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  • 1
    Electronic Resource
    Electronic Resource
    Sex steroids and their receptors in patients with tumors of the pancreas (1998)
    Springer
    Bulletin of experimental biology and medicine 126 (1998), S. 816-819 
    Details
    ISSN: 1573-8221
    Keywords: pancreatic cancer ; hormones ; receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A tendency toward an increase in serum content of sex steroid-binding globulin and a decrease in the total concentration of testosterone and its free and globulin-bound fractions and in the index of free androgens was observed in patients with pancreatic cancer. There were no statistically significant differences in baseline serum levels of hypophyseal hormones and prolactin in male patients and in the control. One or both types of steroid hormone receptors, the content of androgen receptors being higher than that of estrogen receptors, varying in a wide range were detected in 71% of the patients with malignant neoplasms. The occurrence of steroid hormone receptors was higher in adenocarcinomas, while their content was significantly higher in normal pancreatic tissues. The occurrence of androgen receptors was higher in male patients at the early stages of the disease, predominantly in highly differentiated adenocarcinomas located in the body of the pancreas. The content of androgen receptors was higher in male patients, in metastasizing tumors, in adenocarcinomas located in the body of the pancreas, and in patients without clinical and laboratory evidence of the mechanical jaundice syndrome. The content of androgen receptors positively correlated with the maximum size of the tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02446919
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Charactersitics of gastroprotein synthesis and phosphorylation in human gastric carcinoma cells (1996)
    Springer
    Bulletin of experimental biology and medicine 121 (1996), S. 610-614 
    Details
    ISSN: 1573-8221
    Keywords: gastric carcinoma ; mucous cells ; gastroproteins ; Mg-dependent phosphorylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Characteristics of the synthesis and Mg-dependent phosphorylation of gastroproteins are studied in intact cells of the mucous coat of the stomach and in the cells of tumor nodes in the same patients. Comparison of polypeptide maps reveals 4 main types of mucous coats which contain p18 (phosphorylated or not), p20, or p22, or no characteristic feature at all. Two kinds of changes, namely, accessory proteins and proteins disappearing from the spectrum, are manifested mainly in extracts of primary tumors as compared to homologous mucous coats of the stomach. Three classes of gastric tumors are distinguished according to the difference between tumor and normal cell polypeptides: I) no difference, II) isolated differences, and III) numerous qualitative and quantitative differences in gastropolypepides and their phosphoforms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02447132
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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