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  • 1
    Electronic Resource
    Electronic Resource
    The role of radiation therapy for stage IIIB non-small cell lung cancer: Impact of clinical nodal stage on survival (1996)
    Springer
    International journal of clinical oncology 1 (1996), S. 13-17 
    Details
    ISSN: 1437-7772
    Keywords: non-small cell lung cancer ; radiation therapy ; clinical nodal staging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background From 1976 through 1989, 46 patients with stage IIIB non-small cell lung cancer (NSCLC) without malignant effusion were treated with definitive radiation therapy (RT) at Gunma University Hospital. Methods All patients were treated with 10 MV x-rays using antero posterior parallel opposed fields. The total dose ranged from 60 Gy to 70 Gy (mean dose; 66 Gy) with once daily standard fractionation. Results The actuarial two and five-year survival rates of the entire group were 22% and 10% respectively with a median survival time (MST) of 10 months. The survival of 18 patients with stage NO-2 disease was significantly better than the 28 patients with stage N3 disease (MST 21 versus 9 months;P〈0.05). There were no significant differences in survival based on age and sex. However, there was a borderline difference in survival rates between patients with a performance status of 0–1 and those with a status of 2–3 (P=0.06). Three patients with squamous cell carcinoma were alive after 5 years and were without disease progression. No patients with non-squamous cell carcinoma were free of disease after 5 years. Conclusion These results provide support for the use of definitive RT to manage those patients with limited stage IIIB squamous cell carcinoma not extending to N3 stage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02347262
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  • 2
    Electronic Resource
    Electronic Resource
    Rapid rise in FDG uptake in an irradiated human tumour xenograft (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 435-438 
    Details
    ISSN: 1619-7089
    Keywords: Key words: 2-[18F]Fluoro-2-deoxy-d-glucose ; Glucose metabolism ; Human tumour ; Apoptosis ; Radiation therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. In order to investigate early changes in the glucose metabolism of irradiated tumours, tumour uptake of 2-[18F]fluoro-2-deoxy-d-glucose (18FDG) was studied in human tumour xenografts. Three human tumour lines [ependymoblastoma (NNE), small cell lung cancer (GLS), and glioblastoma (KYG)] showing different radiosensitivities and incidences of radiation-induced apoptosis were subcutaneously transplanted into nude mice, and were irradiated at a single dose of 10 Gy. Then 0.5 mCi of 18FDG was intravenously administered 1 h before sacrifice. The animals were sacrificed at 2, 4 and 6 h following irradiation, and 18FDG accumulation in the tumours was examined. Before irradiation, GLS and KYG tumours showed significantly higher rates of 18FDG accumulation compared with NNE tumours (P 〈0.004 and P 〈0.001, respectively). NNE (the most radiosensitive tumour with the highest incidence of radiation-induced apoptosis), however, displayed a 2.3-fold higher rate of 18FDG accumulation at 2 h following irradiation compared with a non-irradiated group (P 〈0.01), and thereafter showed a plateau up to 6 h. The accumulation did not increase significantly in the other tumours with lower radiosensitivity and much less radiation-induced apoptosis. The rapidity of the increase in 18FDG accumulation in the most radiosensitive tumour line, occurring as early as 2 h following irradiation, suggests that the increase was independent of recovery phenomena following radiation damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00881817
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Rapid rise in FDG uptake in an irradiated human tumour xenograft (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 435-438 
    Details
    ISSN: 1619-7089
    Keywords: 2-[18F]Fluoro-2-deoxy-d-glucose ; Glucose metabolism ; Human tumour ; Apoptosis ; Radiation therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to investigate early changes in the glucose metabolism of irradiated tumours, tumour uptake of 2-[18F]fluoro-2-deoxy-d-glucose (18FDG) was studied in human tumour xenografts. Three human tumour lines [ependymoblastoma (NNE), small cell lung cancer (GLS), and glioblastoma (KYG)] showing different radiosensitivities and incidences of radiation-induced apoptosis were subcutaneously transplanted into nude mice, and were irradiated at a single dose of 10 Gy. Then 0.5 mCi of18FDG was intravenously administered 1 h before sacrifice. The animals were sacrificed at 2, 4 and 6 h following irradiation, and18FDG accumulation in the tumours was examined. Before irradiation, GLS and KYG tumours showed significantly higher rates of18FDG accumulation compared with NNE tumours (P 〈0.004 andP 〈0.001, respectively). NNE (the most radiosensitive tumour with the highest incidence of radiation-induced apoptosis), however, displayed a 2.3-fold higher rate of18FDG accumulation at 2 h following irradiation compared with a non-irradiated group (P 〈0.01), and thereafter showed a plateau up to 6 h. The accumulation did not increase significantly in the other tumours with lower radiosensitivity and much less radiation-induced apoptosis. The rapidity of the increase in18FDG accumulation in the most radiosensitive tumour line, occurring as early as 2 h following irradiation, suggests that the increase was independent of recovery phenomena following radiation damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00881817
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Large dose fraction radiotherapy in the treatment of glioblastoma (1989)
    Springer
    Journal of neuro-oncology 7 (1989), S. 113-119 
    Details
    ISSN: 1573-7373
    Keywords: glioblastoma multiforme ; radiation therapy ; large dose fraction irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-four adults with glioblastoma multiforme (astrocytoma, grade 4) underwent postoperative large dose fraction radiotherapy (LDFR; 5 Gy twice weekly) with Linac X-rays. The outcome in this group was compared with that of 26 patients who received conventional fractionated radiotherapy (CFR; 2 Gy 5 times weekly). The time, dose, and fractionation (TDF) factor was about 100 in both groups. The survival rates following LDFR and CFR were, respectively, 63% vs 65% at 1 year; 36% vs 8% at 2 years; 17% vs 4% at 3 years; and 4% vs 0% at 5 years. Although the survival curve for LDFR was superior to that for CFR, the difference was not statistically significant. Autopsies of nine LDFR and 13 CFR patients showed no residual tumor in one case and no cases, respectively; small residual tumor in three cases in each group; extensive coagulation necrosis of the tumor and surrounding brain tissue in one LDFR and four CFR patients; tumor proliferation in three LDFR and four CFR cases; and mixed glioblastoma and fibrosarcoma in one LDFR and two CFR patients. These results suggest that maximum tumor removal followed by LDFR may offer a better prognosis for patients with glioblastoma than that offered by surgery plus CFR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00165095
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    Paper (German National Licenses)
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