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  • 1
    Electronic Resource
    Electronic Resource
    Podocarpus gracilior and Callitris verrucosa—newly identified allergens that crossreact with Cupressus sempervirens (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 25 (1995), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thirty-six symptomatic patients, with positive skin reactions to Cupressus sempervirens pollen extract were skin-tested with pollen extracts of Podocarpus gracilior and Callitris verrucosa, of these 17 (47%) had positive responses to P. gracilior, nine (25%) to C. verrucosa, and six (17%) to both. None of the non-atopic healthy controls had positive reactions to either of the extracts. Radioallergosorbent test (RAST)-inhibition studies were performed with pooled sera from three patients. Fifty per cent inhibition was obtained with 11 μg protein of C. sempervirens, 54μg of P. gracilior, and 71 μg of C. verrucosa; however, when pollen extract of Olea europaea, an unrelated allergen, was tested, 265μg protein were needed to obtain 50% inhibition. One-dimension sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis of pollen extracts from the three species revealed that they had several very similar protein bands. Using Western blot analysis, several closely related IgE binding proteins were identified in the three species. It was concluded that the pollen grains of P. gracilior and of C. verrucosa are potentially allergenic. The presence of common allergenic proteins indicate partial crossreactivity with C. sempervirens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1995.tb01077.x
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  • 2
    Electronic Resource
    Electronic Resource
    Olive pollen induces asthmatic response (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 21 (1991), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We provide evidence that olive pollen extract can induce asthmatic response. The pattern of airway response to olive pollen is investigated. Nineteen patients with seasonal allergic rhinitis and asthma, suspected to be due to olive pollen, all of whom had positive skin-prick test, were investigated. Bronchial challenge with olive pollen extract were performed and the peak flow rate was followed for 20 hr. Eight patients developed dual asthmatic response (DAR), six patients developed early asthmatic response (EAR) and five patients had no asthmatic response. The early maximal fall in FEVI and the PD15 were not different between the group with DAR and the group with EAR only. We conclude that olive pollen can induce dual asthmatic response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1991.tb01664.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Immediate adverse reactions to immunotherapy in allergy (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 47 (1992), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report our experience of adverse reactions to immunotherapy (IT) in patients with insect venom allergy and inhalant respiratory allergy. Adverse reactions included large local reactions, generalized cutaneous reactions or systemic reactions. Among 87 patients treated for venom allergy, 43% had adverse reactions during the course of IT, averaging 2.5 reactions per patient and per course of IT. Nine had systemic reactions, of which 7 required adrenaline administration. Among 52 patients treated with inhalant allergen extracts, 40% had adverse reactions averaging 3 reactions per patient per course of treatment. Ten patients had systemic reactions but only 2 required adrenaline administration. There was no difference between the rate of adverse reactions in the venom and the inhalant treatment groups. IT has an inherent risk which has to be weighed against its benefits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1992.tb00660.x
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  • 4
    Electronic Resource
    Electronic Resource
    Immunologic Studies in Darier's Disease (1988)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 27 (1988), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: : Humoral and cellular immunity were evaluated in 10 patients with Darier's disease. The mean levels of serum immunoglobulins, serum complement, peripheral macro-phages, and peripheral B and T lymphocytes were within normal limits. Secretory IgA was present in all patients studied. Skin tests for delayed hypersensitivity revealed complete anergy in one of the eight patients tested. Lymphocyte transformation tests revealed statistically significant enhanced responsiveness to both PHA and ConA mitogens in several concentrations studied. These findings may suggest either the existence of alterations in immunoregulation of lymphocyte subpopulations in Darier's disease or may be limited to alterations in membrane functions of certain lymphocyte subpopulations which can be detected only in vitro. The role that such immunologic aberrations may play in the pathogenesis of Darier's disease is still obscure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1988.tb01281.x
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  • 5
    Electronic Resource
    Electronic Resource
    Monoclonal immunoglobulins in patients with carcinoma of the colon (1980)
    Springer
    Cancer immunology immunotherapy 9 (1980), S. 81-86 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Structural studies were performed on five monoclonal immunoglobulins isolated from patients with carcinoma of the colon. Serologic analysis revealed that two of the five proteins shared idiotypic antigenic determinants; these two but none of the three others had VHIII heavy chains. The results demonstrated a close structural similarity between the heavy chains of these two proteins both in their antigen-binding sites (the hypervariable region) and in their framework regions. Determination of the NH2-terminal amino acid sequences indicated that the light chain variable regions of all five proteins were either VxII or VxIII. These data suggest that monoclonal immunoglobulins in patients with carcinoma of the colon have restricted heterogeneity and that, in some cases the production of monoclonal immunoglobulin(s) and the development of a solid tumor in a given patient may be related events.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199533
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  • 6
    Electronic Resource
    Electronic Resource
    The significance of C3 and C4 complement levels in lupus nephritis (1974)
    Springer
    International urology and nephrology 6 (1974), S. 233-238 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract C3 and C4 serum complement component levels were examined during various stages of disease activity in 14 SLE patients. It was found that C3 levels were more sensitive index of disease activity than those of C4. C3 levels lower than C4 as expressed by a C3/C4〈0.5 were found in 25% of the examined disease episodes; they were only observed in patients with renal involvement during or next to periods of disease activity. We suggest that such a pattern of C3 and C4 when found during the follow-up of SLE patients indicates active renal disease, and implies the recruitment of the alternate pathway for the activation of the complement system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02089270
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  • 7
    Electronic Resource
    Electronic Resource
    The detection of a common idiotype of anti-DNA antibodies in the sera of patients with monoclonal gammopathies (1986)
    Springer
    Journal of clinical immunology 6 (1986), S. 194-204 
    Details
    ISSN: 1573-2592
    Keywords: Monoclonal gammopathies ; monoclonal antibodies ; autoantibodies ; autoimmune diseases ; anti-DNA antibodies ; multiple myeloma ; macroglobulinemia ; idiotypes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The sera of 265 patients with monoclonal gammopathies were examined for the presence of a dominant idiotype of the anti-DNA antibody [16/6 idiotype (Id)] and for anti-DNA activity. An enzyme-linked immunosorbent assay (ELISA) with a rabbit anti-16/6 antibody revealed 23 (8.7%) sera that contained increased concentrations of the idiotype. Seven of the patients had benign monoclonal gammopathy, three multiple myeloma, three Waldenström macroglobulinemia, five essential mixed cryoglobulinemia, and five monoclonal cryoglobulinema. In 5 of the 23 sera, antinuclear activity was also noted. In 11 of the 16/6 Id-positive sera the anti-nucleic acid antibody reactions were found to be polyspecific, reacting with polydeoxythymidilic acid and polyinosinic acid, in addition to single-stranded DNA and double-stranded DNA. Similar results were achieved with the purified serum monoclonal components. The specificity of the idiotype analysis was demonstrated with an unrelated dominant idiotype of anti-HBsAg antibody. In none of the patients, except one (with essential mixed cryoglobulinemia), was lupus symptomatology noted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00918699
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