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  • 1
    Electronic Resource
    Electronic Resource
    Scanning and transmission electron microscopy of Ewing's sarcoma of bone (typical and atypical variants) (1983)
    Springer
    Virchows Archiv 398 (1983), S. 329-346 
    Details
    ISSN: 1432-2307
    Keywords: Ewing's sarcoma ; Transmission electron microscopy (TEM) ; Scanning electron microscopy (SEM)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Scanning electron microscopy (SEM) is of value for the differential diagnosis of Ewing's tumor of bone. Based upon 9 new cases which were observed with SEM and TEM (transmission electron microscopy), this paper puts into consideration, for the first time, the SEM ultrastructure of Ewing's sarcoma (both variants; typical Ewing's sarcoma and the large cell Ewing's sarcoma). Furthermore, a new case of vascular Ewing's sarcoma, studied with TEM, is discussed and included in the differential diagnosis with other round cell sarcomas of bone. Both Ewing's sarcoma types evidence common ultrastructural characteristics, but the atypical variant (large cell type) shows a greater variation in cell size and contour. The cell surfaces displayed smooth structures, interrupted only by clusters of short, stub-like microvilli. Isolated cilia were also observed. Variations in cell contour and size within the same tumour are also induced through intensive chemotherapy, as noted in one of our cases. SEM seems to be suitable for the differentiation of Ewing's tumours from other primary malignancies of the bone marrow, as is the case of the so-called “reticulum cell sarcoma of bone” or malignant non-Hodgkin lymphoma. SEM studies associated with TEM give further support to the mesenchymal origin of this neoplasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00583589
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  • 2
    Electronic Resource
    Electronic Resource
    Bipolar (neural and myoblastic) phenotype in cell lines derived from human germ cell tumours of testis (1997)
    Springer
    Virchows Archiv 430 (1997), S. 291-300 
    Details
    ISSN: 1432-2307
    Keywords: Human germ cell tumour of testis ; Cell culture ; Neural differentiation ; Myoblastic differentiation ; Cytogenetic analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Non-seminomatous germ cell tumours of the testis (NSGCT) form a heterogeneous group of neoplasms. Cell lines derived from NSGCT may provide useful data concerning the biology of neoplasic precursor germ cells, differentiation of tumour stem cells and the relationship between various tissue components of these tumours. Four NSGCT were studied, two mixed tumours composed of teratocarcinoma, yolk sac and trophoblastic elements, and two malignant teratomas with a massive neuroectodermal component, equivalent to primary neuroectodermal tumours (PNET) of the testis. The explanted tumours gave rise to various cell populations, including epitheloid cells, flattened large cells, spindle cells and tear drop cells of neuroblastic type. Ultrastructurally, cultured cells expressed various degrees of neural and muscular differentiation: neurosecretory granules, intermediate filaments of glial nature, and filaments resembling Z-bands. Cultured cells showed the expression of several neural and muscular markers, including neurofilaments, cytokeratin, actin, desmin, neuron-specific enolase, glial fibrillary acidic protein and HNK-1. In addition, three cases expressed HBA-71 antigen and two expressed MyoDI protein. All cases were aneuploid, and an isochromosome 12p, i(12p), was detected in three cases. Myoblastic and neural cells are the predominant tumour cells that grow in vitro, independent of the nature and composition of the primary germ cell tumour. A histogenetic relationship between germ cell tumours and small round cell tumours of childhood is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01092752
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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