ISSN:
1860-1499
Keywords:
Atypical meningioma
;
Anaplastic meningioma
;
Ultrastructure
;
Brain invasion
;
Recurrence
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract To clarify the cytologic features of atypical and anaplastic meningiomas, 11 tumors from 4 patients were examined by electron microscopy and compared to 10 classic meningiomas. Although all of the classic meningiomas had oval nuclei, many cytoplasmic organelles, typical regular interdigitation of cell processes, and many well-developed desmosomes with many intermediate filaments, atypical meningiomas showed irregularlyindented nuclei, poorly-developed interdigitation of irregular cell processes, and a decreased number of desmosomes. Anaplastic meningiomas were composed of immature cells with scant cytoplasm and poorly-developed cell processes. Mitoses were occasionally observed. The intercellular spaces were obvious, and immature desmosomes with small amounts of filaments were rarely found. A high recurrence rate and metastases can be predicted from the presence of loose contacts between tumor cells and frequent mitoses in atypical and anaplastic meningiomas.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02348028
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