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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 117 (1983), S. 765-771 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Neurosurgical review 23 (2000), S. 90-93 
    ISSN: 1437-2320
    Keywords: Key words Brain check-up ; Cerebrovascular disease ; Signal intensity ; Sonic detection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A sonic analysis system was developed for the detection of cervical and intracranial vascular disease (CVD). In this study, sound signals detected through the patient’s forehead were analyzed using a short-time Fourier transformation method, and data were evaluated according to the intensity of spectra. A total of 49 patients with CVD and 34 control subjects were studied and classified into four grades according to the intensity of the spectra. The true positive rate was 83.7% in patients with CVD, and the true negative rate was 94.1% in the control group. The sensitivity and specificity of this analysis system were 83.7% and 5.9%, respectively. The true positive rates for cerebral stenosis/occlusion, cerebral aneurysm, and arteriovenous malformation/fistula were 85.7%, 73.7%, and 100%, respectively. The future goal is clinical application as a mass-screening test for brain disease. This system shows potential for this purpose, and further development will continue.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 139 (1997), S. 1152-1154 
    ISSN: 0942-0940
    Keywords: Cerebrospinal fluid ; D dimer ; delayed cerebral vasospasm ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fibrinolytic agents are administered to resolve subarachnoid clot, a major reservoir for spasmogen, to prevent delayed cerebral vasospasm (VS) in patients with subarachnoid haemorrhage (SAH). However, intracranial bleeding often occurs, which may be caused by over-activation of fibrinolysis in the cerebrospinal fluid (CSF) milieu. We measured the levels of D dimer in the CSF and blood of patients with SAH to analyse the correlation between fibrinolytic activity and VS. CSF and blood samples were obtained three times, and VS was identified by angiography. The levels of D dimer in the CSF were significantly higher than in the blood, but changes with time were inverse. Patients with VS showed significantly lower levels of D dimer in both CSF and blood in the initial stage compared to those without VS. These observations suggest that monitoring of fibrinolytic activity in the CSF to identify patients eligible for additional fibrinolytic treatment could reduce the risk of VS and iatrogenic intracranial bleeding.
    Type of Medium: Electronic Resource
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