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  • 1
    Electronic Resource
    Electronic Resource
    Local Cerebral Glucose Utilization During Development and Aging of the Fischer-344 Rat (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 37 (1981), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Local cerebral glucose utilization was measured in brain regions of awake Fischer-344 rats. Measurements were taken in 15 regions of 1-month-old rats, and 19 regions of 3-, 12-, 24-, and 34-month-old rats. Between 1 and 3 months, glucose utilization tended to increase in all brain regions; statistically significant increases occurred in seven regions. Between the ages of 3 and 12 months, glucose utilization decreased significantly in 12 regions. The greatest reductions (25% or more) occurred in the striatum, inferior colliculus, and pons, but the hypothalamus and thalamus, nucleus accumbens, and septum showed no statistically significant change. Cerebral glucose utilization did not change between 12 and 24 months or between 24 and 34 months of age. The results demonstrate a rise in cerebral glucose utilization with development from 1 to 3 months, a decline between 3 and 12 months, and a constancy in the second and third years that does not reflect reported senescence-associated neurochemical and morphological cerebral changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1981.tb05311.x
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  • 2
    Electronic Resource
    Electronic Resource
    Osteoporosis — Is it the same all over the world? (1991)
    Springer
    Journal of bone and mineral metabolism 9 (1991), S. 77-77 
    Details
    ISSN: 1435-5604
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02375938
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Treatment of malignant tracheobronchial stenosis by Dacron mesh-covered Z-stents (1994)
    Springer
    CardioVascular & interventional radiology 17 (1994), S. 33-35 
    Details
    ISSN: 1432-086X
    Keywords: Metallic stent, stenosis ; Bronchus ; Dacron mesh ; Drug delivery system ; Lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Z-stents partially covered with an expandable Dacron mesh into which epinephrine and thrombin were infiltrated, were used to reopen both mainstem bronchi, stenosed by bronchogenic carcinoma and to deliver hemostatic agents to the lesion. On follow-up 4 and 6 weeks later, airway patency was retained, the tumor surface was compressed, and the glossy surface of the stent suggested that it was covered with mucosa. For treatment of airway stenosis due to cancer invasion, a stent covered with a Dacron mesh sheet is thought to be effective in compressing the tumor and preventing tumor ingrowth into the stent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01102069
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  • 4
    Electronic Resource
    Electronic Resource
    A Dedicated Z-Stent for Acquired Saber-Sheath Tracheobronchomalacia (1997)
    Springer
    CardioVascular & interventional radiology 20 (1997), S. 462-465 
    Details
    ISSN: 1432-086X
    Keywords: Key words: Tracheobronchomalacia—Saber-sheath—Stent, self-expandable, metallic—Stress and strain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The tracheobronchial lumen has a continuous horseshoe arch morphology. We formed Z-stents accordingly to support the weakened cartilagenous portions. With this type of stent we treated a patient with acquired saber-sheath type tracheobronchomalacia (TBM), Rayl's type II, Johnson's grade III, whose condition was aggravated even under positive end expiratory pressure (PEEP) therapy. The patient improved gradually. No immediate complication was observed. Bronchofiberscopic examination revealed that the tracheobronchial arcade was closely strut-braced and showed no expiratory collapse. Six months later, when the patient was intubated due to asthmatic attacks, tissue ingrowth through the stent was found and removed. There was no recurrence of TBM. The patient died 2 years later of pneumoconiosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002709900194
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  • 5
    Electronic Resource
    Electronic Resource
    Treatment of malignant tracheobronchial stenosis by Dacron mesh-covered Z-stents (1994)
    Springer
    CardioVascular & interventional radiology 17 (1994), S. 33-35 
    Details
    ISSN: 1432-086X
    Keywords: Metallic stent, stenosis ; Bronchus ; Dacron mesh ; Drug delivery system ; Lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Z-stents partially covered with an expandable Dacron mesh into which epinephrine and thrombin were infiltrated, were used to reopen both mainstem bronchi, stenosed by bronchogenic carcinoma and to deliver hemostatic agents to the lesion. On follow-up 4 and 6 weeks later, airway patency was retained, the tumor surface was compressed, and the glossy surface of the stent suggested that it was covered with mucosa. For treatment of airway stenosis due to cancer invasion, a stent covered with a Dacron mesh sheet is thought to be effective in compressing the tumor and preventing tumor ingrowth into the stent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197912
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  • 6
    Electronic Resource
    Electronic Resource
    Hypoxemia is a risk factor for bone mass loss (1999)
    Springer
    Journal of bone and mineral metabolism 17 (1999), S. 211-216 
    Details
    ISSN: 1435-5604
    Keywords: Key words: rat ; DXA ; bone mineral content ; hypoxia ; chronic respiratory failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Time-dependent changes of bone mass in ambulant chronic respiratory failure patients 60 or more years of age were compared between those on home oxygen therapy (HOT) and those still free of HOT (non-HOT). HOT (n = 31) showed initial PaO2 of slightly greater than 60 Torr and non-HOT (n = 32) had PaO2 moderately greater than 60 Torr (64.4 Torr vs 75.1 Torr). PaCO2 in HOT was significantly higher than that of non-HOT (44.8 Torr vs 40.0 Torr). There was no difference in pulmonary function test results. The whole bone mineral density (BMD) as adjusted by age and sex was significantly lower in the HOT group than that in the non-HOT. At endpoints of the follow-up period over 2 years or more, daily bone losses in the whole BMD, whole bone mineral content, and lumber BMD were significantly more accelerated in HOT compared with non-HOT. When the Wistar rats were pair-fed and their locomotion was limited, the animal group placed for 4 weeks under hypoxic air showed a reduction in BMD as compared with the control. We suggest that hypoxemia contributes to bone mass loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007740050087
