ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The intrinsic viscosity and molecular weight of several samples of polyhydroxyethylaspartamide with differing degrees of polymerization were determined and related, according to the Mark-Howink equation. The a exponent is consistent with a random-coil structure. The average unperturbed dimensions of the polymer, the dimensions in water, and the water-polymer interaction parameter were calculated according to Flory and Fox. The interaction of the polymer with water may explain its good efficacy as a plasma expander, as has previously been demonstrated in biological experiments. The behavior of the molecule in 6 M guanidine hydrochloride solution was also studied: this solvent has a very slight effect on the configuration of the polymer, in contrast with its normal effect on proteins.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.1974.360130904
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