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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 7 (1964), S. 677-678 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 6 (1967), S. 88-92 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Aquaculture research 30 (1999), S. 0 
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The spotted wolffish Anarhichas minor (Olafsen), with its rich and tasty fillets, popular skin and high growth rates in captivity, is a promising candidate for cold-water aquaculture. We have established a production line for the wolffish during 5 years of active research on the biology of the species. Our broodstock, sampled from the Barents Sea, has mainly spawned during autumn. The females must be stripped as soon as possible after ovulation. The best egg batches have shown c. 100% fertilization and survival rates between 60% and 80% during the 800- to 960-daydegrees-long incubation period. Rearing temperatures of 6 °C, 8 °C, ambient and decreasing temperatures have turned out to be satisfactory for survival. Treatment with 150 p.p.m. glutardialdehyde twice a month is recommended to control microorganism growth on eggs. Premature hatching has been a problem in individual egg batches; the reasons are not fully understood. Normally hatched individuals are ≈ 22 mm long and well developed, with a small yolk sac, which is completely resorbed after about 4 weeks at 6–8 °C. The fry have been successfully start fed on formulated feed as well as Artemia. Highest early growth rates have been noted at 8 °C, but overall survival was best at 6 °C. On-growth of spotted wolffish juveniles fed formulated dry floating feed at low temperatures in shallow raceways has been promising. After 2, 3 and 4 years, the mean weights of the first generation produced in aquaculture were 0.7, 2.7 and 5.1 kg respectively. These individuals now make up the broodstock at a recently established commercial production facility.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Aquaculture research 32 (2001), S. 0 
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Temperature influenced the developmental rate, survival and early growth of eggs and embryos of spotted wolffish, Anarhichas minor (Olafsen), an interesting candidate for cold water cultivation. The total incubation period decreased from 220 days at 4 °C (880 daydegrees), to 177 days at 6 °C (1062 daydegrees) and 150 days at 8 °C (1200 daydegrees) in these experiments. The proportion of normal embryos and survival of eggs until hatching were highest when the eggs were incubated at 6 °C. During the incubation period, the embryo and yolk sac size at 280 daydegrees was not significantly different but at 850 daydegrees the embryo size was inversely related to temperature and the remaining yolk sac size positively correlated with the incubation temperature. The transformation of yolk to body mass during incubation appeared to be most efficient at 4 °C, and the embryos hatched with a larger visible yolk sac at 6 and 8 °C. The largest larvae (wet-weight) hatched from the largest eggs and the egg groups incubated at the lowest temperature (4 °C). There was no effect of temperature on meristic characters. During 6 weeks post-hatching, all larvae from the three temperature groups were fed formulated dry feed in excess at 8 °C in low water-level raceway systems. During startfeeding, the larvae from eggs incubated at the lowest temperature (4 °C) showed the highest growth rates (SGR). Best survival of larvae was noted among batches incubated at 6 °C.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 59 (2001), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Wolffish Anarhichas lupus (Anarhichadidae) hatch from large demersal eggs (c. 5–6 mm) after a long incubation period (c. 800–1000 degree days) at 20–25 mm LT with a juvenile appearance: a small yolk sac, pigmented but partly transparent skin densely supplied with mucous cells, well developed body musculature and a cartilaginous skeleton. The results of histomorphological studies illustrate the apparent functionality of tissues and organs at hatching. The mucosa of the oral cavity and various parts of the digestive channel are well differentiated and the cellular characteristics are described within each region. A stomach with gastric glands is established before hatching. The pancreas has well developed endo- and exocrine tissue and the hepatocytes are vacuolized. The kidney tissue has numerous tubuli and haematopoietic tissue in the bilobed head region. The spleen, thymus and thyroid glands also appear mature. Cones are dominant in the visual cell layer of the retina.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 41 (1992), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Metamorphosis in cod, Gadus morhua L., was investigated with respect to morphological changes in the alimentary tract (mouth, stomach and pyloric caeca) and external characters (finfold and fin development). Morphometric measurements and histological investigations were made on both larvae and juveniles and all fish lengths are given as standard length. Median unpaired fins started to develop when the fish were 9–10 mm in length. The larval median finfold was resorbed when fish reached a size of 11–15 mm. The vertebrae were formed in fish of 11–20 mm. The supraterminal mouth, seen in larvae 〈12 mm, changed gradually to a sub-terminal position in juveniles larger than 65 mm. The development of the stomach and pyloric caeca started at 15 mm and the juvenile form was seen in fish of 40 mm. The ability to store and grind food particles in the stomach developed gradually as fish increased in size from 20 to 40 mm. Compared to many other teleost species, cod juveniles are relatively large when the stomach and pyloric caeca become fully developed. These findings may have important implications for both start-feeding of cod larvae and the weaning of juveniles on to artificial diets.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Analytical Biochemistry 218 (1994), S. 478-479 
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0011-2240
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Histopathology 43 (2003), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  To investigate the prognostic significance of chromosomal alterations in colorectal cancer patients. Histopathological tumour classification is still considered to be the gold standard for the characterization of solid tumours. However, it is well known that such established parameters do not satisfactorily predict the clinical outcome in individual cases. Markers that reliably predict survival are needed. These markers should guide the clinical treatment of neoplastic disease.Methods and results:  Chromosomal imbalances in 61 colorectal carcinoma specimens in 37 patients determined by comparative genomic hybridization were correlated with patient survival using custom-made computer software which enabled the assessment of individual chromosomal loci. Kaplan–Meier analysis revealed that over-representations of 2p14-15, 6q23-6q24, 15q22-15q23, 22q11.2 and deletions of 1p36.1-36.2, 4q31.3, 4q35, 8q12-q21, 8p11.2 and 9p22 were significantly associated with shorter disease-specific survival, whereas over-expression of 20q13.3 and deletion of 18q11.2 were significantly associated with longer disease-specific survival in this collection of colorectal cancers. Multivariate Cox proportional hazards regression models consistently identified gains of 2p14-15, 15q22-23, 22q11.2 and losses of 1p36.1-36.2 and 4q35 as independent markers of shorter patient survival carrying greater significance than the classical clinicopathological parameters of nodal status and tumour grade.Conclusions:  These five markers allow a molecular categorization of patients into high and low clinical risk groups. Thus, the genomic data have refined the histopathological classification highlighting the necessity for a supplementary genetically based stratification of colorectal cancer.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    International Journal of Biochemistry 8 (1977), S. 395-401 
    ISSN: 0020-711X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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