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Signal transduction Molecular ticket to enter cells (2002)

Oved, Shlomo ; Yarden, Yosef

[s.l.] : Nature Publishing Group

Nature 416 (2002), S. 133-136

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] The cells that make up our bodies live in tight-knit communities and communicate with each other almost constantly. They often do so by using messenger molecules such as growth factors; when these molecules bind to receptors on the cell surface, they activate a plethora of cellular processes that ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/416133a

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Antisense expression of the calmodulin gene from Colletotrichum trifolii impairs prepenetration development (2000)

Warwar, Vitor ; Oved, Shlomo ; Dickman, Martin B.

Oxford, UK : Blackwell Publishing Ltd

FEMS microbiology letters 191 (2000), S. 0

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ISSN: 1574-6968

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology

Notes: Calmodulin is a ubiquitous highly conserved calcium binding protein involved in cell signalling. Previous studies in our laboratory suggested a role for calmodulin in prepenetration morphogenesis in Colletotrichum trifolii, the causal agent of alfalfa anthracnose. In this report, we describe the cloning, sequencing and partial characterization of the calmodulin gene from C. trifolii. The gene is present as a single copy in the genome of C. trifolii and its predicted amino acid sequence shows considerable homology to other fungal calmodulins. The gene is most highly expressed during conidial germination and appressorial development. Using a Neurospora crassa inducible promoter driving the calmodulin gene in antisense orientation, transformants were obtained with constitutive levels of antisense calmodulin expression. Upon induction, transformants did not develop appressoria and were not pathogenic on alfalfa plants.