ISSN:
1573-6903
Keywords:
Proline
;
binding
;
brain
;
pipecolic acid
;
glutamate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract There is evidence suggestive of the possible neuromodulatory role forl-proline in the mammalian brain. The binding of proline to whole mouse brain synaptic membranes has been partially characterized. Several binding sites for this imino acid have been identified; one in the nanomolar range and at least two in the submicromolar range. The binding of proline is inhibited by NaCl. Pipecolic acid (40 μM), ornithine, aminooxyacetic acid (AOAA), glycine, GABA, and glutamate were capable of significantly inhibiting proline binding. Although detailed pharmacological and functional studies are needed, these results are consistent with a brain-specific function for this imino acid, as well as, with the presence of specific binding site(s) for proline.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00969628
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