ISSN:
1432-2072
Keywords:
Intra-cerebral injection
;
Climbing behaviour
;
Nucleus accumbens
;
Neuroleptic agents
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Climbing behavior induced by peripherally administered apomorphine in the mouse was reduced by 0.25–10 μg bilateral intra-accumbens fluphenazine, (±) and (-) sulpiride and by serotonin, but not by (+)sulpiride, dl-propranolol, phentolamine, atropine or methysergide. A specific antagonism of climbing could not be shown when fluphenazine was injected into the striatum, hypothalamus, thalamus, reticular formation, frontal cortex or cerebellum, but was apparent when a large dose of fluphenazine was placed below (but not above) the accumbens nucleus. 6-Hydroxydopamine denervation of the nucleus accumbens did not alter the climbing antagonism afforded by fluphenazine, although sulpiride was three-fold more effective following denervation. The data indicates an accumbens involvement in the climbing phenomenon, that sulpiride more effectively antagonises climbing after accumbens denervation and that the presumed dopamine agonist-antagonist interaction in the accumbens, which controls climbing, may also involve serotonergic function. The studies emphasise the value of the intra-cerebral injection technique to an analysis of drug action in the mouse.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00431110
Permalink