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  • 1
    Electronic Resource
    Electronic Resource
    Mycobacterial Heat-Shock Protein 65 Induces Proinflammatory Cytokines but does not Activate Human Mononuclear Phagocytes (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 39 (1994), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The 65 kDa heat-shock protein (Hsp65), a well-conserved and immunodominant antigen which elicits a cellular and humoral immune response, may play a role in host defence against invading microorganisms and autoimmune disorders. The aim of the present study was to assess the effects of Hsp65 on the functional activities of human mononuclear phagocytes in the absence of lymphocytes. Incubation with Hsp65 resulted in an enhanced release of TNF-γ and IL-1γ by human monocytes and monocytederived macrophages (MDM). The amount of cytokines released by these cells in response to Hsp65 was similar to that released in response to IFN-γ together with LPS. Incubation with ovalbumin did not stimulate the release of these cytokines. In vitro stimulation of monocytes with Hsp65 enhanced the membrane expression of complement receptor III but did not influence either the expression of Fc-receptor I and HLA class-II antigens or the release of reactive oxygen intermediates. Therefore, Hsp65 stimulated monocytes cannot be considered to be activated according to classical criteria. The release of the proinflammatory cytokines TNF-γ and IL-1γ by human mononuclear phagocytes in response to Hsp65 indicates that this protein can contribute to both host defence and tissue damage in inflammatory lesions characterized by an abundant expression of Hsp65.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1994.tb03421.x
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  • 2
    Electronic Resource
    Electronic Resource
    Saccharomyces fungemia complicating Saccharomyces boulardii treatment in a non-immunocompromised host (2000)
    Springer
    Intensive care medicine 26 (2000), S. 825-825 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340051261
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Recurrent Listeria monocytogenes bacteraemia in a liver transplant patient (1990)
    Springer
    Infection 18 (1990), S. 107-108 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir berichten über eine rezidivierendeListeria monocytogenes-Bakteriämie bei einer 46 Jahre alten Lebertransplantat-Empfängerin. Durch Serotypisierung wurde festgestellt, daß die beiden Bakteriämien durch verschiedene Stämme ausgelöst wurden. Die Möglichkeit einer wiederaufflackernden persistierenden Infektion wurde ausgeschlossen. Wir gehen davon aus, daß die rezidivierende Bakteriämie bei dieser prädisponierten Patientin durch Reinfektion verursacht wurde und daß die Antibiotikatherapie (Ampicillin plus Aminoglykosid) den Infektionserreger vollständig eliminiert hatte. Es bestand folglich keine Indikation für eine Antibiotika-Langzeit-Suppressionstherapie. Die Infektionsquelle für dieseL.-monocytogenes-Infektionen wurde nicht gefunden.
    Notes: Summary We report a case of a recurrentListeria monocytogenes bacteraemia in a 46 year-old liver transplant patient. Serotyping revealed that the two episodes of bacteraemia were caused by different strains. The possibility of a recrudescence of a persisting infection was rejected. We concluded that the recurrent bacteraemia in this predisposed patient was due to re-infection, and that antibiotic treatment (amoxicillin plus an aminoglycoside) resulted in a complete eradication of the infective microorganism. Therefore long-term suppressive antibiotic treatment was not indicated. The source of theseL. monocytogenes infections was not found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01641427
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  • 4
    Electronic Resource
    Electronic Resource
    Bioprosthetic valve endocarditis caused byNeisseria elongata subspeciesnitroreducens (1996)
    Springer
    Infection 24 (1996), S. 258-260 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir berichten über einen neuen Fall von Bakteriämie und Endokarditis durchNeisseria elongata ssp.nitroreducens bei einer 74-jährigen Frau, die 1992 einen Aortenklappenersatz durchgemacht hatte.N. elongata ssp.nitroreducens unterscheidet sich von anderen Subspecies vonN. elongata durch zusätzliche Nitratreduktion ohne Gasbildung. Wie die meistenNeisseria spp. — mit Ausnahme vonNeisseria meningitidis undNeisseria gonorrhoeae — wird dieseN. elongata ssp.nitroreducens in der Regel als “apathogene”Neisseria sp. eingeordnet. Unser Fallbericht zeigt, daß die Anwesenheit einer Subspecies dieser Gruppe dann von klinischer Bedeutung ist, wenn die Isolation aus einer normalerweise sterilen Umgebung erfolgt ist. Bei empfänglichen Personen kann dieser Keim schwere Krankheitssymptome verursachen.
