ISSN:
1573-4986
Keywords:
glycomimetics
;
C-glycosides
;
glycopeptides
;
chemoselective ligation
;
Aoa, aminooxyacetyl
;
Boc, tert-Butoxycarbonyl
;
Dpr, α,β-L-Diaminopropionic acid
;
DIPEA, Diisopropylethylamine
;
DMF, N,N-Dimethylformamide
;
Fmoc, 9-Fluorenylmethoxycarbonyl
;
PyBOP, Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Deprotected C-glycopyranosyl-ketones have been conjugated by a chemoselective approach to a peptide or an amino acid bearing an aminooxy group on the N-terminus or on the side-chain, respectively. The coupling reaction, performed in aqueous media, does not require protecting groups on the peptide or saccharide moieties, nor auxiliary coupling reagents.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007026527040
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