properties appear to be of prime importance in this context and this study aimed to correlate the measurement of these properties with observed bioadhesion, both in vitro and in vivo. Three candidate bioadhesives were selected from previous experiments which had used in vitro organ culture models. These were chitosan, xanthan gum and poly (ethylene oxide) aqueous formulations. Hydration rates with various media were determined in specially constructed cells, Rheological properties were measured using a controlled stress rheometer under carefully regulated conditions. These findings were also correlated with in vivo assessments in the periodontal pocket and oral mucosa. The results demonstrated that three formulations with differing bioadhesive properties also possessed widely different physical characteristics. Hydration experiments indicated a direct relationship between the rate of hydration and bioadhesion or retention. Rheological studies suggested that possession of a gel structure could be an important determinant of retention where shear displacing forces are present in vivo. e.g. the oral mucosa. Furthermore, these studies indicated that formulations which could demonstrate resistance to changes in rheological properties on hydration would also favour retention in situ. Physical characterisation therefore appears to have an important place in screening polymeric formulations prior to clinical testing in the periodontal pocket and oral mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.1998.tb02366.x
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  • 3
    Electronic Resource
    Electronic Resource
    Impact of oral health on the life quality of periodontal patients (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 31 (2004), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives: To assess the impact of oral health on the life quality of a periodontal patient group.Materials and Methods: Two hundred and five patients attending a private periodontal clinic completed a questionnaire incorporating the16-item UK oral health-related quality-of-life measure (OHQoL-UK©), a check list of questions about their periodontal health over the past year and a comprehensive periodontal examination.Results: The effect of oral health on quality of life was considerable, with many individuals experiencing negative impacts across a broad range of physical, social and psychological aspects of life quality. OHQoL-UK© scores was associated with patient's self-reported periodontal health in the past year: experiences of “swollen gums” (p〈0.01), “sore gums” (p〈0.01), “receding gums” (p〈0.01), “loose teeth” (p〈0.01), “drifting teeth” (p〈0.01), “bad breath” (p〈0.01) and “toothache” (p〈0.01). In addition, OHQoL-UK© scores were correlated with the number of teeth with pocket depths of 5 mm or more (rs−0.42, p〈0.01). New patients had poorer oral health-related quality of life compared with the treated maintenance group (p〈0.01).Conclusions: Periodontal status impacts on life quality. This has implications in understanding the consequences of periodontal health and in the use of patient-centred outcomes in periodontal research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.2004.00498.x
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  • 4
    Electronic Resource
    Electronic Resource
    Periodontal flap surgery with 25% metronidazole gel (2000)
    Copenhagen : Munksgaard International Publishers
    Journal of clinical periodontology 27 (2000), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to examine the effect of periodontal surgery on PGE2 levels in patients treated for advanced adult periodontitis, with and without application of a 25% metronidazole gel over 12 months follow-up.〈section xml:id="abs1-3"〉〈title type="main"〉Material and methods:The trial employed a randomised controlled, single-blind, parallel arm design on 43 patients with at least 1 pocket probing 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE270307:ges" location="ges.gif"/〉6 mm with bleeding on probing (BOP).Results: The results showed that GCF PGE2 levels showed no significant change following surgical therapy despite marked improvements in clinical periodontal health (p=0.653). No significant differences in the reaction of sites to treatment were detected between test and control groups throughout the study (p=0.709). However, PGE2 levels in GCF were significantly higher in experimental sites compared with healthy untreated sites (negative controls) in both surgery only (p=0.001) and surgery+gel (p=0.023) groups throughout the study.Conclusion: Whilst clear differences were observed between healthy control sites and sites with periodontal breakdown, no effect of treatment on PGE2 levels was discernible in this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-051x.2000.027003193.x
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  • 5
    Electronic Resource
    Electronic Resource
    A rapid spectrophotometric assay for tetracycline in gingival crevicular fluid (2001)
    Copenhagen : Munksgaard International Publishers
