ISSN:
1573-2584
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Various labelled diagnostic materials (Hippuran, diethylene triamine-penta-acetate, human serum albumin) were simultaneously administered to individuals exhibiting normal and pathological renal function in order to investigate the renograms of these compounds, as mutual reference tracers, helping each other in their correct interpretation, and to follow the movement of these tracers between their compartments. Three different radionuclides (125I,131I,58Co) used as labels were also investigated concerning their separate measuring possibilities under in vivo and in vitro circumstances. Dual ratio adjustment was carried out according to tracers $$\frac{{Hippuran*}}{{HSA*}}$$ and sides $$\frac{{leftkidney}}{{rightkidney}}$$ . So we got “secondary quotients” the values of which remained nearly constant in normal cases during renography. The values of the quotient, however, changed in pathological conditions. In addition to the kidneys, simultaneous measurements of the isotope pairs were made over the cardiac and shoulder, regions to detect the concentration changes of the tracers. It was found that the normal direction of the gradual activity decrease in the tracers. It was found is: shoulder (representing mainly the extravascular, compartment) — blood — kidney; in pathological cases the most striking activity decrement can be observed in the blood. Both the activity differences found at the various measurement points in vivo and the differences of the ratios between the identical in vivo — in vitro data refer to deviations of the Hippuran and Co-DTPA pools.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02081696
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