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  • 1
    Electronic Resource
    Electronic Resource
    Early gastric cancer with widespread lymph node metastases; A case report (1984)
    Springer
    Surgery today 14 (1984), S. 143-145 
    Details
    ISSN: 1436-2813
    Keywords: early gastric cancer ; widespread lymph node metastases ; mustard gas poisoning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The resected stomach from a 58-year old male patient showed a 4.3×3.2 cm, depressed (II c) lesion in the body, histology of which revealed moderately differentiated tubular adenocarcinoma with invasion reaching the submucosa. Widespread metastases of lymph nodes including superior mesenteric and para-aortic ones were noted. The patient once worked in a mustard gas (Yperite) factory, and had chronic bronchitis. The exposure to this toxic substance was discussed in relation to the diffuse metastases of cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469806
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of oxygen tension on tumor colony formations assessed by human tumor clonogenic assay (1986)
    Springer
    Surgery today 16 (1986), S. 148-151 
    Details
    ISSN: 1436-2813
    Keywords: oxygen tension ; clonogenic assay ; tumor colony formation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To clarify the effects of oxygen tension on colony formation of fresh human tumor cells we examined 25 fresh human tumor samples (sixteen gastric cancers, three colon cancers three breast cancers, one esophageal cancer, one leiomyosarcoma and one malignant lymphoma), using the human tumor clonogenic assay (HTCA) technique. Three different oxygen tensions (2 per cent, 5 per cent, 20 per cent) were tested. At 5 per cent O2, which is considered to be physiological oxygen tension, 19 out of 26 tumors (13/16 in gastric cancer, 2/3 in colon cancer, 1/3 in breast cancer, 1/1 in esophageal cancer, and 1/1 in leiomyosarcoma) showed significant increases of plating efficiencies as compared to those at 20 per cent O2. On the other hand, decreases in plating efficiencies were observed at 2 per cent O2 in seven out of 12 tumors as compared to 20 per cent O2 and eight out of 12 tumors, as compared to 5 per cent O2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471086
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  • 3
    Electronic Resource
    Electronic Resource
    Prediction of individual tumor chemosensitivity in subrenal capsule assay (1986)
    Springer
    Surgery today 16 (1986), S. 257-261 
    Details
    ISSN: 1436-2813
    Keywords: subrenal capsule assay ; chemotherapeutic agents ; tumor sensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fifty-three tumor specimens, including thirty-one stomach and seven esophageal cancers, were examined to determine the individual tumor sensitivity to chemotherapeutic agents. Using the subrenal capsule assay (SRC assay), tumor specimens were implanted under the renal capsule of male, 8 week old ddY mice, after cutting the tissues into 1.5 mm cubed fragments. Following the implantations, chemotherapeutic agents were injected daily for 3 days and the relative variations of tumor weights were calculated. An 84.9 per cent of the total evaluability rate was obtained and implanted tumor specimens responsed to chemotherapeutic agents in 26.7 per cent. The correlation rate between tumor sensitivity in SRC assay and clinical responses was obtained in 72.9 per cent. The predictive accuracy rate of the clinical responses was 50.0 per cent, while 100 per cent of the prediction rate of clinical resistance was obtained. With regard to upper gastro-intestinal cancers, 83.9 per cent of the evaluability rate and 18.2 per cent of response rate in SRC assay were obtained. These results indicate that this assay is equivalent to other procedures for predicting individual tumor sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470934
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  • 4
    Electronic Resource
    Electronic Resource
    The acceptable delay between biopsy and radical mastectomy in breast cancer patients (1989)
    Springer
    Surgery today 19 (1989), S. 679-683 
    Details
    ISSN: 1436-2813
    Keywords: biopsy ; breast cancer ; radical mastectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects on the prognosis of breast cancer, of the delay between biopsy and radical mastectomy were studied in 394 patients. No delay had been experienced by 148 cases (no delay group), no biopsy had been performed in 166 cases (no biopsy group) and 80 cases had experienced a delay of 1 day or longer after having had a biopsy taken at a different institution (delay group). The recurrence rate of the no delay group was 10.8 per cent (16/148), whereas that of the delay group was 18.8 per cent (15/80). The relapse free survival rate of the no delay group was superior to that of the delay group (Kaplan Meier’s method: p〈0.05). The delay group was further divided into two groups according to the duration of delay, namely: a group whose delay was less than 7 days and another whose delay was longer than 8 days. There was no significant difference between the relapse free survival rates of the no delay group and the less than 7 days group, however, a significant difference was observed between the no delay group and the longer than 8 days delay group (p〈0.05). The acceptable delay between biopsy and radical mastectomy may therefore be concluded as less than 7 days.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471718
