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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 81 (1969), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY.— Dyskeratosis is a feature of certain benign and malignant epithelial disorders. In Bowen's disease, dyskeratosis is characterized by central displacement, aggregation and condensation of tonofilaments within individual cells at all levels of the epidermis. This premature keratinization is primary and is similar to the benign dyskeratosis observed in keratosis follicularis. Centrally displaced dyskeratotic material was observed intermingled with the mitotic apparatus. Giant cells apparently resulted, since nuclear but not cytoplasmic division was seen. Dyskeratosis may also be secondary, through phagocytosis by one cell of partly or completely keratinized material from other cells. This may result in formation of a second distinct type of giant cell.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 2 (1975), S. 0 
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Apoptosis is a process found in many tissues by which devitalized cells are eliminated in an orderly manner. In skin, apoptosis occurs following sunburn, in Bowen's disease and in basal cell carcinoma. Scattered cells are observed in which the cytoplasm has become condensed and dyskeratotic. These dyskeratotic cells are phagocytized, either in toto or in fragments by surrounding keratinocytes. This process involves the condensation, fragmentation, phagocytosis and digestion of individually degenerated cells. The mass of a tissue is thus related to the balance between cell formation (mitosis) and cell destruction (apoptosis). In epidermal and other surface tissues, the rate of exfoliation must also be considered.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 1 (1974), S. 0 
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Characteristic cells have been demonstrated as being individually dispersed throughout the superficial epidermis 24 h after being exposed to ultraviolet light. These „sunburn cells” with cosinophilic cytoplasm and pyknotic nuclei observed by light microscopy are also observed to be dyskeratotic by using electron microscopy.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 83 (1970), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY.— Melanosomes are formed within melanocytes and transferred via dendrites to keratinocytes. In caucasoids, most melanosomes are aggregated in membrane-bound organelles (melanosome complexes). These aggregates have phagocytic capacity, stain positively with aryl sulphatase and acid phosphatase, contain melanosomes apparently undergoing degradation, and are lysosomes. In addition to melanosome complexes, individual melanosomes, both in melanocytes and keratinocytes, also exhibit lysosomal properties of phagocytosis and hydrolytic enzyme activity. In contrast, negro melanosomes are mostly singly dispersed and are rarely aggregated in complexes. Melanosome dispersal contributes to the darker colour and superior sunlight protection of negro skin. Degradation by lysosomal enzymes explains the limitation of melanin principally to the basal layer.In skin with severe solar degeneration, particularly in xeroderma pigmentosum, pigment production is often apparently adequate since hypertrophic melanocytes and dendrites are conspicuous. However, pigment transfer from melanocytes to keratinocytes does not occur normally. Some keratinocytes contain little melanin while others show an increase. Melanosomes within keratinocytes of actinically damaged skin tend to be concentrated within larger than normal complexes. Skin colour and sunlight protection appear to depend not only upon the rate of melanin formation but also upon distribution and rate of degradation.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 84 (1971), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 234 (1969), S. 15-24 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Large non-membrane-bound keratohyaline granules and small membrane-bound granules (keratinosomes, membrane-coating granules) abound in the superficial epidermis. Following injection, ferritin is seen in intercellular spaces, within invaginations of the plasma membrane and within the small granules. Phagocytosis of ferritin by small granules supports the concept that they evolve from the cell periphery and move to the cell interior rather than the reverse. Some small granules have a characteristic internal laminated structure, but the majority do not. Most small granules stain positively with periodic acid-silver methenamine for glycogen and mucopolysaccharide. Acid hydrolase activity is diffuse and not localized to small granules within the granular layer, but some granules in the upper spinous layer may stain positively. These variations in structural, histochemical and functional characteristics support the hypothesis that small granules of the superficial epidermis are a heterogenous group of organelles.
    Notes: Zusammenfassung Große, nicht membrangebundene (Keratohyalin) und kleine membrangebundene Granula (Keratinosomen, Membrane-Coating granules) sind in der oberflächlichen Epidermis reichlich vorhanden. Nach Injecktion kann Ferritin in den Zellzwischenräumen, sowohl innerhalb der Invaginationen der Plasmamembrane als auch innerhalb der kleinen Granula, beobachtet werden. Phagocytose des Ferritins bei den kleinen Granula unterstützt die Auffassung, daß sie in der Zellperipherie entstehen und dann in die Richtung des Zellinneren, aber nicht in die umgekehrte Richtung, wandern. Obwohl einige kleine Granula eine charakteristische laminäre Struktur haben, zeigen die meisten nicht diese Struktur. Die meisten kleinen Granula reagieren positiv auf Glykogen und Mucopolysaccharide mit Perjodsäure-Silber-Methenamin-Färbung. Die Aktivität saurer Hydrolasen ist diffus und nicht nur auf die kleinen Granula im Str. Granulosum beschränkt, obwohl auch einige Granula im oberen Str. Spinosum positiv reagieren. Die Variationen des strukturellen, histochemischen und funktionellen Charakters unterstützen die Vermutung, daß die kleinen Granula der oberflächlichen Epidermis aus einer heterogenen Gruppe von Organellen bestehen.
    Type of Medium: Electronic Resource
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