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  • 1
    Electronic Resource
    Electronic Resource
    Effects of chronic sodium salicylate feeding on the impaired glucagon and epinephrine responses to insulin-induced hypoglycaemia in streptozotocin diabetic rats (1989)
    Springer
    Diabetologia 32 (1989), S. 61-66 
    Details
    ISSN: 1432-0428
    Keywords: Prostaglandins ; diabetes ; glucagon ; epinephrine ; hypoglycaemia ; sodium salicylate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The potential role of endogenous prostaglandins in glucagon and epinephrine responses to insulin-induced hypoglycaemia was studied in streptozotocin-diabetic and age-matched control adult male rats. Rats made diabetic with a single intravenous injection of streptozotocin (65 mg/kg) developed impaired glucagon and epinephrine responses to insulin-induced hypoglycaemia by 80–100 days. Plasma glucagon levels in response to insulin-induced hypoglycaemia in streptozotocin-diabetic rats (167+67 pg/ml) were significantly lower (p〈0.01) than those in control rats (929±272 pg/ml). Similarly, plasma epinephrine levels in hypoglycaemic state in streptozotocin-diabetic rats (l1±8 pmol/ml) were also significantly lower (p〈0.01) compared to control rats (37±13 pmol/ml). Steptozotocin-diabetic rats provided with sodium salicylate (25 mg/100 ml) in their drinking water from day one of diabetes exhibited prevention of the blunted glucagon and epinephrine responses to insulin-induced hypoglycaemia. About 80–100 days after the chronic sodium salicylate treatment in streptozotocin-diabetic rats, both plasma glucagon levels (1080±169 pg/ml) and plasma epinephrine levels (39±8 pmol/ml) were essentially identical to plasma glucagon levels (1074±134 pg/ml) and plasma epinephrine levels (37±5 pmol/ml) in control rats in hypoglycaemic state. These animals also exhibited an improvement in the diabetic state in that they had less severe hyperglycaemia and lack of weight gain. These results suggest that the blunted glucagon and epinephrine responses to insulin-induced hypoglycaemia may be related to altered prostaglandin levels in streptozotocin-diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265406
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ethanol influence on insulin secretion from isolated rat islets (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 58-60 
    Details
    ISSN: 1420-9071
    Keywords: Insulin ; islets ; ethanol ; adrenergic receptors ; cyclic AMP ; theophylline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary This study was done to delineate the role of α- and β-adrenergic receptors and cyclic AMP in the mechanism of ethanol effects on insulin release from isolated islets. Rats were given an α-adrenergic blocker, phentolamine, or a β-adrenergic blocker, propranolol. In addition, ethanol 1 g/kg was given intragastrically 1 h prior to sacrifice. Glucose mediated insulin release from isolated islets was enhanced by phentolamine and decreased by propranolol. Ethanol treatment inhibited glucose-induced insulin release from isolated islets of control rats as well as those given phentolamine and/or propranolol. Insulin release from isolated islets in response to dibutyryl-cyclic AMP was attenuated by ethanol. Theophylline enhanced glucose mediated insulin release from control islets but ethanol treatment produced a significant inhibition of insulin response. The data suggest that the site of action of the deleterious effects of ethanol on insulin release from isolated islets in rat does not involve adrenergic system and cyclic AMP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01975895
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Thermal emission of pions in antiproton-proton annihilation at 12 GeV/c (1981)
    Springer
    The European physical journal 7 (1981), S. 235-239 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using data of $$\bar pp$$ annihilation at 12 GeV/c we have found that centrally-emitted pions follow a thermal energy spectrum with an inclusive temperature of 111±2 MeV, the same as has been found for pions produced in πp collisions at 16 GeV/c. An analysis of individual high-multiplicity events to search for fluctuations in the temperature parameter on an event-byevent basis has been made, using two different methods. We obtained the value 0.18±0.02 for the relative dispersion of the temperature fluctuations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01436312
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    Paper (German National Licenses)
    Fulltext
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