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  • 5
    Electronic Resource
    Electronic Resource
    Antitumor effects of recombinant human tumor necrosis factor against human tumor xenografts transplanted into nude mice (1987)
    Springer
    Surgery today 17 (1987), S. 51-54 
    Details
    ISSN: 1436-2813
    Keywords: human tumor xenograft ; nuce mouse ; recombinant human tumor necrosis factor (TNF)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Antitumor activities of recombinant human tumor necrosis factor (rH-TNF) against human tumor xenografts in nude mice were studied. Thirteen human tumor xenografts serially transplanted into nude mice were used for experiments; five gastric, two breast, two gallbladder, one colon and one esophageal carcinoma, one liposarcoma and one squamous carcinoma of the neck. They were inoculated into the subcutaneous tissue of BALB/c nu/nu nude mice and the treatment was started when the estimated tumor weight reached 100–300 mg. rH-TNF was administered intratumorally at schedule of qd×5 or q3d×5. rH-TNF showed a marked antitumor activity against various human tumors. The hemorrhagic necrosis was observed in all types of the human tumor xenografts (100 per cent), and the complete regression of the tumor was noted in 4 of 11 tumors (36.4 per cent). On the contray, intraperitoneal rH-TNF exhibited little antitumor effect. The additive effect in the combination of TNF and Mitomycin C was observed against two Mitomycin C resistant gastric tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470586
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  • 6
    Electronic Resource
    Electronic Resource
    Comparative study on nude mice isotope assay (NM-IA) and subrenal capsule assay (SRCA) sensitivity tests of anticancer agents (1987)
    Springer
    Surgery today 17 (1987), S. 99-103 
    Details
    ISSN: 1436-2813
    Keywords: chemosensitivity test ; nude mice isotope assay ; subrenal capsule assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A comparative study on nude mice isotope assay (NM-IA) and subrenal capsule assay (SRCA) was done to evaluate the usefulness ofin vivo assays for predicting individual tumor sensitivity against anticancer agents. Sixty-one fresh tumor specimens collected at surgery, under sterile conditions, were examined. Mitomycin C (MMC), 5-fluorouracil (5-FU), cyclophosphamide (CPM), adriamycin (ADM) and cis-DDPlatinum (CDDP) were used in both assays. In NM-IA, the tumor sensitivity was determined by the amount of3H-thymidine incorporated into the tumor which had been implanted into subcutaneous spaces of BALB/c nude mice. In the SRCA, the relative increase in weight of the tumor implanted into the subrenal capsular space of ddY mice was determined and measurements made to evaluate the chemosensitivity. Evaluability rates of the trials were 86.9 per cent with both assays and the response rates were 35.8 per cent in NM-IA and 34.0 per cent in SRCA, respectively. Against MMC, 5-FU, CPM, ADM and CDDP, overall consistency rates between the two assays were 77.8 per cent, 88.6 per cent, 72.7 per cent, 81.8 per cent and 68.2 per cent, respectively. In 8 of these 53 evaluated assays, correlations between the results of assays and clinical effects were examined and overall predictive accuracy rates were 87.5 per cent with both assays. Significant differences between these twoin vivo chemosensitivity tests were not evident.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470648
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  • 7
    Electronic Resource
    Electronic Resource
    Comparative studies onin vitro human tumor clonogenic assay (HTCA) andin vivo nude mouse-isotope assay (NM-IA) (1987)
    Springer
    Surgery today 17 (1987), S. 104-109 
    Details
    ISSN: 1436-2813
    Keywords: human tumor clonogenic assay ; nude mouse-isotope assay ; anticancer agent ; chemosensitivity test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Comparative studies between thein vitro human tumor clonogenic assay (HTCA) and nude mouse-isotope assay (NM-IA), in which the final evaluation was made with3H-thymidine incorporations of tumor cells transplanted into nude mice, were performed simultaneously on 60 fresh human tumors. Tissues used included 27 gastric cancers, 10 breast cancers, 7 colorectal cancers, 4 gallbladder cancers, 4 sarcomas, 3 lymphomas, and 5 other tumors. Mitomycin C (MMC), 5-fluorouracil (5-FU), cyclophosphamide (CPM) and adriamycin (ADM) were tested. The overall evaluable rate was 66.7 per cent in HTCA and 83.3 per cent in NM-IA, respectively. When the per cent survival in HTCA and the per cent inhibition in NM-IA less than 50 per cent was defined as drug sensitive, the drug sensitive rates of MMC, 5-FU, CPM, and ADM were 23.1, 16.7, 11.8, and 27.8 per cent in HTCA and 17.6, 18.4, 22.4, and 25.5 per cent in NM-IA, respectively. Although statistically significant correlations between the results of HTCA and those of NM-IA were obtained for MMC and ADM, no correlation was observed for 5-FU and CPM. The overall predictive accuracy rate of clinical response was 83.3 per cent (true positive rate 50 per cent and true negative rate 92.9 per cent) in HTCA and 76.0 per cent (true positive rate 37.5 per cent and true negative rate 93.8 per cent) in NM-IA, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470649
