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  • 1
    Electronic Resource
    Electronic Resource
    Thyroid cancer in children: Report of three cases and a review of the Japanese literature (1997)
    Springer
    Surgery today 27 (1997), S. 961-965 
    Details
    ISSN: 1436-2813
    Keywords: thyroid cancer in children ; childhood thyroid cancer ; thyroid carcinoma ; fine-needle aspiration biopsy (FNAB)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We experienced three cases of thyroid cancer in children less than 15 years of age between 1982 and 1995. We herein present these three cases with a review of 141 reported cases of childhood thyroid cancer in Japan. Our patients were 6, 13, and 14 years old. The patients, all girls, were diagnosed as having thyroid cancer based on diagnostic imaging. One of them was also diagnosed by a fine-needle aspiration biopsy (FNAB). One of them underwent subtotal thyroidectomy, and the other two underwent lobectomy. Modified neck dissections were performed on all three. Pathologically, the tumors were all papillary carcinomas. Multiple lymph node metastases were present in all patients. However, the postoperative courses have been good, and there have been no signs of recurrence, 10, 8, and 2 years after their respective operations. In 144 reported cases of childhood thyroid cancer in Japan including ours, the youngest patient was a 2-year-old boy, and the female to male ratio was 2.1:1. FNAB was performed in 25 cases, and 23 (92%) of the tumors were diagnosed as malignant. Histologically, 76% were papillary carcinoma and 20% follicular carcinoma. At operation, lymph node metastases were found in 80% of the cases and lung metastases in 17%. For treatment, 88% of the patients received a more extensive operation than a lobectomy. Of the 144 patients, 8 died.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02388147
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  • 2
    Electronic Resource
    Electronic Resource
    Modified Heineke-Mikulicz pyloroplasty as an effective gastric drainage procedure (1977)
    Springer
    Surgery today 7 (1977), S. 165-169 
    Details
    ISSN: 1436-2813
    Keywords: pyloroplasty ; vagotomy ; erosive gastritis ; stress gastric ulcer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were prepared with modified Heineke-Mikulicz pyloroplasty with longitudinal seromuscular incision, centering at pyloric ring, separation of submucosal layer around the pylorus and addition of transverse closure. This procedure combined with vagotomy was applied to the rats with cortisone administration and obstructive jaundice or exposure to the restraint plus cold water stress. Pyloroplasty and vagotomy seemed to prevent the occurrence of the severe damage on gastric mucosa without any suture line leakage whereas. Control rats had often erosive gastritis or hemorrhage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469348
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  • 3
    Electronic Resource
    Electronic Resource
    Histochemical and electron microscopic study on steroid-induced ulcer in rat stomach (1971)
    Springer
    Surgery today 1 (1971), S. 173-185 
    Details
    ISSN: 1436-2813
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The superficial multiple ulcers were produced in the body mucosa of the stomach in male Wister rats with fasting and administration of 10 mg cortisone daily for 4 days. Two non-fasting groups of rats administered 10 mg cortisone for 10 days or 5 mg cortisone for 20 days served as controls. The following results were observed in the mucosa histochemically and electron microscopically: 1) atrophy of the gastric mucosa, a decrease in the number of PAS positive cells and a decline in PAS positive reaction. 2) delay in physiological regeneration observed by3H-thymidine autography. 3) ultrastructual changes such as chromatin condensation of nucleus, swelling, abnormal shape or destruction of mitochondria, and increase in lysosomes, myelin-like degeneration, focal cytoplasmic degeneration, and expansion of the Golgi complex. 4) a decline in electron density of secretory granules in the mucous cells and chief cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02468907
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  • 4
    Electronic Resource
    Electronic Resource
    The three-dimensional structure of motor endplates in different fiber types of rat intercostal muscle (1985)
    Springer
    Cell & tissue research 241 (1985), S. 465-472 
    Details
    ISSN: 1432-0878
    Keywords: Striated muscle ; Muscle fiber type ; Schwann cells ; Motor endplate ; Scanning electron microscopy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The three-dimensional organization of the motor end plates in the red, white and intermediate striated muscle fibers of the rat intercostal muscle was observed under a field-emission type scanning electron microscope after removal of connective tissue components by HCl hydrolysis. The motor endplate of the white fiber had terminal branches (or axon terminals), which were large, long and thin, and small but numerous nerve swellings (or terminal boutons). The motor endplate of the red fiber had terminal branches, which were small, short and thick, and had large but fewer nerve swellings. The motor endplate of the intermediate fiber was intermediate in size and structure between these two. In detached nerve-ending preparations, primary synaptic grooves with slit-like openings of the junctional folds appeared on the surface of the muscle fibers. The primary synaptic grooves were more developed in the white fiber than in the red fiber, and they were intermediate in the intermediate fiber. The numerical ratio of slit-like openings was 1∶1.8∶3.5 in the red, intermediate and white fiber, respectively. The Schwann cells and their processes were observed on the surface of the motor endplate, with the processes covering the upper orifices of the primary synaptic grooves and sealing the terminal branches. The number of Schwann cells was usually three in the white fiber, two in the intermediate fiber and one in the red fiber.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214564
