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High-dose carmustine for high-grade gliomas in childhood (1997)

Bouffet, Eric ; Khelfaoui, Fatima ; Philip, Irène ; [et al.]

Springer

Cancer chemotherapy and pharmacology 39 (1997), S. 376-379

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ISSN: 1432-0843

Keywords: Key words BCNU ; Autologous bone marrow transplantation ; Child ; High-grade glioma.

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Carmustine (BCNU) has proved to be of value against a variety of primary brain tumors. This agent exhibits a steep dose-response curve in in vitro and animal tumor models and has been proposed for use in high-dose chemotherapy as a single agent or in combination. We conducted a phase II study to assess high-dose BCNU in children with high-grade gliomas. A total of 13 children with high-grade gliomas were treated in a phase II study using high-dose BCNU (800 mg/m2) followed by autologous bone marrow transplantation. Eight patients were newly diagnosed, and five were treated at the time of tumor recurrence. Seven patients had diffuse intrinsic brain-stem gliomas. The response was assessed at 1 month after treatment. Only one objective effect was observed. Five patients had stable disease and seven progressed. The immediate toxicity was mild; however, one patient developed fatal respiratory distress at 50 days after treatment with high-dose BCNU. Dose escalation of BCNU does not seem beneficial in children with high-grade gliomas.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002800050586

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Phenotypic characterization of Ewing sarcoma cell lines with monoclonal antibodies (1986)

Lipinski, Marc ; Braham, Karim ; Philip, Irène ; [et al.]

New York, N.Y. : Wiley-Blackwell

Journal of Cellular Biochemistry 31 (1986), S. 289-296

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ISSN: 0730-2312

Keywords: histogenesis ; antigenic phenotype ; flow cytometry ; N-CAM ; HNK-1 monoclonal antibody ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: The histogenesis of Ewing sarcoma, the second most frequent bone tumor in humans, remains controversial. Four Ewing cell lines were analyzed by immunological methods. A panel of antibodies directed to T, B, and myelomonocytic markers gave negative results. Surface antigens recognized on Ewing cells were found to be related to the neuroectoderm lineage. Ganglioside GD2, a marker of neuroectodermal tissues and tumors, was present on all lines. These were also stained by the mouse monoclonal antibody HNK-1, which detects a carbohydrate epitope present on several glycoconjugates of the nervous system, including two glycoproteins, the myelin-associated glycoprotein and the neural cell-adhesion molecule (N-CAM), and an acidic glycolipid of the peripheral nervous system. The P61 monoclonal antibody, which reacts with a peptide moiety of N-CAM, and a rabbit antiserum, raised to purified mouse N-CAM and not recognizing the HNK-1-defined epitope, were also reactive. By contrast, all antibodies specific for hematopoietic cell surface antigens were totally negative. Besides these antigenic features, Ewing sarcoma cells are characterized by a specific t(11:22)(q24;q12) translocation also observed in neuroepithelioma, a neuroectodermal tumor, suggesting a possible evolutionary related origin. The recent finding that the human N-CAM gene is located at the vicinity of the breakpoint on chromosome 11 indicates that it might be involved in genetic rearrangements occurring in this region.

Additional Material: 3 Ill.