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  • 8
    Electronic Resource
    Electronic Resource
    Prospective randomized controlled study on bestatin in resectable gastric cancer —Third report— (1990)
    Springer
    Surgery today 20 (1990), S. 186-191 
    Details
    ISSN: 1436-2813
    Keywords: gastric cancer ; mitomycin C ; Tegafur ; Bestatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The efficacy of Bestatin as adjuvant immunochemotherapy for patients with resectable gastric cancer was investigated. Ninety-six patients with similar background factors were randomized into two groups; a control group and an experimental group, the patients in the experimental group receiving a daily oral dose of 60 mg Bestatin over a long period. All 96 patients were treated with a bolus intravenous injection of mitomycin C (MMC) plus oral administration of tegafur (FT-207, FT). The survival rate of the patients in the MMC+FT+Bestatin group was more favorable than that of the patients in the MMC+FT group, but the difference was not statistically significant. The survival rates of the MMC+FT+Bestatin group patients intthe stratification of stage III+IV and positive histological serosal invasion, ps(+), were significantly superior to those of the MMC+FT group patients (Logrank test: p〈0.05). Moreover, in patients with positive histological serosal invasion, the recurrence of peritoneal dissemination was significantly suppressed in the MMC+FT+Bestatin group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470767
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  • 9
    Electronic Resource
    Electronic Resource
    Prediction of the resistance of human tumors to adriamycin by chemosensitivity tests and DNA analysis of the multidrug resistance gene (1990)
    Springer
    Surgery today 20 (1990), S. 192-196 
    Details
    ISSN: 1436-2813
    Keywords: multidrug resistance ; gene amplification ; chemosensitivity test ; adriamycin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to predict natural resistance to Adriamycin (ADM), the amplification of multidrug resistance gene 1 (MDR1) was investigated in 50 human cancer specimens using Southern blot analysis. Genomic DNA was extracted from both human solid tumors and adjacent normal tissues for the analysis. MDR1 gene amplification was not observed in any of the patients tested, including 5 patients in whom ADM was not clinically effective. On the other hand, chemosensitivity tests performed on the tumor cells of these 5 patients indicated resistance to ADM. Our results therefore indicate that MDR1 gene amplification is rarely seen among clinical samples and that conventional chemosensitivity tests might be more useful for the prediction of ADM resistance in cancer patients than the analysis of MDR1 gene amplification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470768
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of oxygen tension on the antitumor activity of mitomycin C assayed by human tumor clonogenic assay (1987)
    Springer
    Surgery today 17 (1987), S. 402-406 
    Details
    ISSN: 1436-2813
    Keywords: mitomycin C ; human tumor clonogenic assay ; oxygen tension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of oxygen tensions on the antitumor activity of mitomycin-C (MMC) were surveyed using the human tumor clonogenic assay technique. Six human tumor xenografts (4 gastric cancers, and 2 colon cancers) were used in this study. Tumor cells were continuously exposed to MMC during the experimental period at various oxygen tensions, such as 2 per cent, which is considered to be hypoxic oxygen tension, 5 per cent which is considered as the physiological oxygen tension, and 20 per cent which is the conventionalin vitro culture condition. The antitumor activities of MMC on the 6 human tumor xenografts increased when the oxygen tension was lowered from 20 per cent to 5 per cent. However, no further increases of the antitumor activities of MMC were observed by lowering the oxygen tension from 5 to 2 per cent. Additionally, thein vitro antitumor activities of MMC at various oxygen tensions were compared with thein vivo chemosensitivities evaluated in nude mice. In five of the 6 human tumor xenografts,in vitro chemosensitivities assayed at 2 or 5 per cent oxygen tension were concordant within vivo chemosensitivities, althoughin vitro chemosensitivities assayed at 20 per cent were concordant within vivo chemosensitivities in 3 of the 6 tested tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470641
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