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  • 1
    ISSN: 1530-0358
    Keywords: Ileoanal pouch ; Defunctionalized rectum ; manometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: Our aim was to determine manometric status and functional outcome of the ileoanal pouch procedure in a subset of patients with defunctionalized anal sphincters as a result of long-term fecal diversion. METHODS: The anal manometric profiles of 12 patients defunctionalized for one year or more were compared with 26 patients with nondefunctionalized anal sphincters. Functional data were obtained from the Lahey Clinic Ileoanal Pouch Registry. RESULTS: Preoperative manometric data revealed a mean resting pressure of 91.5 mmHg in the nondefunctionalized group vs.68.7 mmHg in the defunctionalized group; mean squeezing pressure was 171.7 mmHg (nondefunctionalized group) vs.102.3 mmHg (defunctionalized group); and squeezing pressure volume was 1,283,000 mmHg 3 (nondefunctionalized group)vs.585,000 mmHg 3 (defunctionalized group). Functionally both groups had a mean of 6.1 bowel movements in a 24-hour period and could defer defecation for a mean of 2 hours. Leakage occurred in 22 percent of the defunctionalized group and 17 percent of the nondefunctionalized group (P=0.35). CONCLUSION: Despite physiologic perturbations, the long-term, defunctionalized anal sphincter can adequately support a restorative procedure without regard to timing of pouch creation.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1530-0358
    Keywords: Biofeedback ; Fecal incontinence ; Nonrelaxing puborectalis ; Constipation ; Manometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract BACKGROUND: Successful biofeedback therapy has been reported in the treatment of fecal incontinence and constipation. It is uncertain which groups of incontinent patients benefit from biofeedback, and our impression has been that biofeedback is more successful for incontinence than for constipation. PURPOSE: This study was designed to review the results of biofeedback therapy at the Lahey Clinic. METHODS: Biofeedback was performed using an eightchannel, water-perfused manometry system. Patients saw anal canal pressures as a color bar graph on a computer screen. Assessment after biofeedback was by manometry and by telephone interview with an independent researcher. RESULTS: Fifteen patients (13 women and 2 men) with incontinence underwent a mean of three (range, 1–7) biofeedback sessions. The cause was obstetric (four patients), postsurgical (five patients), and idiopathic (six patients). Complete resolution of symptoms was reported in four patients, considerable improvement in four patients, and some improvement in three patients. Manometry showed a mean increase of 15.3 (range, −3–30) mmHg in resting pressure and 35.7 (range, 13–57) mmHg in squeezing pressure after biofeedback. A successful outcome could not be predicted on the basis of cause, severity of incontinence, or initial manometry. Twelve patients (10 women and 2 men) with constipation underwent a mean of three (range, 1–14) biofeedback sessions. Each had manometric evidence of paradoxic nonrelaxing external sphincter or puborectalis muscle confirmed by defography or electromyography. All patients could be taught to relax their sphincter in response to bearing down. Despite this, only one patient reported resolution of symptoms, three patients had reduced straining, and three patients had some gain in insight. CONCLUSIONS: Biofeedback helped 73 percent of patients with fecal incontinence, and its use should be considered regardless of the cause or severity of incontinence or of results on initial manometry. In contrast, biofeedback directed at correcting paradoxic external sphincter contraction has been disappointing.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1530-0358
    Keywords: Anus ; Sphincter ; Mamometry ; Fissure ; Pathophysiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: The pathophysiology of anal fissure remains poorly understood. This study examines manometric findings in patients with anal fissure with use of a computer-assisted system, which helps to standardize manometric performance as well as generating longitudinal and cross-sectional profiles of the anal canal. METHODS: Water-perfused, eight-channel, computer-assisted manometry was performed on 12 patients with chronic anal fissure and compared with 12 age-matched and sex-matched controls. RESULTS: Mean maximum average resting pressure (MARP) was 120.5 mmHg in patients and 82.6 mmHg in controls (P =0.0005). Pain was felt during manometry in six patients. In these patients, MARP was 123.2 mmHg, and, in the other six patients, MARP was 117.8 mmHg. Sphincter length was 4.72 cm, and the high pressure zone or that part of the sphincter with pressure more than 50 percent of MARP) was 2.78 cm in length. The high pressure zone/sphincter length ratio was 58 percent compared with 48 percent in controls. Longitudinal profile was bell shaped. Elevated pressures were not confined to the site of the fissure. Cross-sectional analysis showed higher anterior pressures in the distal sphincter. Utraslow waves were seen in as many as 91 percent of patients and 73 percent of controls. However, ultraslow wave amplitude was 31 mmHg in patients and 15 mmHg in controls (P =0.03). The rectoanal reflex was normal; overshoot was not seen. CONCLUSIONS: The primary abnormality in fissure is persistent hypertonia affecting the entire internal sphincter, unrelated to pain. Cross-sectional pressure profiles may explain the predilection of fissures to occur in the posterior midline; other factors must prevent chronic fissures from healing.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 24 (1968), S. 929-930 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Resumen En el cerebelo de rata recién nacida existen espacios extracelulares mayores que 1000 Å los cuales progresivamente se reducen hasta que en la tercera semana, como en el adulto, las celulas y fibras se hallan separadas por endiduras de 150–200 Å. Estas observaciones indican que el reducido espacio usualmente hallado en el adulto no es un artificio tecnico como ha sido sugerido por algunos autores.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 8 (1969), S. 311-320 
    ISSN: 1432-1106
    Keywords: Cerebellum ; Cell fractions ; Nervous tissue ; Cerebellum ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Subcellular particles from the cerebella of rats ranging in age from newborn to adult have been obtained and studied by electron microscopic procedures. The material was homogenized in sucrose and successive centrifugations yielded a heterogeneous “nuclear” pellet containing free nuclei and cell debris, and a microsomal-ribosomal fraction in which three zones were distinguished: (a) the top, consisting of microsomes; (b) the bottom, formed exclusively by ribosomes; and (c) the middle, by both constituents mixed together. The fraction was free of contamination by other particles. A third pellet obtained from the previous centrifugations was layered on a discontinuous Ficoll-sucrose gradient. After centrifugation it yielded six bands, named, from top to bottom, A-F. Fraction A contained uncontaminated myelin fragments. B was made up of synaptosomes and occasional free mitochondria. F was a fraction largely formed of intact mitochondria. Bands C, D and E located between B and F were mixtures of synaptosomes and free mitochondria. There were changes in the fractions related to the age of the animals. No fraction A was obtainable during the first ten postnatal days, the number of synaptic vesicles per synaptosome increased in fractions taken during the second week, and augmentation of mitochondrial cristae was noted during the first three weeks. The isolation of fractions of uniform myelin fragments, synaptosomes, mitochondria, and microsomes-ribosomes from the developing cerebellum extends the possibility of biochemical analysis at subcellular level during the histogenesis of this organ.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 127-139 
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: In the course of ultrastructural studies on the cerebellar cortex of young rats a cilium was found in some Purkinje cells. The shaft, which is 1800 to 2000 ÅR thick, has an internal portion inside the cell body and an external one projecting into the neuropile. The basal body is consistently located near the Golgi apparatus. Rootlets with periodic cross-striations (interperiod distance of 525 ÅR) are attached to the basal body. The size and characteristics of the Purkinje cell cilium and its constituent parts compare with similar structures in the cilia of other cell types of the cerebellar cortex. Whether all or only some of the Purkinje cells have a cilium has not yet been determined. Possible functional roles of these organoids are considered.
    Type of Medium: Electronic Resource
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