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  • 1
    Electronic Resource
    Electronic Resource
    Decreased bone marrow iron in chronic granulocytic leukaemia: A consistent finding not reflecting iron deficiency (1986)
    Springer
    Annals of hematology 53 (1986), S. 305-308 
    Details
    ISSN: 1432-0584
    Keywords: Chronic granulocytic leukaemia ; Bone marrow iron ; Serum ferritin ; Isotopic studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The iron status of 50 patients with Ph'-positive chronic granulocytic leukaemia (CGL) was evaluated at diagnosis by means of bone marrow and blood studies. A decreased or absent iron in semiquantitative estimation on bone marrow smears was observed in 92% of patients, and 88% had a low sideroblast score. In contrast, normal Hb and serum iron concentrations were found in the majority of cases, and only two out of the 50 patients displayed a decreased serum ferritin. To ascertain whether the bone marrow pattern of iron depletion could be due to an expansion of the red cell mass, the latter parameter was measured by isotopic methods in a subgroup of 11 patients. Normal or slightly increased values were obtained in all cases. We conclude that absent or decreased marrow iron is a common feature in the chronic phase of CGL, that generally does not reflect true iron deficiency. Since such a finding is also usual in polycythaemia vera and idiopathic myelofibrosis, it should be included among the features shared by the chronic myeloproliferative disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320889
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  • 2
    Electronic Resource
    Electronic Resource
    Iron stores in essential thrombocythaemia (1989)
    Springer
    Annals of hematology 58 (1989), S. 291-294 
    Details
    ISSN: 1432-0584
    Keywords: Essential thrombocythaemia ; Iron stores ; Serum ferritin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The iron status of 26 patients with essential thrombocythaemia (ET) was evaluated at diagnosis by means of bone marrow iron and blood studies, including serum ferritin determination. Nine patients were males, 17 females, and the mean age was 53 years (range 7–81). A decreased or absent iron level by semiquantitative estimation on bone marrow smears was observed in 77% of patients, and 81% had a low sideroblast score. Such a marrow pattern of iron depletion was equally distributed between both sexes. Contrasting with this, normal Hb, MCV, serum iron and serum ferritin were registered in the majority of cases. According to these results, absent or decreased marrow iron would be a common feature in ET, generally not reflecting true iron deficiency, as it occurs in the remaining chronic myeloproliferative disorders. Thus, in patients in whom ET is suspected, the diagnostic criterion of ruling out iron deficiency would be better served by serum ferritin measurement than by bone marrow iron estimation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320169
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Migration pathways of hypodermically injected technetium-99 m in dogs (2000)
    Springer
    European radiology 10 (2000), S. 1019-1025 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Technetium-99 m – Hypodermic injection – Radioactive tracer migration – Linear pathways – Adult male beagles – Capillary Electrophoresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Hypodermic injection of technetium-99 m (99 mTC-pertechnetate) at points of low electrical resistance give rise to rapid, longitudinal, and progressive diffusion of the radioactive tracer. We assessed the effect of cutaneous incisions that did not intersect the migration trajectory of 99 mTc-pertechnetate and the re-establishment of pathways after the suture of incisions that intersected the migration trajectory. Linear and rapid migration of 99 mTc-pertechnetate was not altered or prevented by incisions that did not intersect the migration pathway. Different patterns of 99 mTc-pertechnetate spread were found when incisions intersected the radioactive pathways until restoration of the normal migration pathway observed in undamaged skin occurred. In all experiments in which migration of 99 mTc-pertechnetate was observed, lavage of surgical wounds was followed by disappearance of the 99 mTc-pertechnetate migration observed around the suture. Linear migration of the tracer was not observed when the incision was left uncovered, filled with petroleum jelly, or with a solid silicone sheet, but it was seen when non-sutured incisions were filled with transonic or silicone gel or covered with a solid silicone sheet parallel to the cutaneous plane. These data show that after a cutaneous incision that intersected the diffusion trajectory of the radioactive tracer, linear migration of 99 mTc-pertechnetate hypodermically injected at points of low electrical resistance was restored before healing of the cutaneous incision and was independent of incisions made on the skin not overlying the radioactive pathway. A mechanism similar to that of capillary electrophoresis is suggested to explain the hypodermic diffusion of inert particles through specific and constant linear pathways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300051056
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    Paper (German National Licenses)
    Fulltext
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