ISSN:
1433-8580
Keywords:
Sepsis
;
Ketone body
;
Redox state
;
Energy state
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The concentrations of acetoacetate,β-hydroxybutyrate, and adenine nucleotides, and the mitochondrial phosphorylative activities, induced by cecal ligation and punctured in the liver of septic rats, were determined. The concentrations of glucose, free fatty acids (FFA), and free amino acids in arterial blood were also studied along with ketone body concentrations. Hepatic energy charge levels decreased from 0.84 to 0.77 at 12h after the induction of sepsis (P〈0.01) and to 0.60 at 18h (P〈0.001). Mitochondrial phosphorylative activity was enhanced at 6h (P〈0.001) and decreased at 18 h later. Ketone body concentrations in the liver and the arterial blood decreased concomitant with the decrease in hepatic energy charge. The mitochondrial redox state increased significantly at 12 and 18h after the induction of sepsis (P〈0.01) concomitant with a marked decrease in the concentrations of ketone bodies (P〈0.01). Blood glucose levels remained within normal limits except for a transient increase at 6h, but plasma FFA levels decreased (P〈0.01). The plasma concentrations of aromatic amino acids (P〈0.001), proline, and alanine (P〈0.05) increased slightly at 18h. It is suggested that the ketogenic capacity of the liver is inhibited during sepsis, but that the liver maintains gluconeogenesis at relatively normal levels until a more advanced stage of sepsis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01852379
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