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  • 1
    Electronic Resource
    Electronic Resource
    Dynamic simulations of the interchange instability, ion production, and electron heating processes in an electron cyclotron resonance ion source plasma : The 8th international conference on ion sources (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 846-849 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Simulations hitherto performed with electron cyclotron resonance (ECR) ion sources (ECRIS) were mostly to predict physical quantities in their steady states. This article explores the time-dependent phenomena such as: interchange instability, ion production, and electron heating in order to simulate the time variations of hot-electron density, ion-trapping potential well, and core-electron temperature. This study has identified that the oscillations of around 1 Hz observable for these plasma parameters are a consequence of the interchange instability suffered by the hot electrons in the outer radial edge of an ECR shell. A pulsation of the ion-trapping potential well was found to take place under the unstable regime, thereby increasing the extractable ion current whenever the depth of the well is reduced due to the instability-triggered loss of electrons from the confinement. This finding may be exploited as a new method to obtain pulsed ion beams without pulsing the rf power. This article presents a formula for the best operating condition to achieve the highest steady ion beam currents out of an ECRIS. A self-consistent core-electron temperature was also predicted as a function of time. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1150309
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  • 2
    Electronic Resource
    Electronic Resource
    Large aperture, high-speed calorimeter for high-energy optical pulses (1985)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 56 (1985), S. 2253-2258 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A radiometric calorimeter is described in which the energy absorber works at the same time as a temperature sensor so that thermal equilibrium for the entire volume of absorber is not required before measuring an incident energy. The achievable frequency response is therefore quite high, and this is not offset by the size and/or damage threshold of energy receiver. The device, formerly called Rat's Nest Calorimeter (RNC), has been found quite useful for measuring the total energy of modern pulsed lasers with a large beam cross section. The aperture (presently 6 cm) can be increased arbitrarily without degrading the rise time. Excellent stability and high damage threshold ((very-much-greater-than)439 MW/cm2) result when a thick wire bolometer and amplifier combination is used. Response time (∼9 μs) and spectral flatness are much better than previously reported. Potentials of the RNC for measuring any energy which it absorbs up to 2 kJ at the rise time 60 ns (∼10 MHz) are discussed. The maximum sensitivity of the model 3.5 mJ/cm2 is sufficient to detect the radiative energy emitting from today's fusion test plasmas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1138359
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  • 3
    Electronic Resource
    Electronic Resource
    Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 92 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Systemic administration of pilocarpine preceded by lithium induces status epilepticus (SE) that results in neurodegeneration and may lead to the development of spontaneous recurrent seizures. We investigated the effect of Li/pilocarpine-induced SE on phosphorylation of the NMDA receptor in rat hippocampus. Phosphorylation of NR1 by PKC on Ser890 was decreased to 45% of control values immediately following 1 h of SE. During the first 3 h following the termination of SE, phosphorylation of Ser890 increased 4-fold before declining to control values by 24 h. Phosphorylation of NR1 by PKA was also depressed relative to controls immediately following SE and transiently increased above control values upon the termination of SE. SE was accompanied by a general increase in tyrosine phosphorylation of hippocampal proteins that lasted for several hours following the termination of seizures. Tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDAR increased 3–4-fold over control values during SE, continued to increase during the first hour following SE and then declined to control levels by 24 h. SE resulted in the activation of Src and Pyk2 associated with the postsynaptic apparatus, suggesting a role for these enzymes in the SE-induced increase in tyrosine phosphorylation. Changes in phosphorylation of the NMDA receptor may play a role in the pathophysiological consequences of SE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2005.02977.x
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  • 4
    Electronic Resource
    Electronic Resource
    Distinctive distribution of human papillomavirus type 16 and type 20 DNA in the tonsillar and the skin carcinomas of a patient with epidermodysplasia verruciformis (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Epidermodysplasia verruciformis (EV) is a rare skin disease characterized by disseminated pityriasis versicolor-like or flat wart-like lesions and by the development of skin carcinomas. It is well established that specific cutaneous human papillomaviruses (EV–HPVs) are associated with both benign and malignant skin lesions in EV patients. However, little is known of the relationship between HPV and the mucosal lesions of EV patients. Objectives To detect and identify HPV types associated with skin and mucosal lesions of an EV patient. Patient/methods We investigated the skin carcinoma and the coexisting tonsillar carcinoma of a 41-year-old man with EV. Histopathologically, both lesions were squamous cell carcinomas. We analysed these two lesions by immunohistochemistry, in situ hybridization, and by molecular virology. Results Neither skin nor tonsillar lesions exhibited positivity for HPV capsid antigen by immunohistochemistry. By Southern blot hybridization, however, the skin carcinoma harboured ‘EV-specific’ HPV20 DNA, while the tonsillar carcinoma harboured ‘genital’ HPV16 DNA. In addition, in situ hybridization localized the respective viral DNA in the corresponding lesion. Conclusions The results indicate that EV–HPV could be responsible for the development of the skin carcinoma, but not the mucosal carcinoma in this patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03834.x
