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Androgen producing adrenocortical carcinoma (1978)

Valente, Marialuisa ; Pennelli, Natale ; Segato, Patricia ; [et al.]

Springer

Virchows Archiv 378 (1978), S. 91-103

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ISSN: 1432-2307

Keywords: Adrenal cortex hormones ; Endocrinology ; Microscopy, Electron ; Neoplasms ; Virilism

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Two cases of androgen secreting adrenocortical carcinoma have been described by light and electron microscopy. The histological and ultrastructural features of the tumour cells were similar to those of compact cells of zona reticularis and to those described in virilizing adenomas. They possess numerous mitochondria with lamellar and tubular cristae, abundant smooth endoplasmic reticulum, lipofuscin bodies and scanty lipid. Irregularly shaped, crenated mitochondria, with outpouchings of the outer limiting membrane have also been observed. The clusters of neoplastic cells were surrounded by basement membrane which demonstrated a focal discontinuity, probably reflecting malignancy of the tumours. Hyperplasia of smooth endoplasmic reticulum and the presence of outpouchings of the mitochondrial outer limiting membrane might be the morphological manifestation of endocrine activity of the tumours.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00432353

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Graffi Virus and Immunological Tolerance in Leukaemogenesis (1967)

CHIECO-BIANCHI, LUIGI ; FIORE-DONATI, LUCIANO ; TRIDENTE, GIUSEPPE ; [et al.]

[s.l.] : Nature Publishing Group

Nature 214 (1967), S. 1227-1228

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] To test whether the observed age-dependent differences in the incidence of leukaemia are related to variations in the immunological state of the inoculated animals, other groups of mice were treated as follows: in group 1, CCH mice were inoculated subcutaneously, at various ages between 1 and 37 ...