ISSN:
1573-0778
Keywords:
Imidazobenzothiazole derivatives
;
leukemic cells
;
cell growth
;
cell cycle kinetics
;
DNA binding
;
DNA and RNA synthesis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Abstract New derivatives of imidazothiazole and imidazobenzothiazole were testedin vitro for their potential antiproliferative activity. Four imidazobenzothiazole derivatives exhibited a cytotoxic activity against two leukemic cell lines, compound I being the most effective. Cell cycle kinetics studies showed that this drug delays the progression of cells from G1 to S and G2 M phases. An inhibitory effect on DNA and RNA synthesis was also observed. The antiproliferative effect of this compound, analogue of immunosuppressive agents, suggested that it could be of interest for a therapeutic use and for the synthesis of new derivatives.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00624761
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