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  • 5
    Electronic Resource
    Electronic Resource
    A case of galactosialidosis (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary  Galactosialidosis is a lysosomal storage disease associated with a combined deficiency of β-galactosidase and neuraminidase, caused by a defect of another lysosomal protein, the protective protein. Three subtypes are recognized: the early infantile form, the late infantile form and the juvenile/adult form. We saw a patient with galactosialidosis of the juvenile/adult form, a 51-year-old Japanese man with angiokeratomas on both elbows and knees, myoclonus, ataxia, mental retardation and macular cherry-red spots. An electron-microscopic study of a skin biopsy showed membrane-limited vacuoles in the cytoplasm of the endothelial cells, pericytes and fibroblasts. Assays of enzymatic activity in cultured fibroblasts showed a marked decrease in both β-galactosidase and neuraminidase (sialidase). The substance contained in the cytoplasmic vacuoles appears to be glycoproteins with sialic acid, which is a terminal glycosyl residue, because the cytoplasm of the endothelial cells of the vessels and pericytes are stained by the Limax flavus agglutinin, a lectin that binds specifically with sialic acid. This technology may be useful for easy investigation of the distribution of the accumulation of such substances in the central nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05488.x
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  • 6
    Electronic Resource
    Electronic Resource
    A case of febrile ulceronecrotic Mucha–Habermann disease requiring debridement of necrotic skin and epidermal autograft (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary We report a case of febrile ulceronecrotic Mucha–Habermann disease (FUMHD) in a 21-year-old man. This disease is a severe form of pityriasis lichenoides et varioliformis acuta (PLEVA) and is characterized by the sudden onset of diffuse ulcerations associated with high fever and systemic symptoms. It is sometimes lethal especially in elderly patients. In the present case, intense generalized maculopapular erythematous plaques with central necrosis developed progressively in association with a high fever. Initial treatment with systemic betamethasone had been unsuccessful and the skin lesions, which covered about 50% of the body surface, became severely ulcerated. Although the development of new lesions had ceased spontaneously, widespread ulceration of the skin remained. Debridement of the necrotic skin and skin grafting using cultured epidermal autografts and meshed allografts of cadaver skin led to prompt reepithelization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.05039.x
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  • 7
    Electronic Resource
    Electronic Resource
    Feeding on filter paper by larvae of the silkworm, Bombyx mori L.
    Amsterdam : Elsevier
    Journal of Insect Physiology 10 (1964), S. 425-430 
    Details
    ISSN: 0022-1910
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0022-1910(64)90066-6
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  • 8
    Electronic Resource
    Electronic Resource
    Numerical computations of Landau and collisional damping of plasma lines
    Amsterdam : Elsevier
    Journal of Quantitative Spectroscopy and Radiative Transfer 12 (1972), S. 989-999 
    Details
    ISSN: 0022-4073
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4073(72)90088-X
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  • 9
    Electronic Resource
    Electronic Resource
    Coulomb-collision corrected ion-acoustic line profiles
    Amsterdam : Elsevier
    Journal of Quantitative Spectroscopy and Radiative Transfer 12 (1972), S. 1319-1330 
    Details
    ISSN: 0022-4073
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4073(72)90188-4
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  • 10
    Electronic Resource
    Electronic Resource
    Use of a wrist activity monitor for the measurement of nocturnal scratching in patients with atopic dermatitis (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background The amount of nocturnal scratching can be an indirect correlate of itch in pruritic dermatoses. We have previously used an infrared video camera to measure nocturnal scratching in atopic dermatitis (AD). Although this is a reliable method of measuring nocturnal scratching, it is not suitable for routine monitoring in clinical use. Objectives To find a simplified way of monitoring itch. Methods We tried using a wrist activity monitor (ActiTrac®) for the measurement of nocturnal scratching in patients with AD. ActiTrac® is a wristwatch-shaped device that contains a piezoceramic sensor to measure and record limb movement over a pre-set time interval. The acceleration signal produced by motion of the hands is stored and downloaded into a personal computer. The average value of acceleration (AVA, 10−3 g min−1) was calculated and compared with total scratching time as a percentage of total recording time (TST%) measured with the use of an infrared video camera in 63 recordings of 21 patients with AD. For 261 recordings in 29 patients with AD, the AVA was measured and correlated with disease severity, and compared with the AVA of five non-itchy controls. Results There was a significant correlation between the AVA and TST% (r = 0·91, P 〈 0·001), and a regression equation of y = 0·44x − 2·5 was obtained. The AVA correlated well with the severity of AD and definitely differed from the results observed in normal controls. The AVA (mean ± SD) was 44·4 ± 19·1 for 115 recordings in patients with severe AD, 23·2 ± 10·9 for 89 recordings in patients with moderate AD, 8·9 ± 6·0 for 57 recordings in patients with mild AD and 4·1 ± 1·9 for 25 recordings in five normal controls. The units used here are arbitrary units min−1 with a range of 0–250, which corresponds to 0–75 × 10−6 g min−1. Conclusions A wrist activity monitor is able to measure nocturnal scratching. However, further methods of analysis should be sought to select scratching activity exclusively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04019.x
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