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  • 1
    Digitale Medien
    Digitale Medien
    The antral gastrin-producing cells in duodenal ulcer patients (1985)
    Springer
    Virchows Archiv 406 (1985), S. 271-277 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Cimetidine ; Duodenal ulcer ; Gastrin producing cells ; Ultrastructure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Ultrastructural examination of the antral G cells has been carried out on 11 patients with chronic duodenal ulcer, before and after treatment with a histamine H-2 - receptor antagonist (cimetidine 1 g/ day) for 8 weeks. The study demonstrated an increased area of the Golgi complex, rough endoplasmic reticulum and electron-dense granules, indicating increased G cell activity during treatment. An increased number of lysosomes was a constant feature during treatment. As an hypothesis we suggest that these lysosomes may participate in the secretory mechanism of human G cells, by destroying superfluous (Gastrin) components produced during hyperactivity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00704296
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    The antral gastrin-producing cells in duodenal ulcer patients (1987)
    Springer
    Virchows Archiv 411 (1987), S. 99-101 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Cimetidine ; Duodenal ulcer ; Gastrin producing cells ; Long-term treatment
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The antral mucosa has been examined in four duodenal ulcer patients before and during long-term, low dose treatment with cimetidine (given a total dose of between 472 g and 894 g). No convincing changes were found in the number or the volume of G cells. Signs of inactivity were demonstrated ultrastructurally, with small granules of intermediate type, a reduced amount of granular endoplasmatic reticulum and Golgi complex, mostly showing no signs of granulogenesis. The occurrence of bundles of cytoplasmic microfilaments, not observed before treatment and the reduced number of D cells may also be signs of inactivity. Hyperplasia and/or neoplasia were not seen in other antral endocrine cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00734521
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
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