Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Branching Morphogenesis During Kidney Development (2000)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 62 (2000), S. 595-620 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Epithelial tissues such as kidney, lung, and breast arise through branching morphogenesis of a pre-existing epithelial structure. They share common morphological stages and a need for regulation of a similar set of developmental decisions-where to start; when, where, and in which direction to branch; and how many times to branch-decisions requiring regulation of cell proliferation, apoptosis, invasiveness, and cell motility. It is likely that similar molecular mechanisms exist for the epithelial branching program. Here we focus on the development of the collecting system of the kidney, where, from recent data using embryonic organ culture, cell culture models of branching morphogenesis, and targeted gene deletion experiments, the outlines of a working model for branching morphogenesis begin to emerge. Key branching morphogenetic molecules in this model include growth factors, transcription factors, distal effector molecules (such as extracellular matrix proteins, integrins, proteinases and their inhibitors), and genes regulating apoptosis and cell proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.physiol.62.1.595
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Experimental and Human Surveillance on BHC and DDT Insecticides Commonly Used in India (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 534 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb30159.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Serum hexachlorocyclohexane residues in workers engaged at a HCH manufacturing plant (1986)
    Springer
    International archives of occupational and environmental health 57 (1986), S. 315-320 
    Details
    ISSN: 1432-1246
    Keywords: Hexachlorocyclohexane ; Occupational exposure ; Biological monitoring ; Serum residues ; β-HCH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The accumulation of hexachlorocyclohexane, one of the most commonly used chlorinated insecticides, was studied in a high-risk group of people who are exposed during its manufacturing process. The serum HCH concentration was estimated by quantitating its α, β, γ and δ-isomers with the help of GLC analysis. Exposed workers involved in maintenance work were found to have 3 times higher HCH residues than the controls, while in the plant operators and supervisors the levels were 5 times higher. The most severely exposed were the handlers who are in direct contact with the insecticide. The level of serum HCH residues in them was found to be about 12 times higher than those in the controls. The percentage composition of the insecticide, with respect to the different isomers, varied up to 20% for the γ-isomer, up to 30% for α-isomer and had between 60%–100% of the β-isomer in the samples. The serum levels of the insecticides were clearly related to the workers' job-related close contact, intensity, frequency, and the duration of their exposure. The total of HCH residues in the sera studied were in the range of 0.143–1.152 ppm. The importance of these findings and the relevant protective measures are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406186
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Experimental studies on insecticides commonly used in India (1981)
    Springer
    Journal of cancer research and clinical oncology 99 (1981), S. 143-152 
    Details
    ISSN: 1432-1335
    Keywords: Hexachlorocyclohexane ; Mice ; Hepatocarcinogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using hexachlorocyclohexane (BHC) as a model histopathological, histoenzymological, biochemical, and electrophoretic studies were undertaken to find out certain parameters for early diagnosis of liver cancer. In addition, cytogenetic studies were carried out to evaluate the effect of BHC feeding on mitotic and meiotic divisions. The results of these investigations suggest that there is a significant change in liver weight in experimental group. Histologically, liver cells follow a definite sequential cellular alteration ultimately leading to liver tumor. Histochemically, well defined pattern of glycogen accumulation and iron distribution in hepatocytes was observe. The electron-microscopic observation demonstrated prominently the proliferation of agranular endoplasmic reticulum in early stages. The distribution of certain enzymes linked with plasma membrane, lysosomes, and mitochondria showed the functional alteration of these organelles both in neoplastic nodules and tumours induced by BHC. The biochemical changes observed in gluconeogenic enzymes (G6Pase and F1,6dipase) and dehydrogenases (LDH, ICDH, and MDH) at different duration of exposure to BHC indicated decrease in enzyme activity of both gluconeogenic pathway and tricarboxylic acid cycle, linked with energy metabolism. These changes tend to recover with discontinuation of BHC but 8 months continuous feeding produces irreversible changes in G6Pase activity. Using polyacrylamide gel electrophoresis technique a change in serum proteins and LDH isoenzymes was observed. However, extrapolation of these findings to human situation needs more extensive studies, taking into account all possible variables, such as the DDT and BHC load in our environment and the body burden resulting there from.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412450
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Effect of hexachlorocyclohexane on somatic and meiotic divisions in male Swiss mice (1981)
