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  • 1
    ISSN: 1436-2813
    Keywords: distant lymph node metastasis ; early gastric cancer ; proliferating cell nuclear antigen (PCNA)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Among 601 patients with early gastric cancer (EGC), the clinicopathological findings of 5 patients (invasion of the mucosal layer in 2 and of the submucosal layer in 3) with distant lymph node metastasis according to TNM classification (third-or fourth-tier lymph node metastasis according to the Japanese classification) were investigated. The proliferating-cell nuclear antigen (PCNA) expression of EGC was also examined immunohistologically. The sites of distant metastasis were the nodes at the root of the mesentery, in the hepatoduodenal ligament, and the paraaortic nodes, while the PCNA-positive rate of EGC with distant lymph node metastasis (35.4%) was significantly higher than that of EGC without lymph node metastasis (14.7%,P=0.01), it was similar to that of EGC with perigastric lymph node metastasis. The cumulative survival rate of the EGC patients with distant lymph node metastasis (5-year survival rate 20.0%) was significantly lower than that without lymph node metastasis (88.2%,P〈0.0001), first-tier lymph node metastasis (76.9%,P〈0.04), or second-tier lymph node metastasis (77.1%,P〈0.04). Thus, although the prognosis of EGC patients with distant lymph node metastasis was poor, a dissection of the distant lymph nodes should be performed when metastasis is suspected.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1436-2813
    Keywords: Key Words: preoperative examination ; gastric cancer ; elderly ; postoperative complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1436-2813
    Keywords: gastric cancer ; liver cirrhosis ; postoperative complications ; lymph node dissection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To clarify the therapeutic strategies for gastric cancer surgery in the presence of cirrhosis, 39 patients with gastric cancer accompanied by liver cirrhosis were reviewed. Severe postoperative complications developed in 10 patients (25.6%), and there were 4 (10.3%) hospital deaths, 1 (2.6%) of which occurred within 1 month. Although extended lymph node dissection of D2 or more was adopted for low-risk patients, 3 of 19 patients who underwent such extensive operations, most of which involved complete lymph node dissection in the hepatoduodenal ligament, died. Conversely, only 1 of 20 patients who underwent limited lymph node dissection of D1 or less died. Postoperative massive ascites developed in 6 patients, 3 of whom died. The cumulative 5-year survival rate following curative resection was 63.7% for patients with early gastric cancer, and 13.9% for those with advanced gastric cancer. The most frequent cause of death was cirrhosisrelated, such as hepatic failure or hepatoma. In conclusion, extensive lymph node dissection for patients with gastric cancer accompanied by cirrhosis carried a risk of postoperative fatal massive ascites as lymphorrhea. Thus, lymph node dissection in the hepatoduodenal ligament should be avoided, except in patients with evident metastases, and as a rule, aggressive surgery should not be performed in cirrhotic patients.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1436-2813
    Keywords: preoperative examination ; gastric cancer ; elderly ; postoperative complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The treatment strategies in patients with gastric cancer aged 80 years or older have not yet been well defined. We examined the incidence of postoperative complications and hospital mortality regarding the preoperative condition of such patients. A preoperative examination included evaluations of the cardiac, pulmonary, renal, and hepatic functions, the presence or absence of anemia, nutritional status, and blood sugar content. The incidence of postoperative complications and hospital mortality were then studied in relation to the number of preoperative abnormal parameters. The incidence of postoperative complications was 37.0%. The rate of hospital mortality was 11.1%. Among the patients with abnormalities in five or more items, the incidence of complications was 76.9% and the rate of hospital mortality was 23.1%. In the patients with an operative time of 4h or longer, the same incidence was 71.4%. Among the patients who underwent a curative resection, the 5-year survival rate was 92.3%. For elderly gastric cancer patients with abnormalities in five or more items during a preoperative examination and for those showing a poor level of daily life activity, a less invasive treatment modality should be planned. Patients with abnormalities of four or fewer items at a preoperative examination appear to be good candidates for curative resection.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1436-3305
    Keywords: Key words Scirrhous gastric carcinoma ; Transforming growth factor β ; Peritoneal dissemination ; Immunohistochemical study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Background. Alterations in the activity of transforming growth factor β (TGF-β) in humans have been implicated in fibrosis, immunosuppression, development of cancer, and other disorders. Scirrhous gastric carcinoma is characterized by cancer cells that infiltrate rapidly in the stroma with extensive growth of fibroblasts and fibrous tissue. Hence, the majority of studies examining the role of TGF-β in gastric carcinoma have focused on scirrhous carcinoma. Methods. We undertook a retrospective immunohistochemical study of gastric carcinoma in order to characterize TGF-β expression in malignant gastric lesions and to determine whether TGF-β expression was related to disease progression. Results. TGF-β expression in scirrhous gastric carcinomas was significantly higher than that in nonscirrhous gastric carcinomas. In patients with advanced gastric carcinoma with surgically curative resection, TGF-β expression was significantly higher in those patients who developed peritoneal recurrence after surgery than in those who did not develop such recurrence. Patients with TGF-β expression-positive tumors had significantly poorer survival than did those with TGF-β expression-negative tumors (P = 0.017). In addition, multivariate Cox proportional hazard model analysis showed that TGF-β immunohistochemical status was an independent prognostic factor (P = 0.0031). Conclusion. These data suggest that TGF-β may contribute, in part, to the variations in histogenesis and to the prevalence of peritoneal dissemination in gastric carcinoma.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1436-2813
    Keywords: Key Words: gallbladder carcinoma ; metastatic liver tumor ; intra-arterial infusion chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1349-9432
    Keywords: laser induced fluorescence ; imaging lidar ; plant/vegetation monitoring ; tree leaves ; chlorophyll
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Laser-induced fluorescence imaging lidar was developed for in vivo plant/vegetation monitoring. Fluorescences of poplar tree leaves growing naturally at a distance of 60 m from the lidar were successfully detected as two spectral images at wavelengths of 685 nm and 740 nm. By comparing chlorophyll concentration quantified with high performance liquid chromatography, it was confirmed that the intensity ratio of the two wavelengths was converted into the chlorophyll concentration inside the leaves. The intensity ratio of the images reflected the status of the poplar tree in the process of senescence so well that it was possible to assess the living status of the tree as a numerical value. The performance characteristics and the potential of the laser-induced fluorescence imaging lidar for monitoring the physiological activities of plants and vegetation are described.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Production of phospholipase D (PLD) by Streptoverticillium cinnamoneum immobilized within porous particles was investigated in repeated batch fermentation. The enzyme productivity in repeated batch fermentation was 2.2-fold that obtained in batch fermentation without immobilization, since many of the immobilized cells could be utilized as seed cells for each subsequent batch cycle.
    Type of Medium: Electronic Resource
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