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  • 1
    ISSN: 1523-5378
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: H. pylori is a causative agent of chronic gastritis. However, the pathogenic mechanism by which H. pylori induces chronic inflammation and epithelial injuries in the gastric and duodenal mucosa is not well known. Investigators have recently reported that some monoclonal antibodies against H. pylori cross-react with the gastric epithelial cells. So, there exists the possibility that the autoimmune mechanism may be involved in the pathogenesis of chronic gastritis caused by H. pylori. The purpose of his study is to investigate whether the antibodies against H. pylori react with human tissues or not, using a large panel of monoclonal antibodies.〈section xml:id="abs1-2"〉〈title type="main"〉Materials and Methods.Two hundred and fourteen monoclonal antibodies against H. pylori were produced. An immunohistochemical staining of human tissues, including H. pylori-infected gastric mucosa, was performed using the antibodies.〈section xml:id="abs1-3"〉〈title type="main"〉Results.Of 214 monoclonal antibodies, 71 antibodies reacted with H. pylori in the gastric mucosa. Of 71 antibodies, 25 antibodies also reacted with gastric epithelial cells, 11 antibodies reacted with ductal cells of the salivary gland, 11 antibodies reacted with renal tubular cells, and 8 antibodies reacted with duodenal epithelial cells. The antibodies which showed cross-reactivity with gastric epithelial cells included those against urease, flagella, lipopolysaccharide, and heat shock protein of H. pylori.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions.It is believed that the autoimmune reaction might be involved in the pathogenesis of chronic gastritis due to H. pylori infection, and that the autoimmune reaction induced by H. pylori infection might also be involved in the pathogenesis of various diseases in other organs.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 270-273 (Aug. 2004), p. 102-107 
    ISSN: 1013-9826
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 120 (Feb. 2007), p. 193-198 
    ISSN: 1662-9779
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Physik
    Notizen: Kori Unit 1, which is the oldest nuclear power plant (NPP) in Korea has been operatedsince 1978. In addition, 10 other NPPs have been operating more than 10 years. As the number ofaging plants rise, public concern over the safety of operating NPPs has increased. Periodic safetyreview (PSR) in addition to the existing safety assessments are proposed by IAEA as an effectiveway to verify that operating NPPs maintain the high level of safety. In this regard, the Ministry ofScience and Technology (MOST), Korea’s nuclear regulatory body, recently established aninstitutional process through revision to the atomic energy act to introduce PSR. This PSR considers,among other factors, improvements in safety standards and practices, the cumulative effects of plantaging, operating experience, and the evolution of science and technology. In particular, theassessment and management of plant aging is one of the major areas. It includes identification ofthe system, structure and components (SSCs) for aging management, assessment of aging effectsand planning of aging management implementation program. PSR results could be one of theprocedural requirements that are utilized to renew an operating license of a NPP. This paperdescribes safety assessment requirements including PSR and aging management activities in Korea.This paper also includes the strategy and method for the application of PSR results to the agingmanagement and continued operation of NPPs
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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