ISSN:
1573-904X
Keywords:
temafloxacin
;
sarafloxacin
;
difloxacin
;
ciprofloxacin
;
norfloxacin
;
high-performance liquid chromatography
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The fluoroquinolones, temafloxacin, sarafloxacin, and difloxacin, are determined in the bulk drug substances and in a variety of dosage forms using high-performance liquid chromatography (HPLC). The HPLC system used is also applicable for ciprofloxacin and norfloxacin. The procedure uses UV detection at 280 nm, which provides a linear response of the subject compounds to at least 20 µg/ml. Assay precision (RSD) values were ±1.2% or better for the bulk drugs and ranged from ±0.42 to ±2.3% for suspension, capsule, and tablet formulations. Drug recoveries were quantitative from the dosage forms tested. Sensitivity of the subject compounds is approximately 50 ng/ml (2.5 ng on column).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015992511885
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