ISSN:
0935-6304
Keywords:
Denaturants
;
Bitrex
;
Dithyl phthalate
;
APCI-MS
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The recently developed tandem technique, mass spectroscopy with atmospheric-pressure chemical ionization (APCI-MS) coupled with direct flow injection, was applied to the determination of Bitrex (denatonium benzoate) and diethyl phthalate in ethanol. The compounds were indentified from their total-ion chromatograms(m/z 50-500) and, simultancously, quantified using selected-ion chromatograms recorded at m/z 223 for diethyl phthalate and m/z 325 for Bitrex. Operating conditions were optimized for soft ionization (positive ion-mode) with fragmentation limited to that necessary for analyte identification, which was by the external-standard method. Calibration curves were rectilinear in the concentration rages 2-30 μg ml-1 (Bitrex) and 0.075-1.2% v/v (diethyl phthalate); measurement precision (RSDs were 11.48% for Bitrex and 2.22% for diethyl phthalate), and detection limits (0.017 μg ml-1 and 0.010% v/v, respectively) were adequate for simiultaneous quantitation and with high sensitivity. The lack of any sample pretreatment and the use of flow-injection analysis meant that the procedure was moere straightforward and rapid than previously reported methods.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240200605
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