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  • 5
    Electronic Resource
    Electronic Resource
    Scanning electron-microscopic studies on the three-dimensional structure of mitochondria in the mammalian red, white and intermediate muscle fibers (1985)
    Springer
    Cell & tissue research 241 (1985), S. 251-256 
    Details
    ISSN: 1432-0878
    Keywords: Red muscle fibers ; Muscle fiber types ; Mitochondria ; Three-dimensional structure ; Scanning electron microscopy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The three-dimensional structure and arrangement of mitochondria in the red, white and intermediate striated muscle fibers of the rat were examined under a field-emission type scanning electron microscope after removal of cytoplasmic matrices by means of the Osmium-DMSO-Osmium procedure. Beneath the sarcolemma, spherical or ovoid subsarcolemmal mitochondria show accumulations. The mitochondria are numerous and large in size in the red fibers, intermediate in the intermediate fibers, and few and small in the white fibers. Paired, slender I-band-limited mitochondria were located on both sides of the Z-line and partly embraced the myofibrils at the I-band level; they occurred in all three types of fibers. In the intermyofibrillar spaces, numerous mitochondria formed mitochondrial columns. These columns were classified into two types: 1) thick mitochondrial columns, formed by multiple mitochondria each with an intermyofibrillar space corresponding to one sarcomere in length, and 2) thin mitochondrial columns, established by single mitochondria corresponding to one sarcomere in length. In the red fibers mitochondrial columns were abundant and the ratio of the thick and thin columns was almost the same, while in the intermediate fibers most of the columns belonged to the thin type. The white fibers displayed rare, very thin columns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217168
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  • 6
    Electronic Resource
    Electronic Resource
    Scanning electron-microscopic study on the three-dimensional structure of motor endplates of the slow (tonic) muscle fibers in the frog, Rana n. nigromaculata (1988)
    Springer
    Cell & tissue research 252 (1988), S. 211-213 
    Details
    ISSN: 1432-0878
    Keywords: Skeletal muscle fibers ; Slow fibers ; Motor endplate ; Neuromuscular synapses, vertebrate ; Frog (Rana n. nigromaculata)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The three-dimensional organization of the motor endplates of the slow fibers of the rectus abdominis muscle in the Japanese meadow frog (Rana nigromaculata nigromaculata Hallowell) is visualized by use of a field-emission scanning electron microscope after removal of connective tissue components by HCl hydrolysis. Clusters of shallow oval depressions ∼1–3 μm in diameter are seen in the postsynaptic membrane at intervals of about 150 μm. On the surface of these depressions, a few low bulges of postsynaptic membrane are irregularly arranged. Terminal boutons, ∼1–3 μm in diameter, occur along the length of nerve branches and terminals and fit into the shallow oval depressions of the postsynaptic membrane. The Schwann cells covering the terminal branches exhibit a simpler organization than those in twitch fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00213844
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  • 7
    Electronic Resource
    Electronic Resource
    Scanning electron-microscopic studies on the three-dimensional structure of sarcoplasmic reticulum in the mammalian red, white and intermediate muscle fibers (1985)
    Springer
    Cell & tissue research 242 (1985), S. 461-467 
    Details
    ISSN: 1432-0878
    Keywords: Muscle cells ; Sarcoplasmic reticulum ; Three-dimensional structure ; Scanning electron microscopy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The three-dimensional structure of the sarcoplasmic reticulum (SR) in the red, white and intermediate striated muscle fibers of the extensor digitorum longus muscle of the rat was examined under a field-emission type scanning electron microscope after removal of cytoplasmic matrices by the osmium-DMSO-osmium procedure. In all three types of fibers, the terminal cisternae and transverse tubules form triads at the level of the A-I junction. Numerous slender sarcotubules, originating from the A-band side terminal cisternae, extend obliquely or longitudinally and form oval or irregular shaped networks of various sizes in front of the A-band, then become continuous with the tiny mesh (fenestrated collar) in front of the H-band. The A-and H-band SR appears as a single sheet of anastomotic tubules. Numerous sarcotubules, originating from the I-band side terminal cisternae, extend in threedimensional directions and form a multilayered network over the I-band and Z-line regions. At the I-band level, paired transversely oriented mitochondria partly embrace the myofibril. The I-band SR network is poorly developed in the narrow space between the paired mitochondria, but is well developed in places devoid of these mitochondria. The three-dimensional structure of the SR is basically the same in all three muscle fiber-types. However, the SR is sparse on the surface of mitochondria, so the mitochondria-rich red fiber has a much smaller total volume of SR than the mitochondria-poor white fiber. Moreover, the volume of SR of the intermediate fiber is intermediate between the two.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225410
