ISSN:
1365-4632
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Japan A 56-year-old Japanese woman suffered from chronic persistent hepatitis, which was HBeAg and hepatitis B virus (HBV) DNA positive. In October 1996, her hepatitis deteriorated and was associated with an increase in the HBeAg titer and HBV DNA concentration. The HBeAg titer and HBV DNA concentration were followed on a monthly basis as shown in 〈link href="#t1"〉Table 1. The serum aspartate transaminase (AST), alanine transaminase (ALT), and total bilirubin reached peaks of 1427 IU/L, 1363 IU/L (8–35), and 2.2 mg/dL (0.2–1.2), respectively. Five weeks later, the patient developed symmetric, well-demarcated, dark, annular, erythematous lesions on the lower and upper extremities and face. The trunk and mucosal surfaces were spared (〈link href="#f1"〉Fig. 1). We made the clinical diagnosis of erythema multiforme (EM). The eruption cleared spontaneously within 2 weeks. She had no history of a previous eruption, recurrent throat infections, herpes simplex, or drug exposure.〈tabular xml:id="t1"〉1〈title type="main"〉 Serologic data showing the exacerbation of hepatitis B virus infection 〈table frame="topbot"〉〈tgroup cols="4" align="left"〉〈colspec colnum="1" colname="col1"/〉〈colspec colnum="2" colname="col2" align="char" char="."/〉〈colspec colnum="3" colname="col3" align="char" char="."/〉〈colspec colnum="4" colname="col4" align="char" char="."/〉〈thead valign="bottom"〉〈row rowsep="1"〉 –10 weeks 〈link href="#t1n1"〉 –5 weeks –2 weeks 〈tbody valign="top"〉HBV DNA (pg/mL)32110043HBeAg (cut-off index)0.641.80.05HBeAb (inhibition, %)99.936.999.9〈note xml:id="t1n1"〉* Weeks before the appearance of skin eruptions.〈figure xml:id="f1"〉1〈mediaResource alt="image" href="urn:x-wiley:00119059:IJD633:IJD_633_f1"/〉Symmetric, well-demarcated, dark, annular, erythematous lesions on the lower extremities
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1365-4362.1999.00633.x
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