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Delayed Administration Of Jtp-2942, A Novel Thyrotropin-Releasing Hormone Analogue, Improves Cerebral Blood Flow And Metabolism In Rat Postischaemic Brain (2001)

Katsumata, T ; Katayama, Y ; Yonemori, H ; [et al.]

Melbourne, Australia : Blackwell Science Pty

Clinical and experimental pharmacology and physiology 28 (2001), S. 0

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ISSN: 1440-1681

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: 1. The aim of the present study was to examine the central nervous system action of JTP-2942, a novel thyrotropin- releasing hormone (TRH) analogue, from the point of view of cerebral blood flow (CBF) and metabolism in the postischaemic brain.2. Left middle cerebral artery ischaemia was induced for 90 min followed by reperfusion.3. Animals were separated into four groups: (i) low-dose (0.003 mg/kg ) JTP-2942; (ii) high-dose (0.03 mg/kg) JTP-2942; (iii) cystidine diphosphate choline (500 mg/kg); and (iv) saline. The test drug or saline was administered intravenously 1 week after ischaemia.4. Local CBF and local cerebral glucose utilization were measured autoradiographically, adjacent sections were stained with haematoxylin-eosin and infarction size was measured.5. JTP-2942 ameliorated the reduction of local CBF and glucose utilization except in the ischaemic core. In particular, the higher dose (0.03 mg/kg) of JTP-2942 significantly increased local CBF and glucose utilization not only in peri-infarcted areas, but also in distal and contralateral areas.6. These results suggest that JTP-2942 treatment may be beneficial for improving cerebral circulation and metabolism in the postischaemic brain.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1440-1681.2001.03395.x

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Expression of fibronectin receptor (integrin) in the uterus of rats in relation to the estrous cycle (1991)

Nishida, T. ; Murakami, J. ; Otori, T.

Springer

Histochemistry and cell biology 96 (1991), S. 279-283

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ISSN: 1432-119X

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary The expression and localization of fibronectin receptor (integrin), fibronectin, laminin and collagen type IV in the endometrium of the rat uterus during each period of the estrous cycle were investigated by immunofluorescent microscopy. Fibronectin receptor was observed at the epithelial cells of the endometrium and at vascular endothelial cells. At proestrus, when epithelial cells actively migrate, fibronectin receptor was observed at the basal and lateral epithelial cell surfaces. During estrus, fibronectin receptor had begun to disappear, little fibronectin receptor was observed at metestrus or diestrus. No prominent changes in the localization of fibronectin (seen at the vascular endothelial cells and in the stroma) or of laminin and collagen type IV (seen at the muscles and at the basement membranes of the epithelial and vascular endothelial cells) were observed in relation to the estrous cycle. Thus, uterine epithelial cells, like epithelial cells of the healing cornea, increase their expression of fibronectin receptor during active migration, probably facilitating their attachment to stromal fibronectin. This fibronectin-fibronectin receptor mechanism may underlie epithelial repair, whether the defect results from physiological processes or from an insult.