    Journal of clinical periodontology 28 (2001), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: The aim of this study was to investigate a rapid spectrophotometric assay for its potential to measure tetracycline levels in gingival crevicular fluid (GCF).Materials and methods: The technique involves complexation of tetracycline with molybdenum in order to shift the absorbance spectrum away from that region where interference with plasma proteins is a problem. The sensitivity of the assay and reproducibility of elution were examined together with an assessment of the effect of plasma proteins. The assay was also tested in a small pilot clinical project, measuring tetracycline levels in GCF following placement of a test gel formulation in 25 periodontal pockets in 5 patients.Results: The in vitro results showed good sensitivity of the assay over the concentration range tested (0.5–200 μg tetracycline) and with little effect of plasma proteins. Elution from the paper strips was reproducible with a good linear correlation between direct and filter absorbed assays (r=0.9989, p〈0.01). The pilot clinical study indicated a mean half-time of tetracycline in GCF of 28 min with confidence intervals of 21 to 34 min, although wide variation between the drug levels of individual periodontal pockets was seen.Conclusions: The results indicate good sensitivity for this assay to measure tetracycline hydrochloride in vivo. The potential for rapidly processing large numbers of samples contrasts with the assay time and limited sample throughput of other methods such as high pressure liquid chromatography (HPLC) and suggests that the technique may be a useful addition to current techniques for measuring tetracycline hydrochloride in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.2001.280108.x
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  • 6
    Electronic Resource
    Electronic Resource
    Systematic review of the effect of smoking on nonsurgical periodontal therapy (2005)
    Oxford, UK : Munksgaard International Publishers
    Periodontology 2000 37 (2005), S. 0 
    Details
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0757.2004.03793.x
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  • 7
    Electronic Resource
    Electronic Resource
    Evidence-based periodontology, systematic reviews and research quality (2005)
    Oxford, UK : Munksgaard International Publishers
    Periodontology 2000 37 (2005), S. 0 
    Details
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0757.2004.37100.x
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  • 8
    Electronic Resource
    Electronic Resource
    A systematic review of guided tissue regeneration for periodontal infrabony defects (2002)
    Oxford, UK : Munksgaard International Publishers
    Journal of periodontal research 37 (2002), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives: To systematically review the evidence for efficacy of guided tissue regeneration (GTR) for infrabony defects.Background: The evidence for the efficacy of GTR has not yet been systematically appraised.Methods: We searched for randomised controlled trials of at least 12 months' follow-up comparing GTR with open flap debridement (OFD). Data sources included electronic databases, hand-searched journals and contact with experts. Screening, data abstraction and quality assessment were conducted independently by multiple reviewers. The primary outcome measure was gain in clinical attachment.Results: For attachment level change, the weighted mean difference between GTR alone and open flap debridement was 1.11 mm (95% CI: 0.63–1.59), chi-square for heterogeneity 31.4 (9 df ), P 〈 0.001) and for GTR + bone substitutes was 1.25 mm (95% CI: 0.89–1.61, chi-square for heterogeneity 0.01 (1 df), P = 0.91). The number of sites needed to treat (NNT) for GTR to achieve one extra site gaining 2 mm or more attachment over open flap debridement was 8 (95% CI: 4–33). Heterogeneity between studies was highly statistically significant for all principal comparisons and could not be explained satisfactorily by sensitivity analyses.Conclusions: Overall, GTR was more effective than OFD in improving attachment levels. However, there was marked variability between studies and general conclusions about the clinical benefit of GTR are limited by this heterogeneity. Future studies should aim to identify factors associated with achieving consistent benefits over open flap debridement. Open flap surgery should remain the control comparison in these studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0765.2002.01369.x
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  • 9
    Electronic Resource
    Electronic Resource
    Evidence-based periodontal disease prevention and treatment: introduction (2005)
    Oxford, UK : Munksgaard International Publishers
    Periodontology 2000 37 (2005), S. 0 
    Details
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0757.2004.03799.x
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  • 10
    Electronic Resource
    Electronic Resource
    Guided tissue regeneration for periodontal intrabony defects – a Cochrane Systematic Review (2005)
    Oxford, UK : Munksgaard International Publishers
    Periodontology 2000 37 (2005), S. 0 
    Details
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0757.2004.37101.x
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