ISSN:
1435-1803
Keywords:
ornithine decarboxylase
;
polyamines
;
developed tension
;
protein synthesis
;
heart
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The relationship between isometric contraction and myocardial ornithine decarboxylase (ODC; EC. 4.1.1.17) activity was studied in right ventricular papillary muscles isolated from rabbits. ODC specific activity and polyamine content were significantly increased in papillary muscles contracting isometrically 90 times per minute at the apex of the length-tension, relationship for 4 to 5 hours when compared with paired non-contracting muscles or isometrically contracting muscles stimulated at 30 times per min. The increase in ODC activity appeared to be due to new protein synthesis since cycloheximide blocked the increase in ODC activity without affecting isometric function. Thus, the present results suggest that increased contractile demands of the heart may stimulate the synthesis of myocardial ODC, increase ODC activity and polyamine content.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01907210
Permalink