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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Schizophrenia Research 9 (1993), S. 216 
    ISSN: 0920-9964
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1463
    Keywords: [3H]paroxetine ; hippocampus ; schizophrenia ; neuroleptic drugs ; suicide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary [3H]paroxetine binding to membrane from hippocampus, obtained at autopsy, from 24 schizophrenic and 24 non-schizophrenic subjects has been measured. The affinity of [3H]paroxetine binding to hippocampal membrane was decreased in subjects with schizophrenia (Kd=0.50 ± 0.04 vs. 0.24 ± 0.02nM; mean ± S.E.M. p 〈 0.001) but was not different in schizophrenic subjects who had or had not committed suicide (Kd=0.50 ± 0.07 vs. 0.50 ± 0.04nM). The density of [3H]paroxetine binding sites did not differ between the schizophrenic and non-schizophrenic subjects. For the schizophrenic subjects, there was no relationship between ante-mortem neuroleptic drug treatment and [3H]paroxetine binding to the hippocampal membrane. Finally, this study has shown that neuroleptic drug treatment of rats does not alter [3H]paroxetine binding to the hippocampal membranes. Thus, it would seem that the changes in the affinity of [3H]paroxetine binding to the hippocampus of schizophrenic subjects are not likely to be due to neuroleptic drug treatment but may be involved in the pathology of the illness.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 104 (1997), S. 1371-1381 
    ISSN: 1435-1463
    Keywords: Schizophrenia ; protein kinase C ; adenylate cyclase ; hippocampus ; frontal cortex ; human brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Changes in G-protein linked neurotransmitter receptors have been reported in a number of regions of the brain of schizophrenic subjects. These changes, if functional, could cause a change in proteins such as protein kinase C (PKC) and adenylate cyclase (AC) which are important components of the G-protein linked second messenger cascades. We therefore used autoradiography to measure the distribution and density of [3H]phorbol ester binding to PKC and [3H]forskolin binding to AC in tissue obtained at autopsy from schizophrenic and non-schizophrenic subjects (Controls). There were significant decreases in the density of PKC in the parahippocampal gyrus (687 ± 60 vs. 885 ± 51fmol/mg TE; mean ± SEM; p 〈 0.01) and in AC in the dentate gyrus (75 ± 4.9 vs. 92 ± 6.5, p 〈 0.05) from the schizophrenic subjects. These data could indicate that changes in neurotransmitter receptors in the hippocampus from subjects with schizophrenia could have resulted in a change in their associated second messenger systems.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Annales geophysicae 15 (1997), S. 101-112 
    ISSN: 0992-7689
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The aim of this paper is to test the effectiveness of feature models in ocean acoustic forecasting. Feature models are simple mathematical representations of the horizontal and vertical structures of ocean features (such as fronts and eddies), and have been used primarily for assimilating new observations into forecasts and for compressing data. In this paper we describe the results of experiments in which the models have been tested in acoustic terms in eddy and frontal environments in the Iceland Faeroes region. Propagation-loss values were obtained with a 2D parabolic-equation (PE) model, for the observed fields, and compared to PE results from the corresponding feature models and horizontally uniform (range-independent) fields. The feature models were found to represent the smoothed observed propagation-loss field to within an rms error of 5 dB for the eddy and 7 dB for the front, compared to 10–15-dB rms errors obtained with the range-independent field. Some of the errors in the feature-model propagation loss were found to be due to high-amplitude ‘oceanographic noise’ in the field. The main conclusion is that the feature models represent the main acoustic properties of the ocean but do not show the significant effects of small-scale internal waves and fine-structure. It is recommended that feature models be used in conjunction with stochastic models of the internal waves, to represent the complete environmental variability.
    Type of Medium: Electronic Resource
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