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  • 1
    Electronic Resource
    Electronic Resource
    Sirenomelia: the mermaid syndrome (1996)
    Springer
    Pediatric surgery international 11 (1996), S. 580-581 
    Details
    ISSN: 1437-9813
    Keywords: Caudal regression syndrome ; Mermaid syndrome ; Sirenomelia ; Vascular steal theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sirenomelia, or mermaid syndrome, is the extreme form of caudal regression syndrome. We present another case of this fascinating anomaly with fused lower limbs, absent external genitalia, and absent genitourinary system. The patient could not be salvaged because of bilateral renal agenesis. Detailed autopsy findings and a review of the literature are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00626073
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  • 2
    Electronic Resource
    Electronic Resource
    Heterocyclic methacrylate-based drug release polymer system (1994)
    Springer
    Journal of materials science 5 (1994), S. 338-339 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: A heterocyclic methacrylate polymer system, developed originally as a low shrinkage polymer system, has been investigated as a drug release polymer and as a biomaterial for encouraging bone or cartilage regeneration. The system is based on poly (ethyl methacrylate) polymer powder mixed with tetrahydrofurfuryl methacrylate monomer and polymerized at room temperature (PEM/THFM). Promising results have been obtained with this biomaterial, and hence its water uptake properties were investigated in detall, in order to throw some light on the release processes that are involved in vivo and in vitro. Water soluble large molecule analogues were incorporated into the system; these additives increased the water uptake of the system. Isobornyl methacrylate was used as a diluent for the monomer to further reduce the water uptake of the system. In all cases the uptake kinetics did not obey simple diffusion theory, the process being very prolonged and complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00058958
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  • 3
    Electronic Resource
    Electronic Resource
    Water sorption behaviour of polymeric systems based on tetrahydrofurfuryl methacrylate (1999)
    Springer
    Journal of materials science 10 (1999), S. 147-151 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Earlier research has described the water absorption behaviour, drug release and biological properties of a room temperature polymerizing system based on poly(ethyl methacrylate) (PEM) powder and tetrahydrofurfuryl methacrylate (THFM) monomer. This work has been extended, with respect to water sorption behaviour, by replacing the monomer to various extents with hydroxyethyl methacrylate (HEMA), and poly(ethyl methacrylate) by ethyl methacrylate (EM)-THFM copolymers. Replacing the THFM with HEMA, and gelling with PEM, increased the diffusion coefficient progressively. The replacement of PEM by EM-THFM copolymers, when gelled with THFM monomer, substantially reduced equilibrium water uptake, and increased diffusion coefficients. However, with HEMA monomer, equilibrium uptake was unaffected, but the diffusion coefficient decreased with increasing THFM content of the copolymer. This is due to a complex interaction of THFM cross-linking the copolymer, and the effect of EM on the water uptake. Heat polymerizing the PEM-THFM system reduced equilibrium uptake and the diffusion coefficient, compared with the room temperature polymerizing system; this could reflect molecular weight differences. © 1999 Kluwer Academic Publishers
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008981322735
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  • 4
    Electronic Resource
    Electronic Resource
    The regeneration of articular cartilage using a new polymer system (1994)
    Springer
    Journal of materials science 5 (1994), S. 88-95 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: A polymer system based on room temperature polymerising poly (ethylmethacrylate) polymer powder and tetrahydrofurfuryl monomer has been investigated as a biomaterial for encouraging articular cartilage repair. This heterocyclic methacrylate polymer system swells slightly in situ and thus provides a good interface with subchondral bone resulting in mechanical stability with favourable uptake kinetics. Another feature of this polymer system is that it exhibits high water uptake which leads to absorption of the surrounding tissue fluid and matrix proteins, including growth factors; this may encourage the formation of new cartilage. Three weeks after implantation the tissue overgrowth contained cartilage components: chondrocytes, collagen type II, chondroitin 4-sulphate and chondroitin 6-sulphate. In addition numerous chondrocyte clones were observed at the edge of the defect and in the newly repaired tissue. By six weeks a superficial articulating surface was continuous with the normal articular cartilage with underlying tissue which showed some evidence of endochondral ossification. By nine weeks the surface covering of new cartilage had a widened and an irregular zone of calcified cartilage with thickened subchondral bone was present. At eight months the resurfaced cartilage remained intact above a remodelled subchondral bone end plate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00121696
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  • 5
    Electronic Resource
    Electronic Resource
    Heterocyclic methacrylates for clinical applications–further studies of water sorption (1997)
    Springer
    Journal of materials science 8 (1997), S. 667-674 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The room temperature polymerizing system comprising poly(ethyl methacrylate)-tetra hydrofurfuryl methacrylate (PEM/THFMA) has potential in orthopaedic and dental applications, and earlier work has shown it to have unusual water absorption characteristics. This aspect has been studied in further detail, by studying the water absorption behaviour from some biological solutions, and the effect of the addition of an antibiotic (gentamicin). For comparison purposes, a parallel system whereby tetrahydrofuryl methacrylate was replaced by hydroxyethyl methacrylate (PEM/HEMA), was studied. In the case of PEM/THFMA, water uptake was substantially reduced when absorption was carried out from solutions (from about 30% in water to about 1.5% in solutions of higher concentrations), and the corresponding diffusion coefficient increased (by a factor of several hundred). The addition of gentamicin increased uptake, but the extent of increase also decreased in solutions. It was concluded that uptake was related to the osmolarity of the external solution, and also on the presence of osmotic sites within the polymer; hence the uptake process appears to be governed by chemical potential considerations. At the higher uptakes, there was evidence of water clusters. In marked contrast, the uptake by the PEM/HEMA system was independent of the osmolarity of the external solutions, presumably due to the hydrophilic nature of HEMA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018531722265
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  • 6
    Electronic Resource
    Electronic Resource
    Evaluation of five commercial systems for identification of coagulase-negative staphylococci to species level (1989)
    Springer
    European journal of clinical microbiology & infectious diseases 8 (1989), S. 1001-1003 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Five commercially available systems for identification of coagulase-negative staphylococci to the species level were evaluated using 163 clinical staphylococcal isolates. The conventional method of Kloos and Schleifer served as reference method. The API 20GP system showed the highest rate of agreement with the reference method, correctly identifying 98.8% of the isolates. The Microscan system had an overall rate of agreement of 96.3 %, and Staph-Trac, Sceptor and Staph-Ident rates of 88.8 %, 87.6 % and 84. % respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967575
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