ISSN:
1432-1335
Keywords:
Ethanol
;
Dimethylnitrosamine
;
Liver tumors
;
Kidney tumors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary To study the effect of chronic alcohol consumption on tumor development due to dimethylnitrosamine (DMN) administration, female Sprague-Dawley rats were pair-fed for 3 weeks a nutritionally adequate liquid diet containing either ethanol (36% of total calories) or isocalorically substituted carbohydrates as control diet. Thereafter, the animals were maintained on laboratory chow and tap water ad libitum for another 2 weeks and received 1.5 mg DMN i.p. per day for the first 5 days. This 5-week cycle was repeated three more times. Chronic treatment with an alcohol-containing diet was shown to significantly improve the mean survival time of DMN-treated rats compared with identically treated animals fed the control diet, but the total number of tumors observed under these experimental conditions and the target organ remained virtually unchanged.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00399898
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