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  • 7
    Electronic Resource
    Electronic Resource
    Areal bone mineral density and bone phosphatase activities in experimental diabetes mellitus (1996)
    Springer
    Journal of bone and mineral metabolism 14 (1996), S. 153-157 
    Details
    ISSN: 1435-5604
    Keywords: diabetes mellitus ; mouse ; areal bone mineral density ; bone phosphatase activities ; DXA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate the mechanisms of osteopenia in diabetes mellitus induced experimentally in mice, we measured the bone mineral content, expressed as the bone mineral density per surface area (areal BMD), by dual energy X-ray absorptiometry; and we assessed the alkaline (ALP) and acid phosphatase (ACP) activities of the calvarial tissues, which are assumed to represent the functional activities of osteoblasts and osteoclasts, respectively. We found that at 8 weeks after the onset of streptozotocin-induced diabetes mellitus the areal BMD values of the total body, femurs, calvariae, and lumbar vertebrae in the diabetic group were smaller than those in the control group. As compared with the control group, the ALP/ACP activity ratio of the calvariae in the diabetic group had a tendency to be reduced at 4 weeks of diabetes when the calvarial ABMD was not different between the two groups; it was definitely reduced at 8 weeks. These results suggest that an imbalance of osteoblast and osteoclast activity might be one of the mechanisms of osteopenia in the diabetic mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02239483
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of menatetrenone on the bone and calcium metabolism in osteoporosis: A double-blind placebo-controlled study (1998)
    Springer
    Journal of bone and mineral metabolism 16 (1998), S. 106-112 
    Details
    ISSN: 1435-5604
    Keywords: Key words: bone metabolism ; calcium ; menatetrenone ; osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Menatetrenone (2-methyl 1,3-tetraprenyl-1,4-naphtoquinone; vitamin K2) is a vitamin K homolog. To evaluate its efficacy on cortical bone mineral density and its safety, a 24-week double-blind placebo-controlled study was conducted by enrolling 80 osteoporotic patients. Patients were given either 90 mg/day of vitamin K2 (n = 39) or a placebo (n = 41). Bone density was assessed on the X-ray film of the right second metacarpal bone using the microdensitometric method. In the vitamin K2 group, bone density increased by 2.20% ± 2.48% from the baseline; in the placebo group, it decreased by −7.31% ± 3.65% (P = .037, K2 vs placebo). Urinary excretion of γ-carboxyglutamic acid (Gla) significantly increased from 72.61 ± 4.08 nmole/mg creatinine before treatment to 88.36 ± 5.35 in the 24th week after completion of the vitamin K2 treatment (P = .008). In the placebo group, there were no significant changes in urinary Gla excretion. In the 24th week of the treatment, the urinary calcium/creatinine ratio in the vitamin K2 group decreased from 0.137 ± 0.018 to 0.118 ± 0.016; in the placebo group, it increased from 0.153 ± 0.018 to 0.189 ± 0.029. As a result, the 24-week levels in the vitamin K2 and placebo groups became significantly different (P = .028). There were a few adverse effects attributable to vitamin K2. Our findings suggest that vitamin K2 at a dosage of 90 mg/day is effective in maintaining peripheral cortical bone density and is safe in treatment for osteoporosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007740050034
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  • 9
    Electronic Resource
    Electronic Resource
    Changes of serum calcitonin in stress load (2000)
    Springer
    Journal of bone and mineral metabolism 18 (2000), S. 22-26 
    Details
    ISSN: 1435-5604
    Keywords: Key words: DA rat, stress, calcitonin, calcium, sympathetic nerve system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Calcitonin, one of the calcium-regulating hormones, is known to have diverse biological effects including those on the gastrointestinal tract. In this organ, the hormone is reported to inhibit gastric acid secretion, gastric motility, and gastrin secretion and to stimulate release of somatostatin, thereby exerting antiulcer and antilesion effects on stress-induced as well as other types of experimental gastric ulcers or lesions. This fact prompted us to examine changes in serum calcitonin concentration during the development of stress-induced gastric lesions in rats. DA rats were constrained in a stress cage after a 24-h fast and then immersed in 24°C water to the level of the xiphoid process for 2 or 5 h. Serum calcitonin concentrations in stressed rats were significantly lower than those in control rats. To investigate the mechanism of the decline in serum calcitonin level under stress in these rats, we conducted a time-course study of serum calcitonin concentration and ionized calcium level during water-immersion stress, lasting 2 h, and during 4 h following release from the stress. Water immersion caused a remarkable decrease in serum calcitonin concentration as early as at 30 min. After release from stress, serum calcitonin concentration gradually recovered. The ionized calcium level in the blood did not change significantly throughout the experimental period. Furthermore, to examine if the sympathetic nerve system was involved in the stress-induced change of serum calcitonin concentration, α- and β-receptor antagonists were administered intraperitoneally before stress exposure. Administration of α-receptor antagonist at a low dose that did not have any effect on serum calcitonin concentration in a preliminary study, restored the decline of serum calcitonin level, whereas β-receptor antagonist did not. These results suggest that stress-provoked decrease of serum calcitonin concentration may be mediated not by a change of ionized calcium level but by alteration of sympathetic nerve activity (particularly via the α-receptor).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007740050005
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