ISSN:
1573-6822
Keywords:
cyclosporin A
;
mutagenicity
;
sister-chromatid exchange drug effects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract We analyzed the induction of sister chromatid exchange (SCE) by cyclosporin A (CsA) as a marker of genotoxic potential. In 30 patients undergoing renal transplantation, SCE induction was tested before the introduction of CsA and 3 months later. We found that SCE frequency increased significantly at the end of 3 months. To our knowledge, this is the first study demonstrating in vivo induction of SCE by CsA in humans. We conclude that CsA has a genotoxic potential on human lymphocytes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007594421458
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