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  • 8
    Electronic Resource
    Electronic Resource
    High resolution scanning electron-microscopic study on the three-dimensional structure of the sarcoplasmic reticulum in the slow (tonic) muscle fibers of the frog, Rana nigromaculata (1989)
    Springer
    Cell & tissue research 255 (1989), S. 669-672 
    Details
    ISSN: 1432-0878
    Keywords: Muscle, striated, skeletal ; Slow muscle fibers ; Muscle cells ; Sarcoplasmic reticulum ; Scanning electron microscopy ; Rana n. nigromaculata (Anura)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The three-dimensional structure of the sarcoplasmic reticulum (SR) in the slow (tonic) fibers of the reclus abdominis muscle of the Japanese meadow frog (Rana nigromaculata nigromaculata Hallowell) was examined by high resolution scanning electron microscopy, after removal of the cytoplasmic matrices by the osmium-DMSO-osmium procedure. The SR forms a repetitive network throughout these fibers. At the level of the Z-line, a slender transverse tubule (T-tubule) runs transversely to the longitudinal axis of the myofibril. Small, spherical or ovoid terminal cisternae couple laterally with the T-tubule at intervals of 0.4–1.0 μm, and form a “terminal cisterna-T-tubule complex” on whose surface tiny indentations are occasionally seen. Each terminal cisterna gives rise to a few sarcotubules that run in various directions, divide frequently and form circular or oval meshes of diverse sizes in front of the A- and I-bands. The sarcotubules usually form small meshes in the middle of the A-band, but occasionally fuse and form a poorly developed H-band (fenestrated) collar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218807
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  • 9
    Electronic Resource
    Electronic Resource
    High -resolution scanning electron-microscopic studies on the three-dimensional structure of mitochondria and sarcoplasmic reticulum in the different twitch muscle fibers of the frog (1987)
    Springer
    Cell & tissue research 250 (1987), S. 489-497 
    Details
    ISSN: 1432-0878
    Keywords: Muscle cells ; Mitochondria ; Sarcoplasmic reticulum ; Scanning electron microscopy ; Frog (Rana n. nigromaculata)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The three-dimensional structure of the mitochondria and sarcoplasmic reticulum (SR) in the three types of twitch fibers, i.e., the red, white and intermediate skeletal muscle fibers, of the vastus lateralis muscle of the Japanese meadow frog (Rana nigromaculata nigromaculata Hallowell) was examined by high resolution scanning electron microscopy, after removal of the cytoplasmic matrices. The small red fibers have numerous mitochondrial columns of large diameter, while the large white fibers have a small number of mitochondrial columns of small diameter. In the medium-size intermediate fibers, the number and diameter of the mitochondrial columns are intermediate between those of the red and white fibers. In all three types of fibers, the terminal cisternae and transverse tubules form triads at the level of each Z-line. The thick terminal cisternae continue into much thinner flat intermediate cisternae, through a transitional part where a row of tiny indentations can be observed. Numerous slender longitudinal tubules originating from the intermediate cisternae, extend longitudinally or obliquely and form elongated oval networks of various sizes in front of the A-band, then fuse to form the H-band collar (fenestrated collar) around the myofibrils. On the surface of the H-band collar, small fenestrations as well as tiny hollows are seen. The three-dimensional structure of SR is basically the same in all three muscle fiber-types. However, the SR is sparse on the surface of mitochondria, so the mitochondria-rich red fiber has a smaller total volume of SR than the mitochondria-poor white fiber. The volume of SR of the intermediate fiber is intermediate between other the two.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218939
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  • 10
    Electronic Resource
    Electronic Resource
    T cell cytotoxicity of autologous and allogeneic lymphocytes in a patient with Crohn's disease (1994)
    Springer
    Journal of gastroenterology 29 (1994), S. 415-422 
    Details
    ISSN: 1435-5922
    Keywords: Crohn's disease ; CTL ; MHC
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a 27-year-old male with Crohn's disease (CD) of the small and large intestine, whose peripheral blood lymphocytes (PBL) showed increased cell-mediated cytotoxicity (CTL). Autologous and allogeneic effector cells from PBL and intestinal lymph nodes (LN) were isolated on a Ficoll-Hypaque gradient. Colonic cells were prepared as the target and were incubated for 6 h with effector cells, after being labeled with Na2 51CrO4. The CTL activity [effector/ target (E/T) ratio, 100:1] of PBL for autologous targets was increased by 38% compared with that in normal subjects (〈10%), while that shown by LN was not increased (14%). The CTL activity of allogeneic PBL prepared from three of four other CD patients was also increased. Anti-major histocompatibility (MHC) class I and II and CD4 and CD8 monoclonal antibodies (50μg/ml) significantly inhibited CTL, activity. Complement-mediated depletion of CD2+ cells significantly reduced CTL activity. These results suggest that MHC-restricted CTL may play a role in mucosal damage in some patients with Crohn's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02361237
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