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  • 1
    Electronic Resource
    Electronic Resource
    Studies on isolated corneocytes (1981)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of cosmetic science 3 (1981), S. 0 
    Details
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The function of the stratum corneum is dependent on the functions of its constituent parts. This paper focusses on corneocyte dimensions and the implications of change in dimension for function. A technique in which it is possible to obtain a value for corneocyte thickness is described. The changes in corneocyte dimensions with age and site and after topical applications are documented.Techniques which measure the rate of desquamation are also described. The rate of passive corneocyte loss has been estimated by counting the numbers of corneocytes shed into chambers fixed to the skin surface. In addition the corneocyte loss after a standardized rotational stimulus to the skin surface has been measured. Scanning and transmission electron microscope examination of corneocytes obtained by a scrub procedure is also described. A preliminary report on an immunological approach to the study of the biochemistry of corneocytes and stratum corneum is also included. Etude de cornéocytes isolés
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-2494.1981.tb00289.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of treatment on lymphokine-secreting cells in the intestinal mucosa of children with Crohn's disease (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 9 (1995), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Recent studies have shown both interleukin 2 (IL-2) and interferon gamma (IFN) to be elevated in patients with active Crohn's disease compared to ulcerative colitis or non-inflammatory bowel disease controls. However the effect of treatment on these lymphokines has not been studied. Patients and methods: Using a reverse haemolytic plaque assay the percentage of lymphokine-secreting cells was determined in the intestinal mucosa of children with Crohn's disease before and after 8 weeks of treatment with either enteral nutrition, cyclosporin or steroids. Results: Before treatment, a high percentage of cells isolated from mucosal biopsies secreted IL-2 or interferon-gamma. Eight weeks’treatment with the immunosuppressive agents cyclosporin, or with corticosteroids, produced a significant reduction in the percentage of IL-2 secreting cells, although only for the former was there also a reduction in interferon-gamma secreting cells. Enteral nutrition however, produced a reduction in lymphokine-secreting cells equivalent to cyclosporin and produced the best histological and clinical improvement. Conclusion: Enteral nutrition and cyclosporin can down-regulate lymphokine secretion in the gut in Crohn's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1995.tb00419.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A technique for studying the structural detail of isolated human corneocytes (1980)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 102 (1980), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A technique for the isolation of human stratum corneum cells from any depth within the horny layer is described. Examination of the cells by light, scanning and transmission electron microscope permits a detailed morphological profile of the plasma membrane to be constructed. It is suggested that the technique will be of particular value in determining the effect of chemical agents on the cellular components of the horny layer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1980.tb05673.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The ‘dry’ non-eczematous skin associated with atopic eczema (1980)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 103 (1980), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The non-eczematous but ‘dry’ skin of twelve patients with eczema has been studied and contrasted with skin from similar sites in control subjects of similar age and sex and with patients with autosomal dominant ichthyosis. The areas investigated were examined histologically and by techniques for assessment of the stratum corneum structure and function. The ‘dry’ skin sites demonstrated increased intracorneal cohesion, increased total epidermal thickness, patchy parakeratosis and in places slight hypergranulosis. It is concluded that the dry skin condition of patients with atopic eczema is not autosomal dominant ichthyosis and is probably eczematous in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1980.tb07241.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The change in properties of the stratum corneum as a function of depth (1979)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 100 (1979), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The constancy of stratum corneum thickness suggests an ordered decrease in intracorneal cohesion binding forces. In this study, intracorneal cohesion was measured in the vertical dimension by cohesography and the number of cells released after applying a standardized stimulus was determined before and after repeated stripping of the same sites with adhesive tape. In addition, surface replicas and the corneocytes from different levels were examined by scanning and transmission electron microscopy and differential phase inteference microscopy. The results indicate a gradual loss of cohesion within the stratum corneum towards the surface and that anatomical changes take place in the corneocytes as they progress towards the surface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1979.tb05556.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The dry skin associated with atopic eczema (1978)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 98 (1978), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1978.tb13599.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    The dry skin associated with atopic eczema (1978)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 99 (1978), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1978.tb15219.x
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Novel techniques for the estimation of intracorneal cohesion in vivo (1977)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 96 (1977), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Desquamation is the result of loss of cohesion between horny squames. This study is concerned with the in vivo measurement of intracorneal cohesion using three new techniques. A new instrument, the cohesograph, directly measures the force (g) required to distract a known area of partial thickness of stratum corneum in vivo. Sex and site differences were detected with this method. A surfometer was employed to measure the surface contours of the internal face of skin surface biopsies and when this measurement of the surface irregularity was compared to the ‘cohesograph’ reading for the same sites in 16 normal individuals a significant positive correlation of r = 0·79 was found between the two sets of results. It is therefore suggested that the surfometer provides indirect measure of horny layer cohesion. Desquamation has also been estimated by using a modified ‘scrub technique’. The scrub apparatus used is able to deliver a controlled stimulus to the skin surface to release horny cells. The light absorbance at 400 run of corneocyte suspensions was measured and found to correlate well (r = 0·96) with the numbers of squames released. It is suggested that the three techniques used in conjunction provide a profile of stratum corneum cohesion in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1977.tb05202.x
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Clinical governance: its origins and its foundations (2000)
    Bradford : Emerald
    Clinical performance and quality health care 8 (2000), S. 172-178 
    Details
    ISSN: 1063-0279
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Medicine
    Notes: This article from the NHS Clinical Governance Support Team (NCGST) outlines the development of quality concerns since the NHS was founded in 1948. It traces the development of clinical governance as a means of achieving continuous quality improvement and describes what the implementation of clinical governance means for patients and professionals. It analyses features of the cultural shift necessary to underpin quality improvement initiatives and describes with practical examples the constituents of the culture necessary for successful clinical governance. Future articles in this series will address other issues around clinical governance and will explain the model being followed by delegates to the NCGST's Clinical Governance Development Programme as they implement clinical governance "on the ground".
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/10630270010800813
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  • 10
    Electronic Resource
    Electronic Resource
    Reviewing a service - discovering the unwritten rules (2000)
    Bradford : Emerald
    British journal of clinical governance 5 (2000), S. 233-239 
    Details
    ISSN: 1466-4100
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Medicine
    Notes: In our previous article we looked at the history of quality development and discussed how the implementation of clinical governance provides the opportunity to begin the cultural shift necessary to underpin quality in the modern NHS. This article begins an explanation of the model of quality improvement followed by delegates to the Clinical Governance Development Programme by looking at the service review process delegate teams undertake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/14777270010734073
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    Paper (German National Licenses)
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