    Notes: Summary A new case ofNeisseria elongata ssp.nitroreducens bacteremia and endocarditis in a 74-year-old woman who had undergone aortic valve replacement in 1992 is reported in detail.N. elongata ssp.nitroreducens differs from the other subspecies ofN. elongata in the additional reduction of nitrate without gas formation. Like mostNeisseria spp. exceptNeisseria meningitidis andNeisseria gonorrhoeae, thisN. elongata ssp.nitroreducens is usually classified in the group of “non-pathogenic”Neisseria spp. This case report indicates that the presence of subspecies of this group is significant when isolated from normally sterile sites and can cause severe disease in susceptible individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01781107
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  • 5
    Electronic Resource
    Electronic Resource
    Isolation of vancomycin-resistant enterococci in haematologic patients (1991)
    Springer
    European journal of clinical microbiology & infectious diseases 10 (1991), S. 32-34 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract After the occurrence of septicaemia with a vancomycin-resistantEnterococcus faecalis strain in a patient, it was decided to determine the number of carriers of vancomycin-resistant cocci among haematologic patients. During a period of six months 135 stool samples from 25 children, and 400 samples from 70 adults were studied. All samples from the children were negative for vancomycin-resistant cocci. Nine of the adult patients had cultures positive for cocci, all identified as enterococci, which were highly resistant to vancomycin (MIC〉250µg/ml), sensitive to amoxicillin, moderately resistant to gentamicin, slightly resistant to teicoplanin, and sensitive to daptomycin. None of these patients had been given vancomycin prior to the isolation of the vancomycin-resistant enterococci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967094
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  • 6
    Electronic Resource
    Electronic Resource
    Increase in Penicillin Resistance Rates in Belgium due to Clonal Spread of a Penicillin-Resistant 23F Streptococcus pneumoniae Strain (1999)
    Springer
    European journal of clinical microbiology & infectious diseases 18 (1999), S. 120-125 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In 1994 a sudden increase in penicillin resistance was observed in Belgium among invasive pneumococci. To determine whether this increase was due to clonal spread of a resistant strain or to de novo acquisition of penicillin resistance, pneumococci of capsular types 23F, 19, 14, 9, and 6, isolated in 1993 and 1994, were analyzed by capsular serotyping and DNA macrorestriction analysis, resolved by pulsed-field gel electrophoresis. Furthermore, pneumococcal isolates from northern France, a region with a high prevalence of penicillin resistance, and from southern Belgium, a region with a low but increasing prevalence of penicillin resistance, were analyzed. The rate of resistance of invasive pneumococci to penicillin increased from 2.3% in 1993 to 7.6% in 1994. Pneumococcal serotype 23F represented 26.7% of the penicillin-resistant isolates in 1993 and 40.4% in 1994, while the prevalence of serotype 23F decreased from 10.9% in 1993 to 8.8% in 1994. In 1994 up to 35.8% of serotype 23F isolates were penicillin resistant. The Belgian penicillin-resistant 23F isolates from 1994 were genetically closely related to the French 23F penicillin-resistant isolates and, as clones were clearly distinct from the other serotypes as well as from the penicillin-susceptible 23F isolates. These data demonstrate the important contribution of the clonal spread of a penicillin-resistant pneumococcal strain in the overall increase of penicillin resistance in our country.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100960050239
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  • 7
    Electronic Resource
    Electronic Resource
    Ankylosing spondylitis. An unusual manifestation of familial Mediterranean fever. Report of a case complicated by amyloidosis and polyneuropathy (1989)
    Springer
    Clinical rheumatology 8 (1989), S. 408-412 
    Details
    ISSN: 1434-9949
    Keywords: Familial Mediterranean Fever ; Ankylosing Spondylitis ; Amyloidosis ; Polyneuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report a case of familial Mediterranean fever (FMF) with typical clinical and roentgenological findings of ankylosing spondylitis. The spinal involvement in FMF is discussed. A second unusual feature of this case is the occurrence of polyneuropathy which could possibly be ascribed to the slowly evolving amyloidosis during continuous colchicine treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030357
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