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  • 1
    Electronic Resource
    Electronic Resource
    Follow-up study of combination treatment (TAE and PEIT) for unresectable hepatocellular carcinoma (1994)
    Springer
    Cancer chemotherapy and pharmacology 33 (1994), S. S119 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The subjects were 35 patients with unresectable hepatocellular carcinoma. The patients were divided into a transcatheter arterial embolization group (TAE group, 18 cases) and a combination therapy group receiving both TAE and percutaneous ethanol injection therapy (TAE+PEIT group, 17 cases). The 50% survival period was 21.1 months for the TAE group and 37.8 months for the TAE+PEIT group (P〈0.05). The longest survival period in the TAE group was 89 months. In the TAE+PEIT group, one patient has survived for 59 months. The actuarial 1-, 2-, and 3-year survival rates for the TAE group were 82%, 45%, and 22%, respectively. For the TAE+PEIT group the rates were 83%, 64%, and 64%, respectively. The TAE+PEIT group showed a significantly higher survival rate in the 895-to 1.074-day period as compared with the TAE groupP〈0.05). Overall, the survival rate tended to be higher in the TAE-PEIT group (P〈0.1). The therapeutic responses of tumors were measured by the maximal reduction rate within 6 months of TAE and PEIT. In the TAE group, a PR was seen in only four cases. In the TAE+PEIT group, CRs and PRs were achieved significantly more frequently than in the TAE group. When the patients were divided into a responder group (CR, PR, and MR) and a nonresponder group (NC and PD), survival was significantly longer in the responder group. The findings of the present study suggest that the combination therapy was useful for improving the survival of patients with unresectable hepatocellular carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686682
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  • 2
    Electronic Resource
    Electronic Resource
    Efficacy of combination treatment — (TAE with adriamycin and ethanol) — for hepatocellular carcinoma (1992)
    Springer
    Cancer chemotherapy and pharmacology 31 (1992), S. S30 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Among 44 patients with hepatocellular carcinoma (HCC), combination treatment with both transhepatic arterial embolization (TAE) and ethanol injection therapy (EIT) was performed in 10 patients. Only two had tumors measuring less than 3 cm in diameter. In all, eight patients had solitary tumors and two had multiple tumors. The tumor was classified as stage I in one patient, stage II in six subjects, stage III in two patients, and stage IV in one subject prior to TAE, but one stage II case was changed to stage III after laparotomy. The clinical stage was I in two patients, II in six subjects and III in two patients. Five patients with tumors of stages I and II achieved either a complete response (CR) or partial response (PR). However, three patients with tumors of stages III and IV showed progressive disease (PD). Thus, the response rate (CR+PR) was 50%. For tumor stages I and II, the 1-, 2-, and 3-year survival values were 100%, 100%, and 83%, respectively. For tumor stages III and IV, the 1- and 2-year survival values were 75% and 25%, respectively. Combination treatment of HCC appears to be efficacious for tumor stages I and II.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687101
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  • 3
    Electronic Resource
    Electronic Resource
    Outcome of localized hepatocellular carcinoma treated with segmental arterioportal chemoembolization (1992)
    Springer
    Cancer chemotherapy and pharmacology 31 (1992), S. S69 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary When lipiodol is injected into the hepatic artery at a dose exceeding a certain level, it flows into the portal vein. On the basis of this feature, an emulsion of Adriamycin with lipiodol was injected into a segmental or subsegmental artery such that it was delivered to the portal vein of the same segment, and the artery was then embolized with Gelfoam. This segmental arterioportal chemoembolization (cement therapy) was performed in 50 patients with localized hepatocellular carcinoma. A posttreatment CT scan showed that almost 100% of the lesions were occupied by lipiodol. The cumulative survival values determined for the 50 patients were very high: 83.4% after 1 year and 62.7% after 2 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687109
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  • 4
    Electronic Resource
    Electronic Resource
    Effective cases of transcatheter arterioportal chemoembolization with high-dose iodized oil for hepatocellular carcinoma (1994)
    Springer
    Cancer chemotherapy and pharmacology 33 (1994), S. S69 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract By administering an excessive amount of iodized oil via the hepatic artery, anticancer drugs in the iodized oil flow into the portal vein through the arterioportal communication. This phenomenon permits chemotherapy against extracapsular infiltration by a hepatocellular carcinoma (HCC) nourished by the portal blood flow. From May 1983 through July 1992, 240 cases of HCC underwent transcatheter arterioportal chemoembolization (TAPCE) with more than 5 ml of iodized oil (mean, 15 ml) in our hospital. In all, 32 patients survived for more than 3 years, and the factors favoring the efficacy of TAPCE therapy were investigated. Doxorubicin (mean, 46 mg) was given to 31 patients and 20 mg mitomycin C was given to 1 patient. The patients included one Stage 1 case, 13 Stage 2 cases, 17 Stage 3 cases, and one Stage 4 case. The mean tumor size was 5.0 cm, and portal invasion was suggested in 8 cases by angiography. The tumors were divided into 5 types: 13 cases of the single nodular type (SN), 7 cases of the single nodular type with proliferation (SN-P), 3 cases of the multinodular fused type (MN-F), 5 cases of the multinodular type (MN), and 4 cases of the massive type. A complication of liver dysfunction was detected in 14 cases, and half of them were Child's class C. In all, 7 patients underwent hepatectomy and 6 received percutaneous ethanol injection after TAPCE. The treated area of TAPCE was classified as segmental, lobar, or total. Segmental and lobar administration of TAPCE yielded statistically effective results, and their tumor response rate was 86%. All of the MN-F and massive types showed a good tumor response. The incidence of intrahepatic distant metastasis was higher in the localized TAPCE group than in the total TAPCE group. Segmental and lobar TAPCE should be applied for localized infiltrating HCCs, even in cases associated with liver cirrhosis, but these methods have a limited capacity to prevent distant intrahepatic metastasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686671
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  • 5
    Electronic Resource
    Electronic Resource
    Therapeutic effectiveness of segmental arterioportal chemoembolization via hepatic artery for localized hepatocellular carcinoma (1992)
    Springer
    European radiology 2 (1992), S. 413-420 
    Details
    ISSN: 1432-1084
    Keywords: Hepatocellular carcinoma ; Iodized oil ; Doxorubicin ; Arterial chemotherapeutic embolization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Segmental arterioportal chemoembolization via hepatic artery with overflow to the segmental portal vein was performed in 41 patients with hepatocellular carcinoma. Emulsion of doxorubicin (mean 37 mg) and two-to-three volume of iodized oil (mean 11 ml) was infused from a segmental artery of the liver until the segmental portal branches around the tumor were visualized fluoroscopically. By the iodized oil accumulation, the tumors were divided into five types: single nodular (SN); single nodular with proliferation (SN-P); multinodular fused (MN-F); multinodular (MN); and massive. Massive and MN types showed high incidence of local recurrence. However, SN-P and MN-F types showed a good tumor response and no local recurrence. In 32 unresected cases the overall response rate was 53%, the 1-year actuarial survival was 90% and 3-year survival was 43%. Six of nine operative specimens revealed complete necrosis of the tumor microscopically and three showed 90–95% necrosis. Thick fibrous capsules were found in all nine resected cases around the necrosis both of the tumor and of the non-cancerous parenchyma. This therapy was regarded as having a great capacity to kill the infiltrative portion of localized tumor and the thick capsule may be a peculiarity of this therapy which played a major role in guarding against regrowth of the tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00176346
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