    Springer
    Bulletin of environmental contamination and toxicology 26 (1981), S. 508-512 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01622128
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Effect of cadmium chloride on cell division and chromosomes in Chinese Hamster Ovary cells (1986)
    Springer
    Bulletin of environmental contamination and toxicology 36 (1986), S. 342-349 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01623518
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Effect of hexachlorocyclohexane feeding on testicular tissue of pure inbred Swiss mice (1979)
    Springer
    Bulletin of environmental contamination and toxicology 23 (1979), S. 431-437 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01769983
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Clinical and biochemical investigations to evolve early diagnosis in workers involved in the manufacture of hexachlorocyclohexane (1993)
    Springer
    International archives of occupational and environmental health 65 (1993), S. S193 
    Details
    ISSN: 1432-1246
    Keywords: Biological monitoring ; β-HCH ; Hexachlorocyclohexane ; Occupational exposure ; Serum residues
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 365 individuals exposed to hexachlorocyclohexane (HCH) during its manufacture were studied and compared with 146 controls. These 502 cases were divided into five groups on the basis of serum total HCH levels. Exposure was mainly through skin. Results indicate that neurological symptoms reported were due to recent exposure to HCH and were related to the intensity of exposure. ECG abnormalities were seen in exposed cases. A significant positive correlation to liver related enzymes γ GT, LAP and Alp. P was observed. β -globulins significantly increased along with an increase in total HCH. Changes in IgM levels were similar as observed in IgA. Remarkably high concentration of HCH residues were found in the serum samples of all exposed workers. β-HCH contributed more than 80% of the total HCH built up. Presence of circulating immune complexes was also detected in representative samples. Further, repeated biological monitoring was advised to be carried out among such workers exposed to HCH, to evaluate signs of severe health impairment in them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381339
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Studies on the polymerization of methyl methacrylate using ylide as an initiator and degradative transfer agent (1986)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 141 (1986), S. 103-111 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Die mit α-Picolinium-p-chlorphenacylid initiierte Polymerisation von Methylmethacrylat in Tetrachlorkohlenstoff bei 30, 35 und 40°C und einer Dauer von vier Stunden wurde dilatometrisch untersucht. Die Reaktionsordnungen im Hinblick auf die Konzentration von Ylid und Methylmethacrylat liegen bei 0,22 ± 0,1 bzw. 1,0. Die gesamte Aktivierungsenergie und der mittlere Wert von kp2/kt beträgt 21 kJ · mol-1 bzw. 0,37 · 10-2.Die Ergebnisse wurden als radikalische Polymerisation mit einer initiatorabhängigen Übertragung und einem bimolekularen Abbruch erklärt.
    Notes: The polymerization of methyl methacrylate (MMA) initiated by α-picolinium-p-chlorophenacylide in CCl4 at 30, 35, and 40°C for four h was investigated dilatometrically. The orders of reaction with respect to the concentrations of ylide and MMA are 0.22 ± 0.01 and 1.0, respectively. The overall energy of activation and an average value of kp2/kt are 21.0 kJmol-1 and 0.37 ± 10-2, respectively. The results are explained in terms of radical mode of polymerization with initiator dependent transfer besides bimolecular termination.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1986.051410111
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Studies on β-picolinium-p-chlorophenacylide initiated copolymerization of methyl methacrylate with styrene (1987)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 149 (1987), S. 139-150 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Die alternierende Copolymerisation von Methylmethacrylat mit Styrol unter Verwendung von β-Picolinum-P-chlorphenacylid als Radikalinitiator bei 55, 60 und 65°C und einer Reaktionszeit von 3 h wurde kinetisch untersucht. Die Copolymerisationsgeschwindigkeit (Rp) ist proportional der Quadratwurzel der Initiatorkonzentration und weist auf einen bimolekularen Abbruch hin. Der durchschnittliche Polymerisationsgrad nimmt mit zunehmender Initiatorkonzentration ab. Die ermittelten Werte für kp2/kt und für die Aktivierungsenergie betragen 1,43 · 10-3 l mol-1 s-1 bzw. 87 kJ mol-1. Die NMR Spektroskopie wurde zur Bestimmung der Struktur, Zusammensetzung und Stereochemie der Copolymeren verwendet.
    Notes: The alternating copolymerization of methyl methacrylate (MMA) with styrene (S) using β-picolinium-p-chlorophenacylide (β-PCPY) as radical initiator at 55, 60, and 65°C for 3 h has been kinetically investigated. The copolymerization rate (Rp) is proportional to the square root of [β-PCPY] and indicates bimolecular termination. The average degree of polymerization decreases as [β-PCPY] increases. The values of kp2/kt and energy of activation have been evaluated as 1.43 · 10-3 l mol-1 s-1 and 87 kJ mol-1, respectively. The NMR spectroscopy has been used to determine the structure, composition, and stereochemistry of copolymers.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1987.051490111
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...